| Tclin | Thyroid hormone receptor beta |
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 217 |
| NCBI Gene PubMed Count | 222 |
| PubMed Score | 627.31 |
| PubTator Score | 407.03 |
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1638 | 5.0e-18 |
| lung carcinoma | 2843 | 3.9e-17 |
| colon cancer | 1478 | 4.1e-09 |
| atypical teratoid / rhabdoid tumor | 5112 | 7.8e-09 |
| cystic fibrosis | 1696 | 2.1e-06 |
| osteosarcoma | 7950 | 2.2e-06 |
| medulloblastoma, large-cell | 6241 | 2.4e-06 |
| invasive ductal carcinoma | 2951 | 1.1e-04 |
| group 3 medulloblastoma | 4104 | 2.4e-04 |
| head and neck cancer | 271 | 2.5e-04 |
| interstitial cystitis | 2312 | 2.6e-04 |
| primitive neuroectodermal tumor | 3035 | 2.8e-04 |
| psoriasis | 6694 | 4.3e-04 |
| glioblastoma | 5792 | 5.1e-04 |
| ductal carcinoma in situ | 1745 | 1.0e-03 |
| adult high grade glioma | 3801 | 2.4e-03 |
| lung cancer | 4740 | 2.6e-03 |
| astrocytic glioma | 2597 | 3.2e-03 |
| adrenocortical carcinoma | 1428 | 3.2e-03 |
| ovarian cancer | 8520 | 3.6e-03 |
| ulcerative colitis | 1819 | 1.0e-02 |
| Becker muscular dystrophy | 191 | 1.3e-02 |
| oligodendroglioma | 2850 | 1.3e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.8e-02 |
| hereditary spastic paraplegia | 318 | 2.2e-02 |
| ependymoma | 4679 | 4.0e-02 |
| Breast cancer | 3578 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Peripheral vascular disease | 87 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Thyrotoxicosis | 38 | 5.167 | 2.6 |
| Hyperthyroxinemia | 9 | 4.406 | 2.2 |
| Enhanced S-cone syndrome | 17 | 3.609 | 1.8 |
| Radial neuropathy | 3 | 3.429 | 1.7 |
| Cancer | 2499 | 3.4 | 1.7 |
| Graves' disease | 24 | 3.396 | 1.7 |
| Pituitary adenoma | 38 | 3.007 | 1.5 |
| Disease | Target Count |
|---|---|
| Generalized resistance to thyroid hormone | 1 |
| Peripheral resistance to thyroid hormones | 2 |
| Sickle Cell Anemia | 53 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.811 | 3.2e-03 |
| adult high grade glioma | -2.400 | 2.4e-03 |
| astrocytic glioma | -2.200 | 3.2e-03 |
| atypical teratoid / rhabdoid tumor | -4.600 | 7.8e-09 |
| Becker muscular dystrophy | -1.040 | 1.3e-02 |
| Breast cancer | -1.100 | 4.4e-02 |
| breast carcinoma | -1.300 | 5.0e-18 |
| colon cancer | -2.400 | 4.1e-09 |
| cystic fibrosis | -3.066 | 2.1e-06 |
| ductal carcinoma in situ | -1.600 | 1.0e-03 |
| ependymoma | -2.200 | 4.0e-02 |
| glioblastoma | -1.900 | 5.1e-04 |
| group 3 medulloblastoma | -4.300 | 2.4e-04 |
| head and neck cancer | -1.200 | 2.5e-04 |
| hereditary spastic paraplegia | -1.034 | 2.2e-02 |
| interstitial cystitis | -2.200 | 2.6e-04 |
| intraductal papillary-mucinous adenoma (... | 1.400 | 1.8e-02 |
| invasive ductal carcinoma | -1.676 | 1.1e-04 |
| lung cancer | -1.100 | 2.6e-03 |
| lung carcinoma | -1.300 | 3.9e-17 |
| medulloblastoma, large-cell | -5.500 | 2.4e-06 |
| oligodendroglioma | -1.800 | 1.3e-02 |
| osteosarcoma | 1.254 | 2.2e-06 |
| ovarian cancer | 1.200 | 3.6e-03 |
| primitive neuroectodermal tumor | -3.700 | 2.8e-04 |
| psoriasis | 1.200 | 4.3e-04 |
| ulcerative colitis | -1.300 | 1.0e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
CHEMBL260482
pEC50 7.00
CHEMBL3261336
pEC50 7.05
CHEMBL110158
pKd 7.05
CHEMBL97613
pKd 7.05
CHEMBL485927
pKi 7.05
CHEMBL447378
pKi 7.06
CHEMBL250513
pIC50 7.06
CHEMBL120587
pIC50 7.06
CHEMBL236864
pIC50 7.06
CHEMBL235166
pIC50 7.08
CHEMBL2312274
pKi 7.09
CHEMBL119976
pIC50 7.11
CHEMBL124145
pIC50 7.12
CHEMBL236863
pIC50 7.12
CHEMBL122583
pIC50 7.15
CHEMBL238179
pIC50 7.17
CHEMBL398571
pIC50 7.17
CHEMBL237936
pIC50 7.17
CHEMBL258886
pKd 7.17
CHEMBL3126376
pEC50 7.21
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHL 1 - 70 DHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLH 71 - 140 PSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGH 141 - 210 KPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAI 211 - 280 TRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVS 281 - 350 DAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK 351 - 420 LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 421 - 461 //
