Property Summary

NCBI Gene PubMed Count 16
PubMed Score 154.43
PubTator Score 44.02

Knowledge Summary


No data available



  Differential Expression (1)

Disease log2 FC p
osteosarcoma -1.490 6.3e-06


Accession Q9HC24 Q542Z6 Q9UHY5 Q9Y3C2
Symbols S1R


  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (8)

25764978 These results suggest that the TMBIM family has comparable functions in the maintenance of intracellular Ca(2) homeostasis in a wide variety of tissues
23940116 The hGAAP is a novel regulator of focal adhesion dynamics, cell adhesion, and migration by controlling localized Ca(2+)-dependent activation of calpain.
23508950 GAAP can oligomerize in a pH-regulated manner, and monomeric GAAP is functional.
23000903 Taken together, the proposed interaction between Chlamydia pneumoniae protein CPn0809 and GAAP modulates bacterial growth in A549 cells.
22418439 Data indicate that GAAP and BI-1 have a six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop.
19553469 Data demonstrate that h-GAAP modulates intracellular Ca(2+) fluxes induced by both physiological and apoptotic stimuli.
18440869 The tmbim4 may participate in cell death regulation by interacting with proteins of Bcl-2 family, promoting tumor metastasis, which is deduced from the evolutionary conservation of the membrane protein family containing multiple membrane spanning segments
17319741 Stable expression of both viral GAAP (v-GAAP) and human GAAP (h-GAAP), which is expressed in all human tissues tested, inhibited apoptosis induced by intrinsic and extrinsic apoptotic stimuli

AA Sequence

VLAAISLYLDIINLFLHLLRFLEAVNKK                                              211 - 238

Text Mined References (18)

PMID Year Title
25764978 2015 The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²?-filling state.
23940116 2013 hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.
23508950 2013 Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium.
23000903 2013 Host cell Golgi anti-apoptotic protein (GAAP) and growth of Chlamydia pneumoniae.
22418439 2012 Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.
19784873 2009 LFG: a candidate apoptosis regulatory gene family.
19553469 2009 Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.
18440869 2008 Comparative genomics and function analysis on BI1 family.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
17319741 2007 A new inhibitor of apoptosis from vaccinia virus and eukaryotes.
16541075 2006 The finished DNA sequence of human chromosome 12.
16303743 2005 Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11042152 2000 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
10931946 2000 Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
10810093 2000 Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.