Tbio TMEM59L Transmembrane protein 59-like

Protein Summary

Description

Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding. This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UK28

Gene Name

• TMEM59L

Ensembl ID

• ENST00000262817
• ENSP00000262817
• ENSG00000105696
• ENST00000600490
• ENSP00000470879

Symbol

• BSMAP
• C19orf4
• BSMAP
• C19orf4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor	0.74
virus perturbation	0.68
cell type or tissue	0.59
histone modification site profile	0.54
cell line	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.57   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.57   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0