Protein Summary
Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).
- ENST00000267115
- ENSP00000267115
- ENSG00000139644
- ENST00000395006
- ENSP00000378454
- ENST00000423828
- ENSP00000389277
- ENST00000549385
- ENSP00000448036
- ENST00000552370
- ENSP00000450158
- ENST00000552699
- ENSP00000446734
- BI1
- TEGT
- BI-1
- TEGT
- BAXI1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.97 | ||
transcription factor binding site profile | 0.93 | ||
co-expressed gene | 0.87 | ||
disease perturbation | 0.83 | ||
transcription factor perturbation | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1000.63 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 203 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1000.63 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 203 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0