Tdark TMEM114 Transmembrane protein 114

Protein Summary

Description

This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract disorders. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• B3SHH9

Gene Name

• TMEM114

Ensembl ID

• ENST00000620492
• ENSP00000484263
• ENSG00000232258

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.65
transcription factor binding site profile	0.46
chemical	0.41
cellular component	0.38
gene perturbation	0.37

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 12   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0