| Tclin | Tyrosine 3-monooxygenase |
Plays an important role in the physiology of adrenergic neurons.
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 4 |
| NCBI Gene PubMed Count | 210 |
| PubMed Score | 2144.65 |
| PubTator Score | 1081.75 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neuroblastoma | 80 | 4.669 | 2.3 |
| Hypertension | 396 | 3.243 | 1.6 |
| Brain Diseases | 24 | 0.0 | 0.0 |
| Carcinoma, Hepatocellular | 228 | 0.0 | 0.0 |
| Catalepsy | 15 | 0.0 | 0.0 |
| Dyskinesia, Drug-Induced | 15 | 0.0 | 0.0 |
| Dystonia | 164 | 0.0 | 4.0 |
| Heart Diseases | 43 | 0.0 | 0.0 |
| Hyperkinesis | 32 | 0.0 | 0.0 |
| Intellectual disability | 1016 | 0.0 | 0.0 |
| Learning Disorders | 29 | 0.0 | 0.0 |
| Nerve Degeneration | 121 | 0.0 | 0.0 |
| Parkinsonian Disorders | 56 | 0.0 | 0.0 |
| Segawa Syndrome, Autosomal Recessive | 1 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Pheochromocytoma | 24 |
| Disease | Target Count | P-value |
|---|---|---|
| adrenocortical carcinoma | 1428 | 3.0e-04 |
| interstitial cystitis | 2312 | 1.2e-03 |
| aldosterone-producing adenoma | 665 | 1.1e-02 |
| adrenocortical adenoma | 131 | 1.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Type 1 diabetes mellitus | 109 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Parkinson's disease | 392 | 7.726 | 3.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Toxic encephalopathy | 141 | 5.764 | 2.9 |
| Brain disease | 96 | 4.222 | 2.1 |
| Schizophrenia | 1160 | 4.085 | 2.0 |
| Hyperprolactinemia | 27 | 3.848 | 1.9 |
| Multiple system atrophy | 29 | 3.602 | 1.8 |
| Attention deficit hyperactivity disorder | 278 | 3.213 | 1.6 |
| Sudden infant death syndrome | 32 | 3.054 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical adenoma | -1.768 | 1.4e-02 |
| adrenocortical carcinoma | -1.762 | 3.0e-04 |
| aldosterone-producing adenoma | -3.578 | 1.1e-02 |
| interstitial cystitis | -1.100 | 1.2e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTPRSPRFIGRRQ 1 - 70 SLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAK 71 - 140 IHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKCHHL 141 - 210 VTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACG 211 - 280 EHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASS 281 - 350 PMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYG 351 - 420 AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKF 421 - 490 DPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG 491 - 528 //
