Tchem TLK1 Serine/threonine-protein kinase tousled-like 1

Protein Summary

Description

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q9UKI8
• B3KR15
• B4DX87
• Q14150
• Q8N591
• Q9NYH2
• Q9Y4F6

Gene Name

• TLK1

Ensembl ID

• ENST00000360843
• ENSP00000354089
• ENSG00000198586
• ENST00000431350
• ENSP00000411099
• ENST00000434911
• ENSP00000409222
• ENST00000521943
• ENSP00000428113

Symbol

• KIAA0137
• PKU-beta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.94
molecular function	0.91
transcription factor perturbation	0.8
microRNA	0.76
disease perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Serine/threonine-protein Kinase Tousled-like 1

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Tlk Family / Serine/threonine-protein Kinase Tousled-like 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.86   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 359   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.86   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0