Tbio TMEM8B Transmembrane protein 8B

Protein Summary

Description

May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion.

Uniprot Accession IDs

• A6NDV4
• B3KQF3
• O75539
• Q49AB1
• Q4KMX5
• Q5TCW5
• Q9HBY2
• Q9P0U7

Gene Name

• TMEM8B

Ensembl ID

• ENST00000377988
• ENSP00000367227
• ENSG00000137103
• ENST00000377991
• ENSP00000367230
• ENST00000377996
• ENSP00000367235
• ENST00000439587
• ENSP00000395810
• ENST00000650015
• ENSP00000497766

Symbol

• C9orf127
• NGX6
• NAG5
• NGX6
• NAG-5
• C9orf127

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.8
histone modification site profile	0.77
virus perturbation	0.72
tissue sample	0.66
transcription factor	0.54

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Transmembrane Protein 8b

DTO Classes

Protein / Cell Adhesion / Transmembrane Protein 8b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.6   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.6   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0