Tdark TMEM138 Transmembrane protein 138

Protein Summary

Description

Required for ciliogenesis. This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• Q9NPI0
• A6NGA7
• B4E044
• Q5JPE1

Gene Name

• TMEM138

Ensembl ID

• ENST00000278826
• ENSP00000278826
• ENSG00000149483
• ENST00000542946
• ENSP00000445792

Symbol

• HSPC196

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
tissue	0.72
transcription factor binding site profile	0.67
tissue sample	0.65
cellular component	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.87   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.87   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0