| Tdark | Transmembrane protein 87B |
May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN).
This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. [provided by RefSeq, Aug 2016]
This gene encodes a protein that may interact with human papillomavirus type 18 E6 oncogene. The protein is also likely to be involved in endosome-to-trans-Golgi network retrograde transport. The gene is expressed in adult and fetal tissues, including brain and heart. This gene is a component of the 2q13 deletion syndrome. Mutations in this gene may be associated with congenital heart defects. [provided by RefSeq, Aug 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 1.9e-05 |
| Pick disease | 1894 | 1.8e-04 |
| osteosarcoma | 7950 | 2.7e-04 |
| ovarian cancer | 8520 | 2.2e-03 |
| medulloblastoma, large-cell | 6241 | 4.3e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 4.9e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.0e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.1e-02 |
| pituitary cancer | 1972 | 1.5e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.1e-02 |
| glioblastoma | 5792 | 2.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Restrictive cardiomyopathy | 11 | 3.874 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.300 | 1.9e-05 |
| glioblastoma | 1.200 | 2.7e-02 |
| intraductal papillary-mucinous adenoma (... | 1.500 | 6.0e-03 |
| intraductal papillary-mucinous carcinoma... | 1.500 | 1.1e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.900 | 2.1e-02 |
| medulloblastoma, large-cell | -1.600 | 4.3e-03 |
| osteosarcoma | 1.854 | 2.7e-04 |
| ovarian cancer | -1.400 | 2.2e-03 |
| pancreatic ductal adenocarcinoma liver m... | 1.572 | 4.9e-03 |
| Pick disease | 1.100 | 1.8e-04 |
| pituitary cancer | -1.100 | 1.5e-02 |
MVAACRSVAGLLPRRRRCFPARAPLLRVALCLLCWTPAAVRAVPELGLWLETVNDKSGPLIFRKTMFNST 1 - 70 DIKLSVKSFHCSGPVKFTIVWHLKYHTCHNEHSNLEELFQKHKLSVDEDFCHYLKNDNCWTTKNENLDCN 71 - 140 SDSQVFPSLNNKELINIRNVSNQERSMDVVARTQKDGFHIFIVSIKTENTDASWNLNVSLSMIGPHGYIS 141 - 210 ASDWPLMIFYMVMCIVYILYGILWLTWSACYWKDILRIQFWIAAVIFLGMLEKAVFYSEYQNISNTGLST 211 - 280 QGLLIFAELISAIKRTLARLLVIIVSLGYGIVKPRLGTVMHRVIGLGLLYLIFAAVEGVMRVIGGSNHLA 281 - 350 VVLDDIILAVIDSIFVWFIFISLAQTMKTLRLRKNTVKFSLYRHFKNTLIFAVLASIVFMGWTTKTFRIA 351 - 420 KCQSDWMERWVDDAFWSFLFSLILIVIMFLWRPSANNQRYAFMPLIDDSDDEIEEFMVTSENLTEGIKLR 421 - 490 ASKSVSNGTAKPATSENFDEDLKWVEENIPSSFTDVALPVLVDSDEEIMTRSEMAEKMFSSEKIM 491 - 555 //
