Tchem | TGF-beta receptor type-2 |
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
Comments
Property Summary
Ligand Count | 9 |
NCBI Gene PubMed Count | 438 |
PubMed Score | 665.12 |
PubTator Score | 615.96 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
pancreatic cancer | 2398 | 0.0 | 0.6 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Breast cancer | 3578 | 0.0 | 1.80998606902936E-15 |
Dental caries | 164 | 0.0 | 1.0 |
Migraine | 83 | 0.0 | 3.0 |
Type 2 diabetes mellitus | 272 | 0.0 | 1.0 |
Vascular disease | 319 | 0.0 | 2.4 |
Disease | Target Count |
---|---|
Lynch syndrome | 35 |
Familial thoracic aortic aneurysm and aortic dissection | 13 |
Thoracic aortic aneurysm | 15 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
CHEMBL2385582
pIC50 7.59
CHEMBL2385600
pIC50 7.80
CHEMBL2385596
pIC50 7.82
CHEMBL2385579
pIC50 8.86
compound 13a [PMID: 23639540]
pIC50 8.86
compound 13d [PMID: 23639540]
pIC50 7.59
compound 15b [PMID: 16539403]
pIC50 6.45
galunisertib
pIC50 6.68
LY2109761
pKi 6.52
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSN 1 - 70 CSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSS 71 - 140 DECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLM 141 - 210 EFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP 211 - 280 YEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKL 281 - 350 GSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG 351 - 420 TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDN 421 - 490 VLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPED 491 - 560 GSLNTTK 561 - 567 //