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  5. Transmembrane emp24 domain-containing protein 4

Tbio Transmembrane emp24 domain-containing protein 4

Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity).

 Comments

Property Summary

NCBI Gene PubMed Count 12
PubMed Score 61.89
PubTator Score 1.45

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Expression

  Differential Expression (15)

Disease log2 FC p
adrenocortical carcinoma -1.150 9.6e-04
adult high grade glioma 1.600 2.2e-04
atypical teratoid / rhabdoid tumor 1.800 9.5e-06
ependymoma 1.100 1.2e-05
glioblastoma 1.700 2.7e-04
group 3 medulloblastoma 1.100 5.9e-03
intraductal papillary-mucinous adenoma (... -1.300 3.1e-04
intraductal papillary-mucinous carcinoma... -1.600 5.1e-05
intraductal papillary-mucinous neoplasm ... 1.100 1.3e-03
lung carcinoma 1.100 1.6e-28
medulloblastoma, large-cell 1.500 4.6e-04
osteosarcoma 2.206 5.2e-07
ovarian cancer -2.200 9.0e-07
primitive neuroectodermal tumor 1.100 2.7e-04
tuberculosis 1.100 8.3e-05

Synonym

Accession Q7Z7H5 A4D2K8 B4DFJ4 Q56VW3 Q7Z432 Q8N2P6
Symbols HNLF
ERS25
p24a3
GMP25iso
p24alpha3

Gene

TMED4

PANTHER Protein Class (2)

  Ortholog (10)

Species Source Disease
Inparanoid OMA
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA

 UniProt Keyword (12)

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 GO Function (1)

 GO Component (3)

 GO Process (2)

 Compartment GO Term (22)

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 HCA RNA Cell Line (56)

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 CSPA Cell Line (25)

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Gene RIF (2)

AA Sequence 

MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLP      1 - 70
STPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEH     71 - 140
ANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTG    141 - 210
IWQMRHLKSFFEAKKLV                                                         211 - 227
//

Text Mined References (17)

PMID Year Title