| Tdark | Transmembrane protein 150C |
Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception.
This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]
This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8297 | 3.7e-08 |
| astrocytoma | 1113 | 5.5e-07 |
| pituitary cancer | 1915 | 2.0e-05 |
| cystic fibrosis | 1629 | 8.6e-05 |
| medulloblastoma, large-cell | 6086 | 1.1e-04 |
| atypical teratoid / rhabdoid tumor | 4971 | 2.5e-04 |
| adrenocortical carcinoma | 1385 | 9.8e-04 |
| posterior fossa group A ependymoma | 456 | 1.3e-03 |
| head and neck cancer | 263 | 2.1e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2902 | 2.3e-03 |
| osteosarcoma | 7766 | 1.8e-02 |
| glioblastoma | 5635 | 1.8e-02 |
| Breast cancer | 3469 | 3.0e-02 |
| aldosterone-producing adenoma | 646 | 3.1e-02 |
| oligodendroglioma | 2768 | 3.9e-02 |
| medulloblastoma | 702 | 4.6e-02 |
| adult high grade glioma | 3701 | 4.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.894 | 9.8e-04 |
| adult high grade glioma | -1.600 | 4.9e-02 |
| aldosterone-producing adenoma | -1.890 | 3.1e-02 |
| astrocytoma | -1.100 | 5.5e-07 |
| atypical teratoid / rhabdoid tumor | -2.800 | 2.5e-04 |
| Breast cancer | 2.600 | 3.0e-02 |
| cystic fibrosis | 1.980 | 8.6e-05 |
| glioblastoma | -1.200 | 1.8e-02 |
| head and neck cancer | -1.200 | 2.1e-03 |
| intraductal papillary-mucinous carcinoma... | -2.500 | 2.3e-03 |
| medulloblastoma | -1.400 | 4.6e-02 |
| medulloblastoma, large-cell | -4.800 | 1.1e-04 |
| oligodendroglioma | -2.300 | 3.9e-02 |
| osteosarcoma | -1.640 | 1.8e-02 |
| ovarian cancer | -3.400 | 3.7e-08 |
| pituitary cancer | -1.800 | 2.0e-05 |
| posterior fossa group A ependymoma | 1.200 | 1.3e-03 |
