Tbio TGFB1I1 Transforming growth factor beta-1-induced transcript 1 protein

Protein Summary

Description

Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• O43294
• B2R8D5
• Q9BPW3
• Q9Y2V5

Gene Name

• TGFB1I1

Ensembl ID

• ENST00000361773
• ENSP00000355117
• ENSG00000140682
• ENST00000394858
• ENSP00000378327
• ENST00000394863
• ENSP00000378332
• ENST00000567607
• ENSP00000457586

Symbol

• ARA55
• HIC5
• ARA55
• HIC-5
• TSC-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
biological process	0.92
PubMedID	0.84
gene perturbation	0.76
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Transforming Growth Factor Beta-1-induced Transcript 1 Protein

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Transforming Growth Factor Beta-1-induced Transcript 1 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.15   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 224   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 119.15   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0