Tdark TMEM225 Transmembrane protein 225

Protein Summary

Description

Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC.

Uniprot Accession IDs

• Q6GV28

Gene Name

• TMEM225

Ensembl ID

• ENST00000375026
• ENSP00000364166
• ENSG00000204300

Symbol

• PMP22CD
• PMP22CD
• SPATA47
• PPP1R154

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.92
gene perturbation	0.71
tissue	0.65
cell line	0.54
disease perturbation	0.43

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.45   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 3   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.45   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 3   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0