Tbio TMEM14B Transmembrane protein 14B

Protein Summary

Description

Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.

Uniprot Accession IDs

• Q9NUH8
• Q5THN7
• Q5THN8
• Q96IX7
• Q9BVN8

Gene Name

• TMEM14B

Ensembl ID

• ENST00000379530
• ENSP00000368845
• ENSG00000137210
• ENST00000379542
• ENSP00000368858

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.68
tissue sample	0.66
histone modification site profile	0.65
tissue	0.58
cell line	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.8   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 26   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.8   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0