Property Summary

NCBI Gene PubMed Count 3,362
PubMed Score 20956.55
PubTator Score 14221.43

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count
Cleft palate 125
Myopathy 128
Oral Submucous Fibrosis 18
Acromicric Dysplasia 5
Acute Lung Injury 18
Acute kidney injury 65
Adenocarcinoma 115
Aortic valve insufficiency 22
Berylliosis 28
Camurati-Engelmann Syndrome 1
Carcinosarcoma 6
Cerebrovascular accident 44
Chronic Obstructive Airway Disease 47
Colorectal Cancer 62
Colorectal Neoplasms 217
Copper-Overload Cirrhosis 11
Diabetes Mellitus, Experimental 106
Diabetes Mellitus, Non-Insulin-Dependent 161
Diabetic Nephropathy 37
Diabetic Neuropathies 13
Diaphragmatic Hernia 40
Dry Eye Syndromes 2
Duodenal ulcer 20
Endomyocardial Fibrosis 10
Fibrosis 40
Focal glomerulosclerosis 22
Hepatitis, Autoimmune 17
Hepatitis, Chronic 22
Hyperplasia 26
Hypersensitivity 63
Hypertensive disease 193
IGA Glomerulonephritis 454
Inflammation 109
Intervertebral Disc Degeneration 5
Kidney Diseases 86
Kidney Failure, Chronic 45
Liver Cirrhosis 101
Liver Cirrhosis, Alcoholic 16
Liver Cirrhosis, Experimental 108
Liver carcinoma 217
Lung Neoplasms 171
Lung diseases 48
Migraine Disorders 26
Muscular Dystrophy, Duchenne 7
Myocardial Infarction 126
Neoplasm Invasiveness 127
Neoplasm Metastasis 138
Neoplastic Cell Transformation 81
Nephrotic Syndrome 48
Non-alcoholic Fatty Liver Disease 40
Osteoporosis, Postmenopausal 7
Pancreatic Neoplasm 79
Papilloma 27
Peritoneal Fibrosis 1
Peyronie Disease 1
Prostatic Neoplasms 471
Proteinuria 63
Pulmonary Fibrosis 66
Pulmonary emphysema 34
Sepsis 21
Skin Neoplasms 49
Spontaneous abortion 108
Squamous cell carcinoma 96
Thrombocythemia, Essential 12
Uremia 19
Ureteral obstruction 6
Urticaria 53
Ventricular Remodeling 5
Disease Target Count Z-score Confidence
Cancer 2346 6.938 3.5
Kidney disease 397 6.682 3.3
Lung disease 136 6.055 3.0
Ureteral disease 23 5.741 2.9
Hypersensitivity reaction type II disease 235 5.524 2.8
Collagen disease 25 5.414 2.7
Liver disease 219 5.26 2.6
Arthritis 248 5.21 2.6
diabetes mellitus 1663 5.189 2.6
Hypertension 293 5.076 2.5
Hereditary hemorrhagic telangiectasia 14 4.927 2.5
Inflammatory bowel disease 142 4.916 2.5
Heart disease 279 4.735 2.4
Atherosclerosis 275 4.496 2.2
Loeys-Dietz syndrome 23 4.379 2.2
Multiple Sclerosis 498 4.331 2.2
Allergic hypersensitivity disease 123 4.294 2.1
Coronary artery disease 240 4.273 2.1
Peyronie's disease 8 4.259 2.1
Proliferative vitreoretinopathy 17 4.205 2.1
Leishmaniasis 49 4.134 2.1
Pancreatitis 97 4.007 2.0
Glaucoma 135 3.998 2.0
Hyperglycemia 120 3.93 2.0
Periodontal disease 37 3.921 2.0
tuberculosis 1563 3.905 2.0
Obesity 616 3.654 1.8
Dermatitis 141 3.639 1.8
Aortic aneurysm 34 3.631 1.8
Cerebrovascular disease 231 3.573 1.8
Hepatitis C 90 3.538 1.8
Cholestasis 93 3.454 1.7
Chronic fatigue syndrome 29 3.443 1.7
Peripheral vascular disease 90 3.385 1.7
Adenoma 165 3.358 1.7
Schistosomiasis 38 3.349 1.7
Diabetic Retinopathy 53 3.348 1.7
Allergic rhinitis 92 3.338 1.7
Human immunodeficiency virus infectious disease 129 3.333 1.7
Eosinophilia 65 3.328 1.7
Endometriosis 535 3.301 1.7
Hepatitis B 103 3.217 1.6
Portal hypertension 21 3.18 1.6
Common cold 63 3.176 1.6
Malaria 140 3.149 1.6
Retinal detachment 33 3.107 1.6
Marfan Syndrome 14 3.101 1.6
Neuropathy 210 3.095 1.5
Alzheimer's disease 644 3.089 1.5
Peritonitis 37 3.03 1.5
Corneal disease 32 3.024 1.5

Expression

  Differential Expression (15)

Disease log2 FC p
malignant mesothelioma 1.100 6.0e-05
astrocytic glioma 1.700 3.7e-03
ependymoma 1.400 2.6e-02
glioblastoma 2.800 1.5e-05
osteosarcoma 1.297 1.9e-02
atypical teratoid / rhabdoid tumor 1.200 2.0e-03
medulloblastoma 1.300 1.6e-02
primary pancreatic ductal adenocarcinoma 1.560 3.9e-03
diabetes mellitus -1.700 5.7e-03
pediatric high grade glioma 2.100 1.6e-05
pilocytic astrocytoma 2.000 5.9e-07
lung carcinoma -1.700 6.7e-19
gastric carcinoma 1.600 6.1e-03
ulcerative colitis 1.800 1.4e-03
pancreatic cancer 1.500 3.3e-03
See source...

 GWAS Trait (1)

Gene RIF (3473)

PMID Text
27534050 The maximum risk for Pulmonary tuberculosis is associated with a combination of the AA genotypes of the polymorphic site +874A/Tof the IFNG gene and TT polymorphism G509T of the TGFB gene (AA/TT).
27455564 The involvement of TGF-beta in pathogenesis of Marfan's syndrome permits considering ACE antagonists as potential pharmaceuticals in therapy for this disease. (Review)
27215961 Considering the low frequency of TGF-beta1 G allele at codon 25 as well as TGF-beta1 CT genotype at codon 10 in patients with juvenile idiopathic arthritis, it seems that these cytokine gene polymorphisms could play role as the protective factors against JIA.
27215079 distribution of the C/T polymorphism of TGFB1 between healthy individuals and patients were obtained as TT: 22.4%, TC: 46%, CC: 31.6%, and TT: 19.1%, TC: 48.3%, CC: 32.6%, respectively
27181170 Serum TGF-beta1 in patients with acute myocardial infarction.
27143355 The current study describes a novel mechanism linking the TSG-6 transfer of the newly described HC5 to the HA-dependent control of cell phenotype. The interaction of HC5 with cell surface HA was essential for TGFbeta1-dependent differentiation of fibroblasts to myofibroblasts, highlighting its importance as a novel potential therapeutic target.
27129231 TGF-beta1 may contribute to hepcidin synthesis during iron overload.
27100181 High TGFB1 expression is associated with Colon Adenomas.
27097224 Urine TGF-beta1 and collagen-IV were significantly higher in albuminuric compared to non-albuminuric participants with HIV infection
27093792 There was a trend to higher fibrosis progression rate in Chronic Hepatitis C patients with mutant alleles and genotypes of TGFb +915 G/C.
27049572 The results of this study revealed significant predominance of TGF-beta TT (+869) genotype (previously described as predicting low expression activity of TGF-beta) in patients (41.3%) compared to healthy subjects (21.2%.
27040591 Pulsed electrical stimulation promotes wound healing by activating skin fibroblasts through the TGFbeta1/ERK/NF-kappaB axis.
27022914 high levels of PAI-1 are detected when D allele is present, whereas greater interdialytic gain is associated with the presence of I allele.
27015414 RAGE and TGF-beta1 are both involved in fibrosis development in a complex cross-talk mechanism, while also acting on their own individual targets
26987776 a functional conservation of miR-122 in the TGFbeta pathway, is reported.
26983758 B2M is a potential tissue biomarker and therapeutic target of borderline and malignant ovarian tumours and the dysregulation of B2M in these tumours may be mediated by the TGF-beta signaling pathway.
26974954 data suggest that TGF-beta1 enhances IGFBP7 via Smad2/4 pathways, and that IGFBP7 might be involved in the TGF-beta1-induced tubular injury in DN.
26966064 These results for the first time demonstrate a role of Cdk5/p35 in the regulation of cell cycle progression modulated by TGF-beta1.
26956674 These findings indicate that M3 mAChR may be important therapeutic target for obstructive airway diseases, as it regulates the effects of the epithelial-derived chemokines on ASM cell migration, which results in lung remodeling.
26950997 In periodontitis, TLR2 gene hyperexpression was accompanied by the reduction of expression of anti-microbial peptide HBD-2, as well as in an increase of production of TNF-alpha and TGF-beta by epithelial cells of periodontium mucosa.
26932661 IL-27 attenuates epithelial-mesenchymal transition in alveolar epithelial cells in the absence or presence of TGF-beta1 through the JAK/STAT and TGF-beta/Smad signalling pathways.
26927558 Data indicate that in recurrent spontaneous abortion patients, the expression levels of CD49b and LAG-3 (CD223) on CD14(+) mononuclear cells and the plasma level of transforming growth factor beta (TGF-beta) decreased obviously compared with normal females.
26921108 increased expression in alveolar macrophages in Idiopathic pulmonary fibrosis patients
26918958 LTBP4 protein with the IAAM residues bound more latent TGFbeta compared to the LTBP4 VTTT protein. Its differential avidity for TGFbeta accounting for the differences in TGFbeta signaling attributed to these two alleles.
26915797 TGFBIp expression is positively regulated by TGF-beta1 in corneal fibroblasts, whereas TGF-beta1-induced miR-21 and miR-181a negatively regulate TGFBIp expression.
26909983 The gradual increase of CTGF and TGF-beta1 expression levels in liver tissue is associated with liver fibrosis. Early expression of CTGF and TGF-beta1 in biliary epithelial cells may be involved in the pathogenesis of congenital biliary atresia.
26901047 Meta-analysis suggested that elevated serum TGF-beta level in patients with diabetes is associated with a high risk of nephropathy
26884601 constitutive TGF-beta signaling or depletion of mTOR arrested NK cell development, whereas deletion of the TGF-beta receptor subunit TGF-betaRII enhanced mTOR activity and the cytotoxic activity of the NK cells in response to IL-15.
26867650 Data suggest novel mechanism in innate immunity allows cytokine TGF-beta to restrict viral circular DNA in hepatocyte nuclei via innate immunity; AID deaminates circular DNA of hepatitis B virus leading to DNA degradation; mechanism depends on UNG.
26849902 This review will discuss the recent findings on the mechanisms and role of TGF-beta in membranous and diabetic nephropathy.
26847457 TGF-beta1 expression inversely correlated with ankle-brachial index across peripheral artery disease patients.
26846663 Although TGF-beta1 signaling in gastric cancer cells appears hyper-activated in i-GC compared to d-GC, the Smad-dependent pathway seems down-regulated while the Smad-independent pathway seems up-regulated in both histologic subtypes.
26830674 Overexpression of TGF-beta and sox9 enhanced the levels of cell proliferation, matrix biosynthesis, and chondrogenic differentiation in human mesenchymal stem cells.
26829554 Plasma levels of IL-10, TGFbeta and IL-17 are significantly correlated with parasite load in Visceral leishmaniasis patients.
26820528 The results clearly indicated that GRe is the effective constituent in the ginseng on hair promotion via selective inhibition of the hair growth phase transition related signaling pathways, TGF-beta signaling cascades.
26805406 IFN-gamma and/or TNF-alpha primed adipose tissue mesenchymal stem cells might enhance the malignancy of MCF-7 cell line by inducing epithelial to mesenchymal transition, cell motility and uPA expression in these cells via TGF-beta1 signaling.
26801303 Monocytes increase myofibroblast ECM remodeling via TGFB1 signaling.
26784546 TGF-beta/beta2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome.
26769181 Data show that miR106b was frequently up-regulated in human cervical carcinoma tumors and cell lines and inversely correlated with DAB2 expression. Its regulation in under TGF-beta1 which contributes to cell migration by targeting DAB2 in cervical carcinoma.
26769004 the role of TGFbeta in the progression of osteogenic differentiation in primary dermal fibroblasts from five classical Fibrodysplasia ossificans progressiva patients, was studied.
26758901 In a Chinese population, the TGFB1 gene was found to play a role in the curve progression of patients with adolescent idiopathic scoliosis.
26751072 TGFB1 induces a fibrotic phenotype in lung fibroblasts that is counteracted by targeting the proteoglycan synthesis pathway
26749573 TGF-beta1 could induce the expressions of Fascin1 mRNA and protein and thus improve the invasive and metastatic ability of human renal carcinoma cells.
26730582 Strongyloidiasis infection is characterized by an IL-10- and TGFbeta dependent expansion of Th9 cells, an expansion found to reversible by anti-helmintic treatment.
26719248 The authors showed that hepatitis C virus E2 protein triggers the production of TGF-beta1 by hepatitis C virus-infected cells through overproduction of glucose-regulated protein 94 (GRP94).
26717894 TGF-beta1 is a direct target of miR-663. TGF-beta1 expression is negatively mediated by miR-663 at the post-transcriptional level in glioblastoma cells.
26708185 correlation between TGFb1 and pSmad2 as well as between HtrA1 and TGFb1 and the very significant increase of Ki67 in stromal compartment of eutopic endometrium suggest a possible involvement of HtrA1 in the pathogenesis of endometriosis.
26682928 Overall, our study found that miR-181c plays a key role in glioblastoma cell invasion, migration and mesenchymal transition suggesting potential therapeutic applications.
26675296 TGF-beta plays a critical role in initiating expressions of pluripotent transcription factor OCT4 which may contribute to the ectopic endometrial growth.
26656423 Our data support a gene-environment interaction between food and genotype at C-509 that modulates disease severity in eosinophilic esophagitis
26653761 TGFbeta signaling via both SMAD2/7 and PARD6/SMURF1 pathways plays a role in trophoblast growth and differentiation.
26648552 targeting JNK signaling favors TGF-beta to block HBx-induced cell growth promotion in well-differentiated HCC cells. As an adjunct to anti-viral therapy, the combination of TGF-beta and inhibition of JNK signaling is a potential therapy for HBV-infected HCC.
26648305 Overexpression of miR-1908 suppressed the expressions of TGF-beta1, smad2/3 and MMP-2 in human primary renal interstitial cells.
26647993 The present study thus proposed SEB as an agent able to significantly reduce Smad2/3 expression in colon cancer cells, provoking moderate TGFb growth signaling and the reduction of tumor cell proliferation.
26647384 TGFB signaling regulates epithelial-mesenchymal plasticity in ovarian cancer ascites-derived spheroids
26637634 that prenatal tracheal occlusion increases TGF-beta/Rho kinase pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs
26637578 pirfenidone may inhibit TGF-beta1-induced extracellular matrix by regulating Smad2/3.
26634652 Aortic valve endothelial cell derived Tgfb1 signaling promotes nuclear localization of Sox9 in interstitial cells, attenuating aortic valve calcification.
26632599 elongation of cultured dermal fibroblasts can induce a predominant tenogenic phenotype likely via synergistic effect of TGF-beta and cytoskeletal signaling
26627200 TGF-beta could induce HLA-G expression in GC by inhibiting miR-152, involving its negative regulation on HLA-G
26616407 P311 plays a key role in renal fibrosis via TGFbeta1/Smad signaling, which could be a novel target for the management of renal fibrosis.
26611114 observations suggest IRF3 may function as a novel regulator to modulate TGF-beta1-induced LX-2 proliferation, at least in part, via AKT signaling pathway
26598524 TGFbeta induces autophagy through the pRb/E2F1 pathway and transcriptional activation of autophagy-related genes
26597739 The results of this study suggest that TGF-beta1 gene 788C-->T polymorphism is an important factor mediating the casual pathway of preeclampsia.
26597083 TGF-beta and PTHrP were confirmed to be involved in regulating the malignant progression in breast cancer, and PTHrP expression, to be associated with bone metastasis as a potential prognostic marker in ER negative breast cancer
26596284 Loss of CDKN2B may not only promote cardiovascular disease through the development of atherosclerosis but may also impair TGFbeta signaling and hypoxic neovessel maturation.
26592459 Studies indicate crosstalk between Notch receptor and Wnt protein, Hedgehog protein, hypoxia and transforming growth factor beta (TGFbeta)/bone morphogenetic protein (BMP) pathways.
26592197 NLRC5 regulates TGFB1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis.
26586478 Data suggest that targeting both TGF-beta and Janus kinase 1 (JAK1) signaling could be explored therapeutically in pancreatic ductal adenocarcinomas (PDACs) patients whose cancers exhibit an angiogenesis gene signature.
26585689 Data suggest that transforming growth factor beta 1 (TGF-beta) is secreted by mesenchymal stem cells (MSCs), leading to force-dependent directional migration of invasive breast cancer cells.
26584734 since GARP functions as a transporter of transforming growth factor beta (TGFbeta), a cytokine with broad pleiotropic traits, GARP transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb
26583147 the level of TGFBR1 and early osteogenic differentiation were abolished in the DPSCs transfected with siRNA for GnT-V knockdown...GnT-V plays a critical role in the hexosamine-induced activation of TGF-b signaling and osteogenic differentiation
26577912 Peritoneal VEGF-A expression is regulated by TGF-beta1 through an ID1 pathway in women with endometriosis
26576674 that miR-449a suppressed Flot2 expression results in decreased cell invasion through repressing TGF-beta-mediated-epithelial-mesenchymal transition
26555259 These results shed new light on the regulation of TGF-beta signaling by Smad7.
26551914 Our results suggest that Gal1 and TGF-beta1 might function coordinately within the HCC microenvironment to regulate tumor growth, invasion, metastasis, and angiogenesis.
26541894 induces the differentiation of CXCL13-producing CD4+ T cells that lack typical follicular helper T cell features
26538547 Forced overexpression of Wnt7B with or without TGFB1 treatment increased Wnt5A protein expression in normal human smooth muscle cells and fibroblasts but not in Idiopathic Pulmonary Fibrosis myofibroblasts where Wnt5A was already highly expressed.
26518873 Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts.
26510436 REVIEW: update the relevant and differential roles of NOX isoforms during liver fibrosis and hepatocarcinogenesis, their cross-talk with the TGF-beta pathway and their potential as therapeutic targets for these diseases
26510396 our data not only contribute to clarifying the cellular processes governing pancreatic tissue regeneration, but also emphasize the conserved role of TGFbeta as a tumour suppressor.
26498464 Down-regulation of TGF-b1 is associated with skin lesions.
26487273 Halting pro-survival autophagy by TGF-beta inhibition in bone marrow fibroblasts overcomes bortezomib resistance in multiple myeloma patients.
26482896 TGF-beta1 induced epigenetic modification of GSN could alter the EMT process in breast cancer cells.
26461171 Higher levels of TGFB1 are associated with Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome Following Lung Transplantation.
26450853 analysis of TGF-beta isoforms in thirteen types of cancer
26445225 TGF-beta/Smad signalling pathway and VEGF-A participate in the pathogenesis of sarcoidosis.
26432637 findings reveal that TGFbeta1 induces a SP1- and SMAD3-dependent recruitment of histone modifying enzymes to the PLOD2 promoter other than the currently known TGFbeta1 downstream co-activators and epigenetic modifications
26424011 Relaxin Inhibits High Glucose-Induced Matrix Accumulation in Human Mesangial Cells by Interfering with TGFB1 Production and Mesangial Cells Phenotypic Transition
26417995 results demonstrated that the novel pathway H19/miR-675/TGF-beta1/Smad3/HDAC regulates osteogenic differentiation of hMSCs and may serve as a potential target for enhancing bone formation in vivo.
26406959 The overexpression of TGF-beta1 is associated with the occurrence of thyroid cancer, which can be used as a candidate for the diagnosis and prognosis of thyroid cancer.
26403398 HoxB7 is associated with tumor metastasis in patients with lung adenocarcinoma and HoxB7 may be implicated in promoting the development of lung adenocarcinoma through activation of the TGF-beta/SMAD3 signaling.
26403263 FGF2 may be redirecting fibroblasts towards an anti-fibrotic phenotype during wound healing by overriding TGFb1 mediated ITGA11 expression.
26402106 Carriers of Tlower allele showed significant short-term decline in cognitive and functional performance, while individuals with CChigher genotype of TGF-beta1 codon 10 T>C remained stable
26397987 mitochondrial dysfunction induces EMT through TGF-beta/Smad/Snail signaling via c-Jun/AP-1 activation.
26395178 Data show that the expression of transforming growth factor beta 1 (TGFB1) was correlated with the expression of SMA- and MAD-related protein 3 (SMAD3) and matrix metalloproteinase-13 (MMP13) in osteoarthritis (OA)-affected cartilage.
26383977 Relationship between Expression of TGF-beta1, Smad2, Smad4 and Prognosis of Patients with Resected Non-small Cell Lung Cancer
26376826 In summary, this study demonstrates a link between SphK1/sphingosine-1-phosphate and TGF-beta-induced miR-21 in renal tubular epithelial cells.
26370086 demonstrated that EAF2 suppresses both TGF-beta-induced G1 cell cycle arrest and TGF-beta-induced cell migration
26354330 MAPK and TGFB[Transforming Growth Factor beta1]/SMAD signaling pathway may be important molecular mechanism underlying the pathogenesis of endometriosis
26345917 HMGB-1, CXCL16, miRNA-30a, and urinary TGF-ss1 were highly expressed in PNS patients and may play important roles in the pathogenesis and development of PNS.
26345741 TGF-beta1 rs1800469 TT and rs2241715 TT homozygote genotypes represent the genetic factors underlying familial clustering of liver cancer in Guangxi.
26345253 TGF-beta1 pathway activation in nonsyndromic mitral valve prolapse induces valve interstitial cell differentiation into contractile myofibroblasts and is associated with changes in the molecular pattern of the adherens junction.
26343835 results provide evidence that TGF-beta1 and IL-10 could play an important role in the downregulation of HLA-I molecules on CeCa cells induced by tumor MSCs
26337071 We aimed to perform a meta-analysis to evaluate the relationship between TGF-beta1 polymorphisms and the susceptibility to CKD
26335400 TGF-beta1 signaling, loss of metabolic homeostasis and chronic low-grade inflammation appear to play important roles in the pathogenesis of fibrosis, along with oxidative stress and down-regulation of the antioxidant system. (Review)
26319660 we show for the first time the expression of FAP in activated fibroblasts after MI and its activation by TGFbeta1. Effects of FAP on fibroblast migration and gelatinolytic activity indicate a potential role in cardiac wound healing and remodeling.
26312490 A Short Peptide That Mimics the Binding Domain of TGF-beta1 Presents Potent Anti-Inflammatory Activity.
26311146 these findings suggest that TGFbetainduced release of soluble MICA leads to downregulation of NKG2D, thereby preventing NK cellmediated cytotoxicity toward renal proximal tubular epithelial cells in renal IRI
26306431 Transforming growth factor beta1 (TGF-beta1)plays important roles in such forms of organ fibrosis as cirrhosis, pulmonary fibrosis, glomerulosclerosis, cardiomyopathy, Crohn's disease, and scleroderma.
26298390 Our study uncovers the PITX2-induced expression of TGFB1/2/3 as well as INHBA genes (p < 0.01) followed by SMAD2/3-dependent TGF-b signalling pathway in ovarian cancer cells
26284758 Microarray analysis of gene expression at 8, 24, and 48 hours after SMAD4 expression characterized the regulatory impact of SMAD4 expression in a SMAD4-null pancreatic ductal adenocarcinoma cell line and identified novel targets of TGF-beta signaling.
26277914 The non-F508del homozygous mutation with TT genotype was associated to lung symptoms. This association was not found in the sub-groups with homozygous F508del. No association was found with the digestive, pancreatic and meconium ileus symptoms.
26271396 Activated TGF-beta1 is associated with Aggressiveness of Prostate Cancer.
26267811 MT has potentiating effect in TGF-beta1-induced EMT, independently of IDO. This nonimmunological effect of MT should be considered if IDO is the target to avoid immune escape in bladder cancer.
26265084 Different signaling pathways are involved in osteitis in CRS and are activated by the TGF-beta/Smad signaling pathway in CRSwNP versus the TGF-beta/Smad-independent signaling pathway in CRSsNP.
26261683 Suggest that TGF-beta1/Smad and Wnt/CTNNB1 signaling pathways both contribute to pathological scar formation.
26258650 TGFbeta target genes including TGFBI, BAMBI, COL3A1 and SERPINE1 are significantly increased in Diamond Blackfan Anemia induced pluripotent stem cells
26253191 NS1 interacts with KLF6 and modulates miR-24 expression and TGF-beta, which facilitates respiratory syncytial virus replication.
26249143 periostin may function as a novel regulator to modulate hepatic stellate cells activation, potentially by promoting the TGF-beta1/Smad signalling pathway.
26248335 Normal human lung epithelial cells inhibit TGF-beta induced myofibroblast differentiation via prostaglandin E2.
26239419 SHI reduced TGF-beta1induced collagen production through the ERK/Smad signalling pathway and attenuated TGF-beta1induced cell contraction by downregulating alpha-smooth muscle actin (alphaSMA) expression in the HSFs.
26239415 Data show that transforming growth factor beta 1 (TGF-beta1) expression was higher in gastric cancer in absence of Helicobacter pylori infection.
26239019 The results suggested a novel function for Twist in the promotion of EMT via TGF-b/Smad3 signaling pathway. Thus, Twist constitutes a potential therapeutic target in human cervical cancer.
26238954 The single nucleotide polymorphisms (SNP) rs1800469 in the TGFbeta1 promoter was found to significantly associate with late radiation effects in African Americans but not whites.
26235880 A dynamic alteration in TERT promoter occupancy by Snail and c-Myc is the mechanistic basis for TGF-beta-mediated regulation of TERT.
26226105 Provided a crosstalk between both pathways, Nrf2 and TGF-beta1 mutually promote their tumorigenic potential, a condition manifesting already at an early stage during inflammation induced carcinogenesis of the pancreas.
26222185 Data show that pyrrole-imidazole polyamide targeting transforming growth factor-beta1 (TGF-beta1) gene promoter region regulates the epithelial-mesenchymal transition EMT/MET process in MCF10A cells.
26218277 Arg25Pro (c.915G>C) polymorphism of TGFB1 gene suggests an association with increased risk for Hashimoto's thyroiditis
26212008 TGFbeta1-CXCR7 axis may be a prognostic marker and may provide novel targets for combinational therapies to be used in the treatment of advanced lung cancer in the future
26209277 PCDH1 and SMAD3 act in a single pathway in asthma susceptibility that affects sensitivity of the airway epithelium to TGF-beta.
26207300 we find mutation-specific differences in the processing of mutant TGFBIp species, which may contribute to the variable phenotypes noted in TGFBI-related dystrophies.
26205654 results suggest overexpression of TbetaRIII receptor restored TGF-beta1 sensitivity in CAL-27 cells
26202915 TGF-beta1 up-regulates Cx43 and increases gap junction intercellular communication activities (GJIC) in human granulosa cells
26201022 strong expression of TGF-beta1, IL-1beta and VEGF was evident in the extracellular matrix and in the cytoplasm of fibroblasts and myofibroblasts in Dupuytren's nodular tissues, as compared to control tissues
26198819 Pathogenesis of intracranial aneurysm is mediated by proinflammatory cytokine TNFA and IFNG and through stochastic regulation of IL10 and TGFB1 by comorbid factors.
26197481 a mouse model of R124H mutation of human TGFBI causes granular corneal dystrophy type 2
26194911 Collectively, the data argue that recessive dystrophic epidermolysis bullosa fibrosis is a consequence of a cascade encompassing tissue damage, TGF-beta-mediated inflammation, and matrix remodeling.
26187636 These data indicate that NF-kappaB/RelA controls a SMAD-independent gene network whose regulation is required for initiation of Type II EMT
26176983 the CCR7 axis mediates TGF-beta1-induced EMT via crosstalk with NF-kappaB signaling, facilitating lymph node metastasis and poorer overall survival in patients with gastric cancer
26173679 This investigation revealed a significant influence of TGFB1 C-509T and T869C polymorphisms on the Pre-eclampsia risk in South Indian women.
26163261 data showed that IkappaB-zeta-deficient T cells had a high capacity for generation of regulatory T cells (Tregs) when T cells were cultured under TGF-beta stimulation in the presence of cytokine-neutralizing antibodies
26158762 Data show that sorafenib inhibited microRNA miR-101 expression and enhanced dual specificity phosphatase 1 (DUSP1) expression and lowered transforming growth factor beta I (TGF-beta) release in M2 macrophage, slowing macrophage-driven hepatocarcinoma.
26152726 The cancer-driven alteration of WWP1 culminates in excessive TbetaRI degradation and attenuated TGFbeta1 cytostatic signaling, a consequence that could conceivably confer tumorigenic properties to WWP1.
26151690 IL-17A, IL-17F and IL23R polymorphisms have no effect on expression of IL-6, IL-17, IL-21 and TGF-beta1 mRNAs expression in H. pylori-infected gastritis.
26144293 Peripheral endothelin-1 and transforming growth factor-beta1 levels, which strongly correlate with their hepatic levels, reflect the stage of portal hypertension and liver insufficiency in cirrhosis.
26126825 LAPTM4B binds to GARP and is a negative regulator of TGF-beta1 production in human Tregs
26107172 TGF-beta has a role in inducing fibroblast activation and may be involved with the effect of areca nut in oral submucous fibrosis
26103587 increased TGF-beta1 concentrations in patients with sporadic DPAA in comparison to the reference subjects show a potential use of TGF-beta1 as a biomarker for the disease
26097586 TGF-beta1 expression was higher in fibrotic liver than that in normal liver. TGF-beta1 protein high expressing liver fibrosis showed alpha-SMA positive cells in the liver indicating activated hepatic stellate cells. TGF-beta1 and alpha-SMA expression were correlated.
26096938 Inhibin betaA is translationally regulated by TGFbeta via hnRNP E1.
26096876 Tamoxifen prevents TGF-beta1 mediated myofibroblast differentiation through ERK1/2 signaling pathway.
26090463 In donors significantly lower levels of IL-6, TNF-alpha, HGF, and TGF-beta were detected in portal blood compared to hepatic vein In patients with cirrhosis there were no significant differences of IL-6, TNF-alpha, and TGF-beta levels between portal and hepatic veins
26088859 PDGF and TGFbeta1 regulate acute respiratory distress syndrome-associated lung fibrosis through distinct signaling pathway-mediated activation of fibrosis-related proteins.
26088755 elevated TGF-beta1 and TGF-beta2 expression triggers invasion and migration by triple-negative breast cancer cells through the EMT process
26077733 Studied miR-34a expression levels in extrahepatic cholangiocarcinoma; found Smad4 over-expressed in most EHCC patients; activation of miR-34a suppressed invasion and migration through TGF-beta/Smad4 signaling pathway.
26077607 no relationship was found between TGF-beta concentration and the percentage of Treg cells in peripheral blood and tumors of the ovary
26077602 SET and MYND domain-containing protein 3 expression and TGF-beta1 expression in gastric cancer (GC) tissues were significantly and positively correlated. High expression levels of SMYD3 and TGF-beta1 can indicate poor prognoses for GC patients.
26076859 Frequency of the CC genotype at the TGFB/codon 10 (rs1982037) was underrepresented in febrile seizures patients compared to controls; TGFB at codon 25 (rs1800471) had no significant difference in allele frequencies between our patients and controls
26064986 Our findings suggest that TGF-beta1 and IL-10 polymorphisms are involved in complications and comorbidities in type 2 diabetes patients.
26060017 Data indicate the transforming growth factor beta (TGFbeta) signaling pathway as a downstream effector of integrin beta-like 1 (ITGBL1) and the transcription factor Runx2 as an upstream activator of ITGBL1 expression.
26059110 The T869C polymorphism in the TGFbeta1 gene is not associated with the pathogenesis of polycystic ovary syndrome.
26048435 the TGFB1 c.29C>T polymorphism significantly increases the risk of bladder cancer while c.74G>C, and +140A>G polymorphisms do not affect the same.
26045792 Review/Meta-analysis: TGFbeta1 869C/T polymorphism is a risk factor of radiation pneumonitis.
26045780 Histone acetyltransferase inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-beta1/Smad3 signaling pathway in vitro.
26041563 HGF and TGFbeta1 of bone-metastasis microenvironment acted co-ordinately, influencing non redundant pathways regulated by Twist program or Snail-transcription factor, with reversible MET switch
26039994 studies indicate that VEPH1 inhibits TGF-beta signaling by impeding the release of activated SMAD2 from TbetaRI and may modulate TGF-beta signaling during development and cancer initiation or progression
26036684 TGF-beta1-induced hair follicle outer root sheath keratinocytes (ORSKs) and normal skin epithelial cells underwent EMT in vitro with ORSKs exhibiting more obvious EMT changes
26035919 MAOA T941G and TNF-beta G252A gene polymorphisms appear to contribute to photophobia but not to osmophobia
26027897 In this study of the Chinese population, homozygosity of TGFB1 rs1800469-T and AGTR1 rs12695895-T might be associated with increased risk of abdominal aortic aneurysm
26025982 We also found that TGF-beta1 exposure modulates 8 chemokines and 18 cytokines, including TGF-beta1 and -beta2, and other important cytokines
26021267 These findings indicate that periostin is an important mediator of TGF-beta-induced epithelial mesenchymal transition.
26014037 TGF-beta downregulates KLRG1 expression in mouse and human CD8(+) T cells.
26012423 these findings suggest that TGF-beta suppression and EPO stimulation promote erythropoiesis of CD34(+)CD31(+) progenitor cells derived from hPSCs.
26009869 The results show that esophageal cancer-derived microvesicles are LAMP1 positive and carry MMP9.
26005723 TGF-beta1 induces epithelial-mesenchymal transition by the transactivation of epidermal growth factor signaling through Hyaluronan/CD44 in lung and breast cancer cells.
26002959 Data suggest MAID/CCNDBP1 inhibits cell migration induced by TGFB1 (transforming growth factor-beta1) but not by BMP4 (bone morphogenetic protein-4); MAID does not alter cell proliferation, epithelial-mesenchymal transition, or TGFB3-induced apoptosis.
25998442 role for mTORC2 in mediating TGF-beta/Activin signalling activities
25993872 IGF-II, TGF-beta1 and VEGF-A and its receptor in malignant tumor tissue, as well as increasedplasmin release from proenzyme and MMP-3 activationis apparently associated with the formation of pathogenic mechanism of vasculature development
25992978 the direct CD40-CD40L interaction of breast tumor cells and activated T cells increases TGF-beta production and the differentiation of Th17 cells, which promotes the proliferation of breast cancer cells
25990938 There was no correlation between TGF-beta1 levels and HBV load, but there is a positive correlation between sFas levels and HBV load.
25982278 IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2
25981594 MTHFR, TGFbeta1, and TNFB polymorphisms are not significantly associated with the risk of osteoporosis in rheumatoid arthritis.
25979247 These results suggest fundamental differences in the dominant pathogenic mechanisms underlying Marfan syndrome , stiff skin syndrome and the acromelic dysplasias, which give rise to TGFbeta dysregulation associated with these diseases.
25977342 High pretreatment serum TGF-beta1 levels were associated with poor prognoses, and increased serum TGF-b1 levels were associated with the disease progression of advanced hepatocellular carcinoma patients.
25973737 The TGF-beta level is higher in HCM patients and associated with a poor prognosis in HCM.
25971746 These findings uncover a plausible mechanism for NF-kappaB-sustained TGF-beta/Smad activation via miR-148a in glioblastoma.
25971370 ncreased TGFB1 expression and decreased TIMP-4 expression correlated with atrial fibrosis and extracellular matrix changes in the atria of rheumatic heart disease patients with atrial fibrillation.
25970154 Study suggests that Rictor/mTORC2 signaling activation mediates TGFbeta1-induced fibroblast activation and contributes to the development of kidney fibrosis.
25966218 TGF-beta1 polymorphism 509 C>T is associated with the risk of hepatocellular carcinoma in HCV-infected patients.
25966122 Data suggest that the transforming growth factor-b1 (TGFB1) rs1800469 polymorphism may be predictive biomarker for the risk of developing brain metastasis in non-small cell lung cancer patients.
25961936 STAT3 acts as a mediator that synergizes TGF-beta and Ras signals
25961925 TGF-beta1 promoted CCL21 expression in lymphatic endothelial cells. CCL21 acted in a paracrine fashion to mediate chemotactic migration of EMT cells toward lymphatic endothelial cells.
25957771 discuss how the actions of TGF-betas and BMPs on cancer stem cells may explain their effects on tumor progression, and try to highlight intricate mechanisms that may link tumor cell differentiation to invasion
25955797 our findings suggest that Ski represses TGF-b-induced EMT and invasion by inhibiting SMAD-dependent signaling in non-small cell lung cancer
25955392 Study shows the stimulatory effect of TGF-beta1 on CTGF expression in human granulosa cells and provide increase the understanding of the normal physiological roles of TGF-beta1 in the ovary.
25954931 TGF-beta 1 increases SERT cellular trafficking in 3D culture of Caco-2 cells.
25952368 Serum TGFB1 was increased in T2DM patients compared to controls, and in patients with diabetic nephropathy, compared to diabetic patients without nephropathy. TGFB1 increased with nephropathy severity.
25943894 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta
25930091 Polymorphisms in TGFB1 gene is related to risk of developing inhibitor, and could contribute to a genetic profile of the individual HA for the risk of inhibitors development to FVIII.
25928368 TGF-beta1 gene C509T polymorphism might be associated with decreased risk of lung adenocarcinoma in Chinese females exposed to cooking oil fumes, but no association was observed TGFBR2 gene G875A polymorphism
25927238 genome-wide expression profiling revealed that, in gingival fibroblasts, (5Z)-7-Oxozeaenol reduces the ability of TGFbeta1 to induce mRNA expression of essentially all TGFbeta1-responsive genes (139/147)
25927212 expression of TGF-beta1 but not TGF-beta2 is significantly increased in papillary thyroid cancer compared to benign thyroid nodules.
25923384 TGF-beta levels are a useful tool for differentiating influenza A (H1N1)pdm09 from other causes of pneumonia progressing to sepsis.
25919050 our study does not support a role for TGF-beta1 and VEGF in causing cancer among transplant recipients treated with CNIs.
25914020 We wished to determine whether profibrotic transforming growth factor beta 1 and activin A and their downstream signaling proteins are increased in chronic rhinosinusitis with nasal polyps and are regulated in epithelial cells by noxious stimuli.
25909813 Results suggest that changes in expression levels of EGF and TGFbeta1 resulting from functional polymorphisms, may contribute to an homeostasis disequilibrium and thus to a higher risk for an earlier disease progression of renal Cell Carcinoma .
25893292 these findings demonstrate that syntenin may act as an important positive regulator of TGF-b signaling by regulating caveolin-1-mediated internalization of TbRI; thus, providing a novel function for syntenin that is linked to cancer progression.
25891879 the findings of the present study suggest that H2O2 contributes to HUVEC apoptosis by inducing Nox4-dependent ROS aggregation and activating the TGF-beta1/Smad2 signaling pathway.
25890309 Suggest that the pro-inflammatory cytokine TWEAK and TGF-beta1 have synergistic effects in EMT and may contribute to chronic airway changes and remodeling.
25888018 low serum levels in the early phase of hantavirus infection is associated with a severe course of disease
25886788 Thrombocytopenia may mediate disease severity in malaria through reduced TGF-beta1-mediated regulation of cytokines associated with severe disease.
25885043 LIF/p21 signaling cascade as a novel tumor suppressive-like pathway in melanoma, acting downstream of TGFbeta to regulate cell cycle arrest and cell death, further highlight new potential therapeutic strategies for the treatment of cutaneous melanoma
25880619 TGF-beta1 and ELF protein are potential and reliable biomarkers for predicting prognosis in HCC patients after hepatic resection.
25873777 miR-21 regulates cell proliferation, apoptosis, and differentiation in orbital fibroblasts from thyroid-associated ophthalmopathy patients, and acts as a mediator in TGF-beta1-induced collagen production.
25872785 knockdown of TMEM45A also inhibited cell adhesion as well as cell invasion. More importantly, suppression of TMEM45A notably downregulated the expression of TGF-b1, TGF-b2, RhoA and ROCK2.
25872451 TGF-beta activates miR-1269 via Sox4, while miR-1269a enhances TGF-beta signalling by targeting Smad7 and HOXD10, hence forming a positive feedback loop.
25871499 Results conclude that TGF-beta1 (rs1800470) may increase the risk of both ESRD and T2D in both populations, but TGF-beta1 (rs1800469) provided risk for only ESRD in the population of Jammu and Kashmir.
25869072 This study shows that TGF-alpha uses common and divergent molecular mediators to regulate E-cadherin expression and cell invasion.
25867300 TNF-beta C804A polymorphism may be associated with an increased risk of myocardial infarction only in Asian populations. [Meta-analysis]
25858321 These results suggested that APE1 controls the organization of actin cytoskeleton through the regulation of TGF-beta1 expression, providing novel insights into the biological significance of APE1.
25858148 The combination of local radiation therapy with TGFbeta neutralization offers a novel individualized strategy for vaccinating patients against their tumors.
25851169 TGFB1 expression is increased in hypoxic bronchial epithelial cells.
25848047 compromised peroxisome activity might play an important role in the molecular pathogenesis of idiopathic pulmonary fibrosis and fibrosis progression, via TGF-beta signaling.
25846512 Platelet activation with a PAR1 agonist triggered TGF-beta secretion, which induced EMT of via the downregulation of miR-200b expression, and activated platelets had a chemotactic effect on colon cancer cells mediated by the upregulation of CXCR4
25835425 This study identified that TGF-beta1 +29C/T associated with Vascular Dementia
25833962 emerging concepts pertaining to TGF-beta and downstream signaling pathways in normal HSC biology, featuring aspects of aging, hematologic disease
25832634 TGF-beta decreases the stability of IL-18-induced IFN-gamma mRNA through the expression of TGF-beta-induced tristetraprolin in KG-1 cells
25830829 The generation and maintenance of sufficient quantities of active TGF-beta to cause tissue fibrosis in multiple organs probably depends on at least two sources-TGF-beta activation by injured epithelial cells and activated fibroblasts.[review]
25826292 Serum levels of TGF-beta and TGF-beta mRNA levels from PBMCs did not differ between young and old women. Age affects TGF-beta signalling in leukocytes by altering the expression levels of its receptors.
25825495 MMP-9 recruitment to the fibroblast cell surface by Lysyl Hydroxylase 3 (LH3) triggers TGF-beta activation and fibroblast differentiation
25824321 it was concluded that TGF-beta1, IGF-I/IGF-IR and VEGF-A overexpression is associated with the presence of aggressive tumors, which exhibit an increased probability of metastasis, a poor response to treatment and reduced survival rate.
25823021 restoring fibulin-3 expression in breast cancer cells inhibited TGF-beta signaling, breast cancer cell EMT, invasion and metastasis in vivo.
25820820 Our results show that NSCLC patients exhibit high VEGF(PLT) and serum TGF-b1 levels, and VEGF(PLT) and TGF-b1 levels correlate with chemotherapy response to GP regimen.
25819880 gene expression in human fetal endothelial cells from gestational diabetes in response to TGF-beta1
25814267 hBMP-2 and hTGF-beta1 can synergistically improve the bone repair process. Our results suggest a potential clinical value of combining hBMP-2 and hTGF-beta1 in repairing bone defects.
25813152 this study suggests that TGF-b1 -509C/T and 869T/C polymorphisms are not significantly associated with risk for developing gliomas but may be relevant prognostic biomarkers in GBM patients
25812349 these results suggest that T869C polymorphism of the TGF-beta1 gene is not associated with SLE disease susceptibility and specific clinical manifestations.
25809486 Transforming Growth Factor-beta (TGF-beta) sialylation is involved in Epithelial to Mesenchymal Transition
25802486 MicroRNA-152 represses VEGF and TGFbeta1 expressions through post-transcriptional inhibition of prorenin receptor in human retinal endothelial cells.
25802474 TGFbeta-509TT genotype was associated with higher plasma viral load.
25802332 Complement component 3 is up-regulated via non-canonical TGF-beta signaling in the retinal pigment epithelium
25789971 These results support the hypothesis that TGF-b(1)-induced autophagy is required for the fibrogenic response in hATMyofbs.
25789970 we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-b-mediated EMT through the Smad signaling cascade.
25778865 results suggest that DACH1 loss of function results in increased cell growth, motility and invasiveness through TGF-beta-mediated EMT, and DACH1 loss of function has important therapeutic implications for targeted therapies of CRC
25776071 DACH1 inhibits aldosterone secretion in human adrenals, and transforming growth factor-beta signaling pathway is activated in DACH1 overexpressed cells and may mediate inhibition of aldosterone secretion in human adrenals.
25773154 This study demonistrated that Conversion to MS was associated with marked variability in the expression of proapoptotic genes that were linked to TGF-B1 gene levels
25771989 TGFB1 gene may be aging-related gene and involved in Osteoporosis.
25767119 p53 can both attenuate and cooperate with the TGF-beta pathway to promote cancer cell malignancy in the same cell type
25753689 This study showed a novel SIRT1 mediated protection against renal and retinal injury in diabetes, regulated through p300, ET-1 and TGF-beta1.
25746720 TGFbeta1 induces apoptosis and epithelial-mesenchymal transition in prostate cancer cells via activation of P38-MAPK and Rac1/Pak1 respectively.
25744234 Polymorphisms in TGF-beta1 and IL-10 may have a significant influence on the development of oral cancer.
25743244 TGFbeta1 and TGFbeta2 appeared to play a significant role in physiological and pathological conditions in the fetus.
25740948 Noncanonical STAT3 activation regulates excess TGF-beta1 and collagen I expression in muscle of stricturing Crohn's disease.
25740392 We conclude that TGF-beta influences the pathophysiology of Marfan syndrome. Thus, TGF-beta may be a therapeutic target for preventing MFS-related complications, including cardiovascular diseases and periodontitis.
25739869 an important attribute of EGF on opposing and reversing Transforming growth factor-beta1 effects, indicating the plasticity of hepatic progenitors
25738867 The results of the current study demonstrated that pro-inflammatory cytokines, including TGF-beta1, IL-1beta and IL-6 exhibited increased expression in human vestibular schwannoma tissue compared with normal vestibular nerve samples
25738611 Findings propose that TGFbeta 868 TT genotype and TT/GG diplotype may confer increased risk of brucellosis in the examined population.
25730867 SIRT1 signaled through a hypoxia-inducible factor-1 alpha (HIF1alpha)-dependent pathway, orchestrating the reciprocal TH1 and T(reg) lineage commitment through DC-derived IL-12 and TGF-beta1.
25728398 In prostate cancer, TGF-Beta binding induces epithelial-mesenchymal transition.
25726184 HtrA1 plays a positive role in human periodontal ligament cells osteogenic differentiation and may regulate this process by TGFB1.
25724945 Three glioblastoma cell lines, SK-MG-1, U251MG and MG178, were tested and CD109 overexpression attenuated TGF-beta1 signaling and enhanced EGF signaling in SK-MG-1, but not in U251MG or MG178.
25724625 High TGFbeta expression promotes pancreatic ductal adenocarcinoma progression.
25722217 our findings suggest that TGF-b1 may inhibit the expression of Pokemon, b-catenin, and E-cadherin. The high expression of TGF-b1 leads to an increase in the phenotype and apical-base polarity of epithelial cells
25721048 single nucleotide polymorphisms show a protective effect under a dominant model of diisocyanate-induced asthma
25714613 review of the immune suppressive functions of transforming growth factor-beta [review]
25710582 CD105 acts as one of the receptors of TGF-beta1 on vascular endothelial cells and induces the angiogenic pathway in oral squamous cell carcinoma.
25710085 In summary, TGF-beta1 and IL-31 were linked to progression from chronic hepatitis B to liver cirrhosis, and correlated well with the severity of disease.
25710054 Genetic analysis of two single nucleotide polymorphisms (SNPs) in exon I of the TGF-beta1 gene did not show significant differences between the occurrence of particular polymorphisms and haplotypes in the populations under study
25710021 In summary, we found that AGE-BSA induced EndMT in HUVECs via upregulating TGF-beta and downregulating Sirt 1, which also negatively regulated TGF-beta in the cell.
25701598 TGF-beta/Smad2/Smad3 signal pathway is involved in glioma tumor cells proliferation and apoptosis.
25684678 Chemoresistance to doxorubicin induces epithelial-mesenchymal transition via upregulation of TGF-beta signaling in HCT116 colon cancer cells.
25684348 These data indicated that TGF-beta inhibited IQGAP1 expression in lung fibroblasts via the NF-kappaB signaling pathway, presenting a potential novel therapeutic target for the treatment of idiopathic pulmonary fibrogenesis .
25681764 The present study demonstrated that TGF-beta synthesized by both cancer cells and stromal cells participates in the oral squamous cell carcinoma - induced bone destruction.
25681335 Data show that in addition to the inhibition of transforming growth factor beta 1 (TGF-beta1) and interleukin 10 (IL-10), bortezomib inhibits mRNA and protein expression of the chemokine receptor CXCR4 in cutaneous T cell lymphoma cells.
25681034 the relationship between serum iron parameters and the levels of TGF-beta, FGF, ET-1, and NO as predictors of chronic liver injury in 54 AHSCT recipients who survived at least a year after transplantation.
25675803 TGF-beta overproduction is observed in vulvar neoplastic processes.
25663491 The morbidity and metastasis of osteosarcoma are relevant to TGF-b1 gene 29 T > C single nucleotide polymorphism.
25662173 We found that the recruited macrophages are polarized to a M2 subtype after renal injury. M2 macrophages released high levels TGFb1 to suppress BMP7 to enhance EMT-induced renal fibrosis.
25661467 this study is the first to demonstrate that HG treatment of A549 human lung epithelial cells promotes tumor cell invasion and increases metastasis-associated protein expression by up-regulating HO-1 expression via ROS or the TGF-b1/PI3K/Akt signaling
25658089 Selective targeting of this SMAD-independent, p38-MAPK/Cav-1-dependent pathway is likely to be effective in the treatment of pathological conditions characterized by TGF-beta signaling and myofibroblast activation.
25658041 Low-intensity pulsed ultrasound could increase transforming growth factor beta1 and activate extracellular signal-regulated kinase pathway
25655430 These results suggest that Wnt5a expressed in PDL tissue plays specific roles in inducing collagen production by PDL cells through TGFbeta1-mediated upregulation of periostin expression.
25645014 Our findings afford new insights into the role played by YB-1 in the TGF-beta1 signaling pathway.
25634187 The TGF-beta1 T869C and TGF-beta1 T29C polymorphisms may be involved in susceptibility to postmenopausal osteoporosis, particular in Asian patients.
25633840 TGFB1 induced miR-155 regulates TP53INP1 expression, epithelial-mesenchymal transition and acquisition of a stem cell phenotype.
25633651 There was no association between TGF-beta gene polymorphisms and juvenile-onset systemic lupus erythematosus in an Iranian cohort.
25618241 both TGF-beta and EGF can induce HLA-I downregulation which is then proven to be associated with epithelial-mesenchymal transition in prostate cancer cells.
25614622 TGFbeta1 stimulated Smad-dependent VEGF-A expression, VEGF receptor-mediated EC migration, and capillary-like tube formation, which were all abolished by either PI3K-C2alpha knockdown or a dynamin inhibitor
25605728 LncRNAs such as lncRNA-HIT ((HOXA transcript induced by TGFbeta) play a pivotal role in EMT and breast cancer progression.
25604047 the elevated serum TGF-beta1 and IL-21 levels could contribute to enhanced Th17 cell differentiation in non-segmental vitiligo.
25603974 association between TGFB1 29 T --> C transition (rs1800470) and IL6 -572G --> C transversion (rs1800796) with developmental dysplasia of the hip (DDH) and TGF-beta1 and IL-6 interaction in DDH pathogenesis.
25596251 Enhanced FHL2 and TGF-beta1 expression is correlated with poor survival in human malignant melanoma
25594618 The TGF-b1 gene rs4803457C/T polymorphism is associated with susceptibility to polycystic ovary syndrome (PCOS), and is the key contributor for the development of PCOS in Chinese Han women.
25592103 This is the first report about the association between ADAMTS4 and TGFb1 serum levels in the progression of atherosclerosis in coronary artery disease (CAD). Furthermore, it is seen that TGFb1 haplotype can cause a genetic susceptibility to CAD in the Turkish population.
25591994 Overexpression of TGFbeta1 promotes pulmonary inflammation, apoptosis and mortality via TGFbetaR2 in the developing mouse lung.
25586740 MicroRNA-10a silencing reverses cisplatin resistance in the A549/cisplatin human lung cancer cell line via the transforming growth factor-beta/Smad2/STAT3/STAT5 pathway
25585026 TGF-beta activates Src in H358 cells largely through a non-canonical redox mechanism.
25580782 TGF-beta and IL-10 genetic variability could contribute to susceptibility to CIU. Additionally, patients with CIU seem to have genotypes leading to high production of TGF-beta and IL-10.
25573346 Role of TGFbeta in regulation of the tumor microenvironment
25569361 Mechanisms involved in cochlear extension of otosclerosis are still unclear, but the implication of TGFbeta1 is supported by the present proteomic data and immunostaining results.
25565012 The lack of correlation of interleukin 10 and TGF-b with immune deficits in situ and in vitro suggests re-evaluating their roles in cancer.
25562163 Our results suggest that TGF-beta1 up-regulates versican expression by suppressing miR-143, and this pathway is important for osteosarcoma cell migration and invasion.
25560488 We herein present a study to highlight the modulation of the MAPK pathway and the abrogation of the MAPK-regulated TGF-beta/Smad signaling in HepG2 cells by three MAPK-specific inhibitors
25550833 Hepatitis B virus transfection could induce TEMT in HK-2 cells, which was mediated by the TGF-beta1/p38 MAPK pathway.
25542095 study suggests a linear negative association between IL-17 and diabetic kidney disease (DKD) and a positive association between TGF-beta and DKD
25540364 Authors demonstrated that hepatitis B virus can upregulate the level of Smad7 and inhibit TGF-beta signaling by downregulating miR-15a.
25535343 Influenza viral neuraminidase enhances the expression of cellular adhesins through the activation of TGF-beta, leading to increased bacterial loading in the lungs.
25531329 DRAK1 was predominantly localized in the cytoplasm and bound to Smad3, thereby interrupting Smad3/Smad4 complex formation, which is the core process for the induction of tumor suppressor genes by TGF-beta1
25531317 Supporting this idea, we identified a downstream target of the TGFb-miR-96 signaling pathway to be AKT1S1 mRNA, whose translated protein is a negative regulator of mTOR kinase.
25526895 MUC1 mediates autocrine TGF-beta signaling by activating the JNK/AP-1 pathway in hepatocellular carcinoma cells.
25524739 miR-424 regulates the myofibroblast differentiation during epithelial-to-mesenchymal transition by potentiating the TGF-beta signaling pathway, likely through Smurf2.
25505291 balance between Smad1/5- and Smad2/3-dependent signaling defines the outcome of the effect of TGF-beta on atherosclerosis where Smad1/5 is responsible for proatherogenic effects
25503443 our findings suggest that there might be a CKI-FoxO/Smad-Bim engine in which Thr32 of FoxO3 is pivotal for TGF-b-induced apoptosis, making it a potential therapeutic target for liver cancer treatment.
25501212 A comprehensive meta-analysis of 4 case-control studies was conducted to explore the association between polymorphisms of Msh homeobox 1 (MSX1) and transforming growth factor-beta1 (TGF-beta1) genes and hypodontia.
25499257 Regulatory T cells and TGF-beta1 are increased in clinically localized renal cell carcinoma
25483191 Identified a novel binding site for c-Jun in the promoter of the Snail1 gene and report that the activation of the TGFbeta-TRAF6-p38 MAPK pathway promotes both c-Jun expression and its activation via p38alpha-dependent phosphorylation of c-Jun at Ser63.
25480330 Thyroid hormones increase airway smooth muscle proliferation and decreases contractile protein expression in the presence of the profibrotic growth factor TGFB1.
25477471 Mechanical stretch upregulated fibronectin and TGF-beta1 expression and activated STAT3 in proximal renal tubular epithelial cells.
25477051 tumoural TGF-beta1 secretion seems to induce nuclear translocation of co-factor FHL2 mediating progressive keratin expression in pilomatricoma.
25476855 we show that activated TGFbeta receptor signaling induces apoptosis of pancreatic carcinoma cells in vitro and in vivo, suggesting that activation of TGFb receptor signaling may prevent development of Pancreatic ductal adenocarcinoma.
25475758 TGF-beta1 gene expression in the peripheral blood may be used as a molecular marker for the diagnosis of HCC.
25471552 adiponectin suppresses Ang II-induced synthesis of ECM in mesangial cells via activation of the AMPK pathway
25471088 placental level not significantly reduced in placenta percreta
25466434 In a healthy adolescent twin cohort, heritability estimates were moderate but significant for transforming growth factor-beta1, 0.57 (95% CI 0.26-0.80).
25464508 TGF-beta1/Smad signaling pathway in human Eca109 ESCC cells might carry similar features as in Kazakh ESCC patients, suggesting that TGF-beta1/Smad signaling pathway might be involved in the regulation of EMT in ethnic Kazakh patients with ESCC
25463116 platelet expressed TGF-beta1 may have a role in acute coronary syndrome
25461397 Data suggest that the tumor necrosis factor-alpha (TNF-alpha)/ transforming growth factor-beta (TGF-beta)/indoleamine 2,3-dioxygenase (IDO) axis may represent a new mechanism contributing to the development of tolerance in IVIg-treated patients.
25458044 There were no significant differences in the distribution of IL-10 and IFN-gamma genotypes between different groups of control and oral precancerous lesions patients but the IL-6, TGF-beta1, and TNF-alpha gene polymorphisms may have a significant association.
25449332 The T29C (rs1800470) polymorphism of the transforming growth factor-beta1 gene is associated with restenosis after coronary stenting.
25433496 Brachyury plays an important role in regulating TGF beta 1-mediated renal epithelial mesenchymal transition and could be an attractive target for progression of renal disease therapies
25428269 It is likely that the Smad-independent ERK1/2 pathway regulates Nox4 expression and may be involved in the TGFB1-induced proliferation of endothelial cells
25422138 Suggest nuclear NF-AT3 and NF-AT4 participates in atrial structural remodeling, and that PICP and TGF-beta1 levels may be sensitive serum biomarkers to estimate atrial structural remodeling with atrial fibrillation.
25422078 our findings in this study suggest that PZH can inhibit metastasis of colorectal cancer cells via modulating TGF-beta1/ZEB/miR-200 signaling network, which might be one of the mechanisms whereby PZH exerts its anticancer function
25421593 the role and mechanism of miR141 in regulating renal fibrosis via the TGFbeta1/miR-141/HIPK2/EMT axis
25420836 The genetic polymorphism TGF-beta1 +869 C/T may be an independent risk factor for CKD after liver transplantation.
25418123 By visually examining the dynamics behavior, structural basis and energetic property of few typical Abl-drug complex cases, a significantly different pattern of non-bonded interactions between the binding of drug ligands to Abl receptor was revealed.
25413124 results suggest that miR-155 might be involved in the pathogenesis of ITP by regulating cytokine profiles, which may be mediated by miR-155 targeting SOCS1.
25412776 Biglycan upregulates BMP-2 and TGF-beta 1 in human aortic valve cells through Toll-like receptors. Both BMP-2 and TGF-beta 1 are required for aortic valve cell pro-osteogenic reprogramming.
25409890 This meta-analysis suggested that transforming growth factor-beta1 rs1800470 polymorphism was a risk factor of lung cancer.
25409617 Taken together, our study provides evidence that TGFbeta receptor signaling-induced EMT may be responsible for the increased PCC invasiveness to enhance its lung metastasis.
25402477 the TGF-beta1 C-509 T polymorphism is involved in the etiology of lone AF and thus may be a marker for genetic susceptibility to lone AF and predicting prognosis after catheter ablation in Chinese populations.
25399301 Increasing expression of TGF-beta1 protein, decreasing expressions of Ghrelin, Neurexin, and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal
25390350 Reduced TGF-beta1 expression in lichen planus may participate in immune dysregulation of the disease.
25384022 increased peritoneal expression of connective tissue growth factor (CCN2), transforming growth factor-beta1, and vascular endothelial growth factor in encapsulating peritoneal sclerosis encapsulating peritoneal sclerosis
25383667 Crystal structures, mutations and peptide-affinity measurements show that alpahVbeta6 binds with high affinity to a RGDLXXL/I motif within the prodomains of TGF-beta1 and TGF-beta3.
25379550 VEGF, PDGF, and TGF-beta1 concentrations in platelets may be associated with prognosis of breast cancer.
25375657 FOSL2 facilitates TGF-beta1-induced migration by interaction with Smad3 in non-small cell lung cancer.FOSL2 positively regulates TGF-beta1 signalling .
25371235 TGF-beta/NKX2.1/PIK3R3 axis is crucial in the TGF-beta-induced inhibition of cell proliferation, and the NKX2.1/PIK3R3 axis might become a target in TGF-beta receptor-repressed lung adenocarcinoma
25370824 The low-cost and easy purification steps allow considering that our proposed preparation of recombinant monomeric TGF-b1 could be employed for in vitro and in vivo experiments as well as for therapeutic intervention.
25369932 HtrA1-mediated LTBP-1 proteolysis prevents its association with fibronectin and the extracellular matrix. Attenuation of TGF-beta signaling caused by a lack of HtrA1-mediated LTBP-1 processing as mechanism underlying CARASIL pathogenesis.
25369910 USP22 may accelerate ovarian cancer cell cycle progression via synergizing with TGFB1 to regulate the TGFB1 downstream cell cycle pathway.
25366936 Higher levels of TGF-Beta1 are associated with more extensive left atrial fibrosis in atrial fibrillation patients.
25366794 Data show that intracellular levels of tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta1 in CD34(+) cells treated with vasoactive intestinal polypeptide (VIP) were increased by 50.70 and 43.46%, respectively.
25363621 TGF-beta suppression followed by Id4 expression results in extensive melanin synthesis and robust histiocyte recruitment following tumorigenesis
25363526 These results are formal proof that PD-1 induction through TCR activation on T cells is partially regulated by endogenous TGF-beta.
25361568 Transforming growth factor-beta induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation.
25358858 an Annexin V assay indicated that TGF-b1 resistance in MT-2Rst cells was not directly involved in the acquisition of resistance to apoptosis that is triggered by CB exposure.
25355597 A model involving crosstalk of the TGFbeta and Wnt signaling pathways.
25354942 Down-regulation let-7 by transforming growth factor-beta1-induced Lin28 upregulates collagen expression in glomerular mesangial cells from diabetic mice.
25354152 The most abundant cytokine present in semen (TGF-beta1) is able to enhance specifically the expression of an important molecule (CD169) involved in the capture and transmission of HIV-1 particles from the mucosal lumen to the submucosal compartment.
25354152 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta
25351340 knockdown of Smad3 significantly reduced TGF-beta1-induced Col.I production. These findings were further evident by the results that overexpression of Smad2 attenuated the expression of Col.I and TIMP-1
25350963 Donor neutrophil activation and transforming growth factor-beta1 modulation induced by donor apheresis procedures.
25344606 ST6GAL1 promotes TGF-beta-dependent epithelial-mesenchymal transition
25339175 Data indicate that influenza A virus H1N1 infection activated alphavbeta6 integrin-dependent transforming growth factor beta (TGFbeta) activity in immortalized bronchial epithelial cells (iHBEC).
25338997 High TGFB1 protein expression is associated with lymph node metastases in non-small cell lung cancers.
25336651 Novel RNA-binding protein P311 binds eIF3b to promote translation of TGF-beta1, TGF-beta2, TGF-beta3.
25333854 Overexpression of TGF-b under the conditions applied here also activated the hypertrophic and osteogenic differentiation processes in the treated cells.
25331952 SHP2 positively regulates TGFbeta1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.
25327287 Moreover, the up-regulation of Axl was induced by TGF-beta1, further activated phosphatidylinositol 3-kinase (PI3K)/Akt and PAK1 translocation, and resulted in greater cell motility, invasion, and chemoresistance in vitro and in vivo
25316285 High TGFbeta expression is associated with breast cancer.
25316133 these data suggest that IL-10 and TGF-beta may modulate FoxP3 expressions at the protein and mRNA levels in respect to their need for peripheral tolerance.
25315297 Data indicate that downregulation of endothelial NADPH oxidase 4 (Nox4) decreases transforming growth factor beta1 (TGFbeta1).
25313057 TGF-beta1 induces nuclear accumulation of RUNX1. TGF-beta1-expressing prostate cancer cells induce hP-MSCs to a myofibroblast differentiation pattern and mediate the reactive stromal response via altered expression of many growth factors and cytokines.
25310970 uPAR has a role in inducing expression of TGFbeta and interleukin-4 in cancer cells to promote tumor-permissive conditioning of macrophages
25308005 this study used immunohistochemical methods to demonstrate the presence of IGF-1, TGF-beta1, and VEGF growth factor receptors in normal, adenomatous, and hyperplastic parathyroid tissue.
25307974 CrkL knockdown markedly suppressed the phosphorylated ERK (p-ERK) as well as the phosphorylated AKT (p-AKT) (p < 0.001) compared with control or TGF-b1 alone.
25301070 Fra-1 induces critical changes in the expression of tgfb1 and Epithelial-to-mesenchymal transition transcription factors through direct binding to the tgfb1, zeb1 and zeb2 genomic regulatory regions.
25298263 rs1800471 polymorphism in TGFB1 gene does not have an impact on the development and progression of non-diabetic chronic kidney disease caused by primary glomerulopathy and chronic interstitial nephritis.
25298166 The present findings suggest that sustained TGF-beta activation in both ICM and DCM contributes to excess myocardial fibrosis.
25287361 FOXQ1 repressed core EMT regulation of the expression of TGF-beta1.
25283440 a promising biomarker in identifying children who are likely to experience food protein-induced enterocolitis syndrome to milk
25282476 Mina: a Th2 response regulator meets TGFbeta.
25278128 AMPK inactivation with NOX4-induced ROS formation and transforming growth factor ss-1 (TGFss-1) signaling activation.
25275602 TGF-beta induced ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion.
25270361 despite the presence of an activated TGF-b1 expression signature in patients' whole blood, the short dosing duration did not translate into significant antitumor effect in the small number of patients investigated in this study.
25268580 CD4+ T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer.
25266958 No difference was found in gene expression of TGF-beta1 in placental samples obtained from small for gestational age pregnancies versus normal pregnancy.
25263239 Elevated TGFbeta expression is associated with acute lymphoblastic leukaemia.
25260899 There is a good correlation between serum TGFb1 and IgG N-glycome and its effect on the outcome of entecavir treatment in patients with chronic hepatitis B.
25249198 review highlights TGF-beta-induced SMAD-dependent signaling and non-SMAD signaling as the major pathways regulated by TRAF4 involved in breast cancer metastasis
25220407 TGF-beta-mediated suppression of ANT2 through NF1/Smad4 complexes contributes to oxidative stress and DNA damage during induction of cellular senescence.
25210118 The results suggest a novel profibrotic function for IL-17A by enhancing the response of hepatic stellate cells to TGF-beta through activation of the JNK pathway.
25207745 The expression levels of collagens type I/III, TGF-beta1, Smad2/3/4/7 and PAI-1 (plasminogen activator inhibitor type 1) in gluteal muscle contraction (GMC) patients were measured.
25205054 highlights a novel function for epithelial cell adhesion molecule in TGF-beta1-induced epithelial-to-mesenchymal transition process
25186014 Human embryonic stem cells prevent T-cell activation by suppressing dendritic cells function via TGF-beta signaling pathway
25183046 TGF-beta induced RBL2 expression through down-regulating miR-93 in renal cancer cells
25175415 This study sheds light on the role of TGF-b in upregulation of miR143 and the role of miR143 in NSCLC progression, indicating that the target of miR143 expression could be further studied as a novel therapeutic strategy for future control of NSCLC.
25164015 Overall, our findings demonstrate a novel mechanism, mediated by elevated expression of the miR424-503 cluster, underlying TGFbeta activation and metastasis of human breast cancer.
25157139 PREP1 modulates the cellular sensitivity to TGF-beta by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation.
25156636 Mutant TGF-beta1 genotypes are significantly associated with MF in Egyptian patients, with the homozygous genotype (T/T) having a stronger association with tumour stage (stage IIb).
25155040 Those carrying mutant allele of rs1800469 showed 73% increased risk of CAD. Haplotype A-T-T-C-C (alleles in order of rs1800468, rs1800469, rs1800470, rs1800471, rs1800472) associated with a 1.49-fold increased risk.
25148935 the present meta-analysis testifies TGF-beta is potently associated with high grade and poor 3 years prognosis of glioma.
25147823 A higher frequency to T/A genotype for IFN-gamma and higher frequency of TT GG and TC GG genotype for TGF-beta polymorphism.
25144187 The p38 signaling pathway mediates the TGF-beta1-induced transdifferentiation of human Tenon fibroblasts to myofibroblasts.
25143398 TGF-beta regulates LARG and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
25142796 tumor cells that expressed high levels of SIX1 could promote lymphangiogenesis and counteract the negative effects of TGFbeta on lymphangiogenesis by increasing the expression of VEGF-C
25138701 these results demonstrate that a cross-talk exists between the TGF-beta1 and SDF-1 pathways in choroid-retinal endothelial cells
25129343 TGF-beta inhibited the expression of NR2F2.
25128193 Vitamin D insufficiency may be a predisposing factor in pemphigus vulgaris with dysregulation of TGFB1/Il-17 ratio.
25120737 Our data demonstrated that mast cell chymase plays an important role in keloid formation through TGF-beta1/Smad signaling pathway.
25119113 This study demonstrates that the C-509T SNP is a significant clinical risk factor for asthma and that the TGF-beta1 cytokine contributes to the progression of the illness.
25118995 Influence of TGFB1 C-509T polymorphism on gastric cancer risk associated with TGFB1 expression in the gastric mucosa.
25117069 High TGF-beta1 mediates estrogen receptor-induced epithelial-to-mesenchymal transition in cancer.
25114173 microRNA 376c (miR-376c) significantly enhanced neural differentiation of hPSCs in a defined condition by suppressing SMAD4
25113270 total serum tsTGF-beta1 is elevated in the entire spectrum of genetic aortic syndromes; however, gradual differences in the increases of tsTGF-beta1 levels may mirror different degrees of alteration of tsTGF-beta1 signaling in different genetic aortic syndromes
25113249 High expression of TGF-beta1 is associated with lymphatic metastasis and vaginal recurrence in cervical adenocarcinoma.
25112155 this meta-analysis does not support the hypothesis that TGF-beta1 gene-509C/T polymorphism is a risk factor for the development of IgA nephropathy
25111595 In patients with schistosomiasis japonica, TGF-beta1 participates not only in the inflammatory process, but also in the fibrotic process in which Hsp47 and CTGF probably play a key role.
25103497 TGFbeta can induce "BRCAness" in certain breast cancers carrying wild-type BRCA genes and enhance the responsiveness to PARP inhibition.
25098666 Signatures related to TNFalpha, IL6, and TGFbeta activation pathways are induced within the first hour of retrodifferentiation of hepatocyte-like cells.
25098449 The study identified that the TGF-beta polymorphism could affect the susceptibility to osteosarcoma by increasing TGF-beta expression and found that the serum TGF-beta level was elevated in osteosarcoma patients, especially in those with metastasis.
25089270 TGF-beta and IGF signaling have roles in regulating adjacent stroma cells in prostate cancer development and progression [review]
25086906 TGF-beta excess induced a hypothalamic RNA stress response, resulting in accelerated mRNA decay of IkappaBalpha, an inhibitor of proinflammatory nuclear factor-kappaB
25081022 HOXB9 promotes epithelial-to-mesenchymal transition via TGF-beta1 pathway in hepatocellular carcinoma cells.
25078120 pIgR down-regulation in chronic obstructive pulmonary disease correlates with severity. Bronchial epithelium in vitro retains aberrant imprinting for pIgR expression. pIgR down-regulation is linked to TGF-beta1-driven reprogramming of bronchial epithelium.
25073432 TGF-beta signaling has a role in regulating fibrotic expression and activity in carpal tunnel syndrome
25068653 Oxidative stress is able to induce conversion of endothelial cells into myofibroblasts via TGF-beta secretion.
25059120 Knockdown of Akt2 using siRNAs or the PI3K inhibitor Ly294002 inhibited TGF-beta1-induced phosphorylation of GSK3beta and expression of Snail1
25056879 data suggest that in epithelial cells stimulated with TGF-beta, early signaling is a mixture of both pro- and antiproliferative signals, whereas later signaling primarily inhibits proliferation.
25056447 Studies indicate key role of inhibitory cytokines IL-10 and TGF-beta produced by regulatory T (Treg) cells for the generation of immune tolerance to allergens.
25052241 Latent TGFB1 is compartmentalized between blood and seminal plasma of HIV-positive men and its activation in semen is negatively correlated with viral load and immune activation
25051016 Results suggest that ezrin is required for epithelial mesenchymal transition(EMT)-induced by TGF-beta1. The interaction of ezrin and PODXL may be important in regulating TGF-beta1-induced EMT.
25041364 miR-199a targeted the sequence within the 3'UTR of the N-cadherin mRNA and suppressed the TGF-beta1-induced increase in the protein level of N-cadherin in a manner independent of SNAI1.
25035980 CGRP-induced cAMP/PKA activation suppresses activation of MAPK induced by TGFbeta1
25035928 data suggest that overexpression of TGF-beta1 positively enhances the proliferation and chondrogenic potential of hSD-MSCs
25035170 study identified 346 proteins involved in renal carcinogenesis and confirmed presence of a metabolic shift in aggressive tumors; TGFBI was overexpressed in tumors with high SSIGN(stage, size, grade and necrosis) scores and significantly associated with oncologic outcomes
25019584 genetic association studies in population of women in Iran: Data suggest that serum levels of TGFB1 and an SNP in the promoter for Foxp3 (forkhead box P3; rs3761548) are not associated with recurrent spontaneous abortion in population studied.
25001665 UV radiation emitted by the solar simulator was able to stimulate the cells from extracellular matrix in in vitro culture to TGF-beta production, MMP-2 and MMP-9 expressions and their mRNAs.
24995325 Serum IL-17 and IL-23 levels demonstrate no association with type 1 and type 2 diabetes, but, in line with previous studies, TGF-beta levels were lower in type 1 diabetic patients
24992582 The TGFB1-miR-21-reactive oxygen species pathway of bystander cells has an important mediating role in radiation-induced bystander effects in H1299 cells.
24987792 MCs may play an important role in airway remodeling in asthma as a direct source of PAI-1 and by activating bronchial ECs to produce further PAI-1 via a TGF-beta1-mediated activation pathway.
24978189 TGF-beta1 signaling inhibits beta2-agonist-mediated CFTR activation and subsequent increased epithelial permeability, potentially limiting the ability of beta2-agonists to facilitate paracellular transport in disease states unless TGF-beta1 signaling is inhibited.
24973511 The moderate overexpression of TGF-beta1 and TbetaRII mRNA in PTC tissues.
24966004 This study provided strong evidence supporting the disorganized vascular structures and dysregulation of related molecules in sporadic VMs.
24962218 The TGFbeta1 induced EDA+ production was dependent on PI3 kinase-AKT signalling and SRp40 expression
24958810 genetic association study in population in India: Data suggest that (in addition to mutations in cystic fibrosis transmembrane conductance regulator) an SNP in TGFB1 (rs1800470) is associated with congenital absence of vas deferens in population studied.
24953558 An inverse relationship for WISP1 and miR-92a was found in a TGF-beta1 dependent lung fibrosis model in vivo
24946721 Data indicate that concordant transforming growth factor-beta1 (TGFbeta-1) positive and EH-domain containing 1 (EHD1) negative as a strong favorable prognosis factor in non-small cell lung cancer (NSCLC).
24944016 Together, these results suggest that p44/WDR77 expression causes the non-sensitivity of proliferating cells to TGFbeta signaling, thereby contributing to cellular proliferation during lung tumorigenesis.
24937189 The aim of this study was to investigate whether HPSE can modulate the expression and the effects of TGF-beta in tubular cells.
24935594 these results suggest that TGF-beta1 plays an important role in colorectal cancer development.
24935472 Studies indicate that as an inhibitor of transforming growth factor beta (TGF-beta) signaling, SMAD family member 7 (SMAD7) is overexpressed in numerous cancer types and its abundance is positively correlated to the malignancy.
24934480 Platelet-rich plasma induces mixed osteogenic/osteoclastogenic phenotype in osteosarcoma SaOS-2 cells: role of TGF-beta
24927163 Study demonstrated that versican, TGFbeta1, Col7A1 and ITGbeta3 are up-regulated in isolated Cancer stem cells.
24912879 Data indicate that dachshund family transcription factor 1 (DACH1) suppresses gastric cancer cell proliferation, invasion and metastasis by inhibiting transforming growth factor beta (TGF-beta) signalling pathways both in vitro and in vivo.
24910449 Studies indicate that transforming growth factor beta (TGF-beta) family signaling plays key roles in regulating pluripotency and differentiation of embryonic stem (ES) cells.
24907118 Report crosstalk between TGF-beta1 and CXCR3 signaling in the regulation of urethral fibrosis.
24901250 The TGF-beta/Smad signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation.
24892648 Tumor-associated macrophages promote tumor stem cell-like properties via TGF-beta1-induced epithelial-mesenchymal transformation in hepatocellular carcinoma.
24891760 TGFB1 has roles in early and late breast cancer in apoptosis, tumor progression, higher cell motility, cancer invasiveness, and metastasis [review]
24890385 Tumor-suppressive effects of TGF-beta persist in some breast cancer patients at the time of surgery and affect clinical outcome.
24886277 possibly plays a role in the pathogenesis of schistosomiasis-associated pulmonary arterial hypertension
24886104 TGF-beta1 may impair glucocorticoid action through a novel non-canonical signalling mechanism.
24878758 Significant diurnal variations in platelet counts and TGF-b1 and PDGF-BB levels were not observed in platelet-rich plasma.
24861919 Id-1 and TGF-beta1 played important roles in the progression of gastric cancer, in which Id-1 might act as a downstream mediator of TGF-beta1 signaling through a regulatory mechanism involving N-cadherin and beta-catenin.
24844469 alpha1A-adrenergic receptors are stably expressed and stimulate cell migration and TGF-beta1, IGF-1, hyaluronan and PIP production in human skin fibroblasts.
24840097 In conclusion, the TT genotype of TGFbeta1 T869C was associated with RA risk in the overall population and Asians.
24835503 a previously unrecognized mechanism for ESM cell contraction that depends on TGF-beta1, its receptors, and PLN.
24830724 The TGFbeta-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors.
24828686 They also antagonized the TGF-beta1 induced up-regulation of CTGF and transgelin.
24825461 Our results support the earlier findings of A2BP1 and TGFB1 being osteoarthritis susceptibility genes and provide evidence of a possible gene-gene interaction in the genetic influence on hand OA predisposition.
24823830 Meta-analysis indicates that the TGF-beta 1 869 T>C polymorphism is associated with the risk of preeclampsia.
24821840 Tenascin-X promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.
24819318 EGR1, SP1 and KLF6 could be responsible for TGFB1 basal expression, KLF6 appearing specific to atherosclerotic lesions.
24819026 No significant differences were detected between the CML group and healthy controls with respect to the distributions and numbers of genotypes and alleles in TNF-alpha, TGF-beta1, IL-10, and IFN-gamma
24816397 Data indicate that HCV E2 glycoprotein interacts with cellular AIMP1/p43 protein and promotes cell surface expression of membrane glycoproteins gp96 and transforming growth factor beta TGF-beta signaling.
24804215 Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.
24802670 PAX6 activates miR-135b to inhibit TGF-b and BMP signaling thereby differentiating hESC toward a neural phenotype.
24801815 This study suggests that reduced MIR130A is involved in ITP via targeting of TGFB1 and IL18 expression.
24796928 The aim of this study was to determine whether TGF-beta induces a "Warburg-like" effect in peritoneal endometriosis.
24790080 report identifies PARP1 as a novel modulator of two UHRF1-regulated heterochromatin-associated events: the accumulation of H4K20me3 and the clearance of DNMT1
24782191 Dysregulation of transforming growth factor beta signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy in oligoarticular juvenile idiopathic arthritis.
24780821 HGF and TGF-beta are critical regulators for both tumor-stroma interaction and tumor invasion.
24772507 enhanced TGF-beta1 expression in nonparenchymal liver cells in autoimmune hepatitis and primary biliary cirrhosis with liver cirrhosis confirms the role of this cytokine in development of fibrosis in autoimmune liver diseases.
24771267 serum levels of TGF-beta1 have diagnostic, predictive, and possible prognostic roles in melanoma patients.
24771066 These results suggest that ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-b1/ALK5/Smad2 pathway, and thus plays a crucial role in vascular endothelial cells.
24768363 TGFB1 signaling is differentially regulated in aneurysmal tissue and may play a causative role in the development of abdominal aortic aneurysms.
24768205 long noncoding RNA activated by TGF-beta was upregulated in hepatocellular carcinoma metastases and associated with poor prognosis.
24768095 demonstrated a key role of IL-1beta and TGF-beta in the disappearance of occludin at cellular border in placentas with chorioamnionitis
24767210 HIF1A may regulate some of the gene expression and biological behavior of TGFbeta1 pathway-expressing melanoma cells, in part via alterations in miR-210, miR-218, miR-224, and miR-452
24763824 We identify that TGFb1-related miR-143, miR-145, miR-146a, and miR-199a may have a key role in the development of prostate cancer metastasis and the restoration of their expression may be a promising therapeutic strategy for PC treatment.
24758905 Human TGFb1 contribute to Staphylococcus epidermidis biofilm formation in lung cancer.
24758301 Data indicate that advanced glycation end product 3 (AGE3) increased the expression of TGF-beta mRNA and protein stromal ST2 cells and human mesenchymal stem cells.
24756761 Moreover, the upregulated miR-21 by nicotine promoted EMT transforming growth factor beta (TGF-beta) dependently
24742542 genetic polymorphism is associated with Graves' disease in Turkey
24740564 Serum TGFB1 level is elevated in breast cancer patients and has a favorable prognostic value.
24739390 Analysis of the mechanism regulating this interplay identified a new transcriptional complex including GLI1 and the TGFbeta-regulated transcription factor, SMAD4.
24738292 cagocel lead to an increase of IL-4 (p > 0.05), IL-2, IFN-gamma (p < 0.05) and decrease of TGF-beta and IL-12 (p < 0.05). At the same time basic therapy facilitated a significant increase of IL-5 and decrease of IL-6, IL-12, IFN-gamma.
24737521 The CC genotype and the C allele of TGF-beta1 might be a specific risk factor of ACS in the Chinese Han population.
24735795 Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta when cultured in the presence of fibronectin and unpolymerized or polymerized collagen.
24732132 Plasma TGF-beta1 and TGF-beta1 secretion in dermal fibroblast cell lines were increased in subjects with fibromuscular dysplasia compared to age- and gender-matched controls.
24728978 NEDD9 regulates epithelial-mesenchmal transition and cell invasion in prostate cancer cells induced by TGF-beta.
24727589 We found that seprase is transcriptionally up-regulated in invasive melanoma cells via the canonical TGF-beta signaling pathway, supporting the roles of both TGF-beta and seprase in tumor invasion and metastasis.
24721794 Demonstrate that Mkk4 is a negative regulator of the TGF-beta1 signaling associated with atrial remodeling and arrhythmogenesis with age.
24719252 The data suggest that the balance of TGFA and TGFbeta(1) expression, and to a lesser extend TGFA alone, in the normal-appearing rectal mucosa may be directly associated with risk for incident, sporadic colorectal neoplasms.
24711618 results suggest that TGF-beta1 may be a key promigratory factor in recruiting MSCs to the airways
24711139 The results suggest that the expression level of TGF-b1 and a-SMA in stromal fibroblasts may have prognostic significance in patients with clinical stage I-IIIA NSCLC after curative resection
24710116 REVIEW: TGF-beta1 gene polymorphism in association with diabetic retinopathy susceptibility
24709321 TGFbeta signaling regulates miR373, which promotes mesendoderm differentiation in human embryonic stem cells
24705725 The mechanism for MMP-9 regulation of collagen gel contraction is mediated through the generation of active TGF-B1.
24705444 Recipient TGFB1 high producer haplotypes were significantly associated with an increased risk for acute rejection in solid organ transplant recipients, particularly patients receiving cardiac allograft.
24704995 it could be possible that TGF-beta1 plays a role in the formation of fibrous capsule in ChRCCs.
24686421 CD34+ cells cultured under hypoxic conditions secreted high levels of latent TGFbeta.
24684802 Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 by regulating its stability and regulates the TGFbeta1-induced E-cadherin down-regulation.
24684589 inducing eosinophils into the outer membrane and resulting in elevation of TGF-beta with the Smad pathway activated by TGF-beta
24680479 It is apparent that patients with periodontitis display altered immune responses. Among the inflammatory mediators analyzed in this study, TGF-beta1 levels were consistently elevated in patients.
24669775 mitotic asynchrony is not only associated with but is also causative of TGF-beta1 secretion in airway epithelium
24668348 Human tumor-infiltrating CD4+CD69+ T cells suppress T cell proliferation via membarene -bound TGF-beta-1.
24662327 Id-1, a protein repressed by miR-29b, facilitates TGFbeta1-induced EMT in human ovarian cancer cells and represents a promising therapeutic target for treating ovarian cancer.
24659787 Data indicate that transforming growth factor-beta (TGF-beta) is not only produced by T cells, but also regulates T cell responses.
24659786 Studies indicate that transforming growth factor-beta (TGF-beta) is not only produced by T cells, but also regulates T cell responses.
24655966 results suggest that the relationship between plasma TGF-beta1 expression and the development of allograft nephropathy remains uncertain
24648515 Nuclear TAZ/YAP also cooperate with TGFbeta signaling to promote phenotypic and transcriptional changes in nontumorigenic cells to overcome TGFbeta-repressive effects.
24643220 Low expression of TGF-beta1 protein is associated with a poor prognosis for patients with stage III rectal cancers
24643032 Our findings strengthen the association of TGFB1 (rs1800472) with otosclerosis.
24642488 The T869C polymorphism of TGF-beta1 may be associated with radiation pneumonia risk only in Caucasians; there may be no association between C509T and G915C polymorphism and radiation pneumonia risk. (Meta-analysis)
24638085 breast cancer cell was deficient in Dab2 expression and related receptor endocytosis-mediated TGF-beta depletion, which may contribute to the accumulation of TGF-beta in tumor microenvironment and the induction of immune tolerance.
24636138 Smad3 and phospho-Smad3 protein levels gradually decreased while TGF-beta1 mRNA level gradually decreased and the Smad7 mRNA level gradually increased from normal anterior pituitaries, noninvasive NFPAs, to invasive NFPAs.
24629090 This review will discuss the role of PPP1 in the regulation of several TGF-beta signalling members and how the subversion of this pathway is related to prostate cancer development.
24623035 High serum levels of transforming growth factor-beta1 is associated with low response to therapy in esophageal squamous cell carcinoma
24622514 Antagonism of TGF-beta signaling by TGF-beta neutralizing antibody, short hairpin RNA-mediated Smad3 or Smad2 knockdown, Smad3 haploinsufficiency, or endothelial cell-specific Smad2 deletion resulted in decreased endothelial-to-mesenchymal transition.
24622053 the effects of IL1beta, TGFbeta1, and IL1beta in combination with TGFbeta1 on myofibroblast formation
24619148 This study demonstrated that there is a significant contribution of -509C/T and 869T/C (codon 10) polymorphisms of tgf-beta1 in pediatric migraineurs.
24613410 These studies highlight the role of free radicals in p53 activation and subsequent pro-fibrotic reprogramming by TGF-beta1 via the SMAD3-p53 transcriptional axis.
24613385 Reveal an opposite role of Hsp70 and Hsp90 in regulating TGF-beta signaling by implicating CHIP-mediated Smad3 ubiquitination and degradation. This study provides a new insight into understanding the regulation of the TGF-beta signaling by chaperones.
24610082 High transforming growth factor-beta1 expression is associated with metastasis in breast cancer.
24599399 TGF-beta signaling modifies the severity of recessive dystrophic epidermolysis bullosa disease in monozygotic twins.
24597398 Results indicate that inflammatory signaling through LTB4 may be more closely linked to calcification and aortic stenosis than signaling through TGF-beta1 and microparticles.
24597264 expression of the antioxidase glutathione peroxidase 1 in pelvic support structure of pelvic organ prolapse women was decreased, which resulted in the antioxidation reduced and may induce down-regulation of transforming growth factor-beta1-CTGF pathway
24586048 TGF-beta-inducible microRNA-183 silences tumor-associated natural killer cells.
24583628 We identified different markers that correlated with increased risk of organ-specific graft vs host disease (for example, FCGR2A SNP for oral GVHD, and FAS and TGFB1 SNP for lung GVHD).
24583153 Patients with lipodystrophy had higher expression of TNF-alpha and caspase-3 and lower TGF-beta, compared to the control group.
24582746 HOXB9 overexpression increased the tumorigenicity of glioma cells in vivo. Moreover, the activation of transforming growth factor-beta1 contributed to HOXB9-induced oncogenic activities.
24579958 Genetic polymorphism in TGFB1 is not associated with acute rejection in renal transplantation.
24578639 compartment of myeloid stroma cells, such as tumor-associated macrophages, neutrophils, and dendritic and mast cells, which are potently regulated by TGF-beta and produce large amounts of MMPs.
24564406 T869C, C509T, G915C polymorphisms not associated with IgA nephropathy risk [review]
24554662 Authors show that human herpesvirus 4 EBNA2 represses BIK in B-cell lymphoma-derived cell lines and that this host-virus interaction can inhibit the proapoptotic effect of transforming growth factor beta1.
24553827 TGF-b1 suppressed Cdo1 gene transcription through the MEK/ERK pathway.
24551192 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta
24550394 Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein.
24533640 Serum TGF-beta1 and SMAD3 levels are closely associated with coronary artery disease, and may become useful biomarkers for diagnosis and risk stratification.
24530353 Respiratory exposure to multi-walled carbon nanotubes induced length dependent pulmonary fibrosis and epithelial-derived fibroblasts via TGF-beta1/Smad2 pathway.
24520074 Dll4/Notch signaling in tumor cells magnified TGF-beta-induced pSMAD2/3 signaling and was required to sustain TGF-beta-induced tumor cell growth
24515257 Transforming growth factor-beta1 downregulates vascular endothelial growth factor-D expression in human lung fibroblasts via the Jun NH2-terminal kinase signaling pathway
24511106 Although TGF-beta initially inhibits epithelial growth, it appears to promote the progression of advanced tumors.
24508081 Studies suggest that the unmasking of receptor binding epitopes of transforming growth factor beta (TGFbeta) is only one (and in some cases a non-essential) function of precursor processing.
24503768 Infusion of IL-10/TGF-beta1 cotransfected dendritic cells induces alloantigen-specific T cell hyporesponsiveness, inhibits antigen-specific immunological responses to liver allografts, prolongs liver allograft survival, and enhances the immune tolerance.
24503536 Par-4 is a target of TGF-beta signaling and acts as an important factor during TGF-beta-induced epithelial-to-mesenchymal transition.
24503509 Studies indicate that transforming growth factor beta (TGF-beta) superfamily members regulate early embryonic development.
24501422 These results suggest that miR-218 regulates the ability of TGFbeta to induce myofibroblast differentiation in fibroblasts via cezanne/FAK.
24496679 Data show that TGF-beta1 precursor was an independent positive prognostic factor for distant disease-free survival in patients received adjuvant chemotherapy.
24495560 Subjects with type 2 diabetes and LDL phenotype B have higher levels of TGF-Beta1.
24494202 Nox4 NADPH oxidase may be an important downstream effector in mediating TGF-beta-induced fibrosis, while NADPH oxidase-dependent redox signaling may in turn regulate TGF-beta/Smad signaling in a feed-forward manner. Review.
24489856 Human induced pluripotent stem cells absolutely required TGFB1 to maintain pluripotency.
24486560 This meta-analysis and systematic review suggested that donor TGFB1 +869T/C polymorphism was significantly associated with AR of solid organ transplant recipients
24486052 Show a dual direct and indirect involvement of TGFB1, cytokines and eosinophil-derived mediators in the fibrosis and dysmotility that characterize esinophilic esophagitis.
24481402 High TGFBI levels were associated with longer overall survival (OS, P<0.001) and progression-free survival (PFS, P<0.001) in SCC patients who received adjuvant platinium-based chemotherapy.
24463810 These findings suggest that IL-10 and TGF-beta1 genotypes are related to the age of acute otitis media onset, multiple acute otitis media episodes and insertion of tympanostomy tubes.
24462401 Helicobacter pylori vacA increase markedly gastric mucosal TGF-beta1 mRNA expression in gastritis patients.
24457954 Nox4 and reactive oxygen species have pivotal roles in mediating TGF-beta-induced endothelial apoptosis.
24448750 Urothelial bladder carcinoma displayed elevated expression for cyclin D1, VEGFA and TGFbeta1.
24447834 Data show down-regulation of cyclic adenosine monophosphate (cAMP) was the secondary signalling after H4 receptor activation, which in turn resulting in inactivation of transforming growth factor-beta1(TGF-beta1) pathway.
24445397 TGF-beta upregulates miR-182 expression to promote gallbladder cancer metastasis by targeting CADM1.
24443223 TGFb1 rs1800469 C>T polymorphism was significantly associated with decreased risk of conotruncal heart defects. TGFbetaR2 and VEGF polymorphisms may not play a role in the susceptibility of conotruncal heart defects.
24443024 The increased TGF-beta signaling in Marfan Syndrome and Loeys-Dietz Syndrome implies a relationship between the normal development of connective tissue and the cardiovascular system. (Review)
24434151 Investigated the effect of Id1 on TGF-beta-induced collagen expression in dermal fibroblasts. When Id1-b isoform was overexpressed, TGF-beta-induced collagen expression was markedly inhibited.
24432317 Levels of TGF-beta1 and corresponding mRNA are elevated during the active stage of IBD but not during the remission. Longitudinal assessment of this cytokine in a single patient may help to monitor the clinical course of inflammatory bowel diseases .
24428217 TT genotype of TGF-beta1 T869C in the overall population was associated with diabetic nephropathy risk
24427302 High expression of IGFBP7 in fibroblasts induced by colorectal cancer cells is co-regulated by TGF-beta and Wnt signaling in a Smad2/3-Dvl2/3-dependent manner.
24425107 no association between the studied SNPs of TGFbeta1 and breast cancer among Iranian women.
24424023 TGFB1-mediated induction of the short MKL1 isoform initiates progression to later stages of differentiation towards a stationary myofibroblast.
24418364 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta
24418088 Studied the expression of E-cadherin, N-cadherin, TGF-beta1 and Twist protein and investigate its significance in the occurrence and development of prostate cancer.
24416431 A quantitative parameter for antigen-induced cytokine-mediated regulation (R(AC) of HIV-specific effector T cell activation by functional antibody-blockade of IL-10 and transforming growth factor-beta, is reported.
24402195 Compared to controls, plasma levels of TGF-beta1 and TGF-beta2 were significantly lower in patients with recurrent VTE (p < 0.05), whereas no difference was found for TGF-beta3.
24394555 miR-181a promotes TGF-beta-mediated epithelial-to-mesenchymal transition via repression of Smad7.
24385212 ALCAM expression and shedding is elevated in response to TGF-beta signaling.
24382352 FOXM1 promotes breast cancer metastasis by increasing nuclear retention of SMAD3; there is crosstalk between FOXM1 and TGF-beta/SMAD3 pathways
24378993 Smad3 plays an important role in the TGF-beta/Smad3 signaling pathway.
24378341 PDGF positively modulates the TGF-beta-induced osteogenic differentiation of hMSCs through synergistic crosstalk between MEK- and PI3K/Akt-mediated signaling.
24376712 role of Id2-TGFbeta crosstalk in reversible adaptive plasticity in neuroblastoma
24349426 results do not support the role of the TGFB1 rs1800469 functional gene variant in the development of AF in the Chinese Han population.
24347181 An impairment of the transforming growth factor-beta1 (TGF-beta1) signaling pathway has been demonstrated to be specific to the AD brain.
24347165 Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-beta signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.
24343358 study shows that Id2, Id3 and Id4 are each able to overcome TGF-beta dependence, and establish a role for Ids as key mediators of TGF-beta melanomagenesis
24339725 Keratoconic corneas are distinguished with high expression of TGF-beta1 and DUSP1.
24335017 Identify a novel mechanism of interaction between TGF-beta1 and miR-21 in the regulation of FasL protein, which is involved in keloid formation.
24330808 These data indicate that reduced bioavailability of TGF-beta1 in the serum of Huntington disease subjects.
24324757 The differential and synergistic effect of retinoic acid and TGF-beta on switching of different B cell subpopulations to IgA, is reported.
24324363 expression of TGF-beta1 and FGFR4 could make synergy on the occurrence and progression of HCC, and may be used as prognosis indicators for HCC patients
24324267 ZNF451 acts as a transcriptional corepressor for Smad3/4 and negatively regulates TGF-beta signaling.
24324260 c-Met and CD44v6 receptors have roles in autocrine TGF-beta1 signaling in interstitial lung disease
24316888 The results of this study identify a unique microglial signature that is dependent on TGF-beta signaling and provide insights into microglial biology and the possibility of targeting microglia for the treatment of CNS disease.
24315820 TGF-beta1 TT genotype may determine the development of osteoporosis.
24313289 Our results suggest that IL-2 (-330T/G), IL-4 (-589 C/T) and TGF-beta1 (+869T/C) gene polymorphisms may be associated with TB susceptibility.
24311892 The expression of TGFB1 and TGFB2 increase significantly in benign prostatic hyperplasia treated with 5-alpha reductase inhibitor.
24310606 Immunochemistry and clinicopathological results showed that the expression of NT5E and FcGBP in gallbladder adenocarcinoma is an independent marker for evaluation of the disease progression, clinical biological behaviors and prognosis.
24305876 FGFR1, WNT, and TGF-beta have roles in signaling of reactive stroma in aggressive prostate adenocarcinomas
24305026 In chronic subdural hematomas, the expression of TGF-beta was slightly increased in the dura and markedly up-regulated in the outer membrane.
24294365 Suggest role for TGFB1 regulation of epithelial-mesenchymal transition proteins in synovial sarcomas.
24292682 a high level of miR-106b induced by TGF-beta determines the tumor-promoting effects of TGF-beta in breast cancer
24290926 Impact of TGF-b on breast cancer
24286426 Both heterozygotes of C509T polymorphism and T allele of T869C polymorphism in TGFbeta1 were associated with the risk of IgAN in Caucasians, but not in Asians
24283210 IL-22 contributes to TGF-beta1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells.
24271554 TGF-B1 509T/C, P-selectin-2441A/G and MCP-1 2518A/G had combined effects on the formation of crescents in IgAN patients.
24269701 genetic polymorphisms may be risk factor for asthma susceptibility
24259667 Smad7 enhanced ubiquitylation of Myc through direct interaction with Myc and recruitment of Skp2. Ablation of Smad7 resulted in less sensitivity to the growth inhibitory effect of TGF-beta by inducing stable Myc expression.
24258001 Treatment with GM-CSF increased the expression of vimentin and ZEB1, similar to TGF-b1 treatment, and decreased the expression of E-cadherin.
24257415 TGF-beta interfered with NFAT3 translocation, and subsequently with miR-140 expression
24254308 This meta-analysis suggested that the T allele of TGF-beta1 509C/T polymorphism is probably the susceptibility factor for gastric cancer
24245787 The effect of TGF-beta1 and BMP-4 on bone marrow-derived stem cell morphology on a novel bioabsorbable nanocomposite material.
24240172 IKKgamma facilitates RhoA activation via a guanine nucletotide exchange factor, which in turn activates ROCK to phosphorylate IKKbeta, leading to NF-kappaB activation that induced the chemokine expression and cell migration upon TGF-beta1.
24236690 The ratio of TGF-beta1/IL-17 is associated with disease progression in patients with HBV-liver cirrhosis.
24222720 serum TGF- beta 1 concentrations are one of the factors that may have an impact on the progression of vascular complications in children and adolescents with T1DM
24209892 The activation of TGF-beta and Notch signaling pathways may be involved in the bacteria-mediated proliferation of aortic smooth muscle cells .
24204837 miR-1207-5p, a PVT1-derived microRNA, is abundantly expressed in kidney cells, and is upregulated by glucose and TGF-beta1.
24203464 Co-stimulation with EGF and TGFB1 results in rapid and robust ERK1/2 activation and induces persistent high expression of Snail protein.
24195511 did not find any association between 5557G>A polymorphism in the ATM gene or single TGFB1 polymorphisms and late toxicity
24192939 TGFbeta induced PLOD2/LH2 expression in human synovial osteoarthritic fibroblasts through ALK5 signaling.
24190591 SLP-2 was upregulated by TGF-beta1, indicating a possible role of SLP-2 in Papillary thyroid cancer tumorigenesis.
24186850 The usefulness of serum Transforming growth factor-beta1 (TGF-beta1), Glypican-3 (GPC3), and Golgi protein-73 (GP73) mRNAs as early biomarkers in HCC Egyptian patients, was investigated.
24185116 Higher TGF-beta with lower CD124 and TSLP, but no difference in PAR-2 expression in bronchial biopsy of bronchial asthma patients in comparison with COPD patients.
24183998 The data indicate that osteosarcoma cells secrete TGF-beta to maintain the stemness of MSCs and promote the production of pro-tumor cytokines by these cells.
24170657 moderate risk of bias show a statistically significant association with the ACE gene, AGT gene, OTSC2, RELN gene, TGFB1 gene, 11q13.1, OTSC2, OTSC5, OTSC8, and OTSC10. [Review]
24162774 Data indicate that signaling by HIV-1 gp120 through integrin alpha4beta7 resulted in increased expression of the immunosuppressive cytokine TGF-beta1 and FcRL4.
24162774 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta
24161121 genetic polymorphism is associated with progression of hepatitis B to hepartocellular carcinoma in India
24157709 The REGgamma-proteasome pathway is regulated diffentially by p53/TGF-beta signaling and mutant p53 in cancer cells.
24155219 transforming growth factor beta produced by fibroblasts increased spheroid formation and expression levels of cancer stem cell markers in cancer stem cells, a process inhibited by inhibitors of TGF-beta signaling.
24153451 Both TGF-beta1 and TNF-alpha modulate clinical severity and airflow limitation in an additive manner in COPD.
24146803 c.29C>T and c.74G>C polymorphisms in the TGF-beta1 gene significantly affect breast cancer risk, which correlates with elevated TGF-beta1 level in the patients.
24145170 FOXO1 coordinates the response of keratinocytes to wounding through up-regulation of TGF-beta1 and other factors needed for keratinocyte migration and protection against oxidative stress, which together promote migration and decrease apoptosis.
24144036 Studied expression of TGF-beta1, Smad3 and IL-6 in 50 cases with atrial fibrillation (AF) and 30 normal cases. The TGF-beta1, Smad3 and IL-6 mRNA and protein expression levels in patients with AF were significantly higher than that in the control.
24133214 We conclude that WASp function restricts TGF-b1 secretion in a Cdc42- and Src family kinase-dependent manner and independently of actin assembly
24130819 no statistical evidence for an association between SNPs in TGFB1 and risk of late radiation-induced injury of normal tissue.
24129565 TGF-b1 is capable of eliciting anti-inflammatory effects by inhibiting NF-kappaB specifically in the intestinal epithelium as well as by decreasing systemic IL-6 and IFN levels
24129188 under hypoxic conditions, POSTN regulates PHD2 expression and HIF-1alpha levels by modulating TGF-beta1 signaling, leading to decreased apoptosis.
24126595 TGF-beta1 resulted in epithelial-mesenchymal transition in bronchial epithelial cells, characterized by decrease in E-cadherin expression and the increase in vimentin and alpha-smooth muscle actin expression, and the associated increase in Snail expression.
24123012 Nox4-derived reactive oxygen species, at least in part, transmit TGF-beta-triggered epithelial-mesenchymal transition signals through PTP1B in pancreatic cancer.
24120850 IGFBP-5 is important in maintaining epithelial-mesenchymal boundaries and thus may limit metastasis and fibrosis by inducing an orderly repair mechanism, very distinct from the fibrotic disruption induced by TGFbeta1.
24118261 in the skin affected by bleomycin-induced fibrosis, increased TGF-beta1 expression suppresses adipogenesis and promotes adipocyte fibrosis
24113459 Brucella abortus induces collagen deposition and MMP-9 down-modulation in hepatic stellate cells via TGF-beta1 production.
24106276 Snail mediates TGF-beta1-induced down-regulation of VE-cadherin, which subsequently contributed to TGF-beta1-decreased trophoblast cell invasion.
24100613 TGF-beta induces miR10a/10b expression and TGF-beta-induced miR10a/10b expression promotes cell migration through the suppression of PTEN.
24098582 TRPV1 potentiates TGFbeta-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop.
24094956 Gene transcripts for known upstream and downstream TGF-beta mediators are differentially expressed in liver specimens from children with biliary atresia and a fibrogenic gene signature.
24088962 Renal fibrosis resulting from excessive accumulation of extracellular matrix mainly driven by TGF-beta1 is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b.
24084832 The present study developed an efficient strategy for differentiating human hair follicle stem cells into contractile smooth muscle cells by stimulation with TGF-beta1 and PDGF-BB.
24083683 present data suggest that TGF-beta1 may be important in the pathogenesis and progression of intracranial deep white matter lesions
24080022 High TGF beta is associated with myelofibrosis.
24078506 In accordance to the observed similarity between TGF-beta variants and miR-21 gene expression alterations in bladder tumors, treating 5637 bladder cancer cell line with TGF-beta recombinant protein caused a significant upregulation of miR-21.
24074435 TGFB1 gene polymorphisms may be associated with susceptibility to the development of Crohn's disease (CD), and IL10 gene polymorphisms appear to influence the CD phenotype in this admixed population.
24071738 OTUB1 enhances TGF-beta signaling by inhibiting the ubiquitylation and degradation of active SMAD2 and SMAD3.
24067469 Report the activation of TGFbeta/Smad signaling pathway in the airways of children with asthma despite regular inhaled corticosteroid treatment.
24065520 This is the first report showing the association between TGFB1 +869T>C polymorphism and schizophrenia.
24060592 Data suggest that the IL-10-1082 A>G (rs1800896), TGF-beta1-509 T>C (rs1800469), and TGF-beta1 T29C (rs1800470) SNPs play an important role in the risk of developing Silent myocardial ischemia (SMI).
24060183 TGF-beta1 G915C, G800A, and C509T gene polymorphism are not associated with the DN risk.
24056369 Transforming growth factor-beta3 (TGF-beta3) knock-in ameliorates inflammation due to TGF-beta1 deficiency while promoting glucose tolerance.
24049142 TGF-beta1, acting, in part, via mTOR, increases mitochondrial membrane potential and oxygen consumption, resulting in increased ROS generation and that this may contribute to podocyte injury.
24043696 Orai1 is expressed in the human endometrium and is up-regulated by SGK1 and TGFbeta1.
24040439 TGF-beta/Smad, integrin/integrin-linked kinase (ILK) and wnt/beta-catenin signaling pathways are involved in epithelial to mesenchymal transition in human renal fibrogenesis.
24026183 Obstructed kidneys from CD44v3 transgenic mice showed less tubular damage and myofibroblasts accumulation, which was associated with decreased TGF-beta1 signaling compared with kidneys from wild-type and CD44s transgenic mice.
24025717 TBX3 plays a pivotal role in mediating the antiproliferative and promigratory role of TGF-beta1 in breast epithelial and skin keratinocytes.
24023680 IgA1 complexes from IgA nephropathy patients could up-regulate the secretion of CXCL1 and TGF-beta1 in mesangial cells.
24023501 TGF-beta1 promoter is methylated in gastric cancer patients.
24016252 Our meta-analysis suggested that the TGF-beta1 +869C/T and -509C/T polymorphisms may be risk factors for developing hepatocellular carcinoma.[meta-analysis]
24015303 The synergistic effects of ET-1 on serum and TGF-beta1 involve ERK1/2 MAPK and may thus present a novel mode of action in the pathogenesis of pulmonary arterial hypertension.
24014274 These finding suggest that there is an increased expression of TGF-beta and CTGF, a TGF-beta regulated protein, and that this TGF-beta activation may be responsible for fibrosis in carpal tunnel syndrome patients.
24012048 Complicated malaria was associated with enhanced expression of IFN-gamma and TGF-beta but lower IL-2 and IL-12alpha in comparison to uncomplicated malaria.
24005672 The total CTGF production induced by TGF-beta in activated HSCs is therefore, to a large extent, dependent on the balance and integration of the canonical Smad3 and Stat3 signaling pathways
23996684 Single nucleotide polymorphism in TGFB1 gene is associated with ER-negative breast cancers only in American women of African ancestry.
23991075 features may be relevant to discriminate stage dependent TGF-beta functions for the design of efficient TGF-beta directed therapy in liver cancer
23990681 Lymphangiogenesis associates with fibrosis through the TGFbeta-vascular endothelial growth factor (VEGF)-C pathway.
23986795 Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of anti-inflammatory proteins IL-10 and TGF-beta
23982878 The present meta-analysis results suggest that TGF-b1 -509C/T variants may not contribute to the risk of breast cancer overall
23975370 TGFbeta1 Leu10Pro polymorphism contributes to the development of prostate cancer.
23973519 Urine marker TGFB1 may predict urinary tract impairment in children with myelodysplasia. and may differentiate at risk patients with either renal scarring or high detrusor leak point pressure.
23965869 IL-17 and TGF-beta1 may be involved in the occurrence and development of asthma, and they play important roles in asthma attack and aggravation.
23958565 Lungs of patients with schistosomiasis-associated pulmonary arterial hypertension have evidence of TGF-beta signaling in their remodeled pulmonary arteries.
23951322 The TGFBR2-875G>A contribution to an early relapse in androgen-deprivation therapy patients supports the involvement of TGFbeta1 pathway in castration-resistant prostate cancer.
23946447 These data suggest a dual role for TGFbeta signaling during lymphatic network morphogenesis in the skin.
23944366 reviews the two faces of TGF-beta signaling in the regulation of tumorigenesis.
23941979 The presence of the G/G genotype of TGFB1 SNP in Mexican patients was significantly associated with severity of liver fibrosis.
23940283 PARP-1 regulates expression of transforming growth factor-beta (TGF-beta) receptors and TGF-beta signaling in T cells
23937428 TGF-beta1 reduces BMP4 signaling in pulmonary artery smooth muscle cells, a response that is exacerbated on the background of reduced BMP responsiveness due to BMPR-II mutations.
23936495 Extracellular vesicles are potent stimulators of MMP-9, IL-6, TGF-beta1 and induce the secretion of extracellular EMMPRIN
23934170 Our findings indicate that Cf-GP inhibits AGS cell proliferation and migration by downregulating integrin expression via the TGF-b1-activated FAK/PI3K/AKT pathways.
23923066 A synergic action was noted between TGF-beta1, IL-4 and IL-17A in terms of induction of bronchial epithelial-mesenchymal transition
23921128 The activated TLR4/NANOG oncogenic pathway is linked to suppression of cytostatic TGF-beta signaling.
23917667 TGFbeta1 has a fundamental role in intestinal homeostasis and oral tolerance to low antigen doses.
23912699 The levels of p-EGFR in HCC and CHC patients show a highly significant difference between patients.
23911408 Data indicate that high levels of TGF-beta followed by adaptation of FoxP3(+) naive and memory (CD4(+)CD45RA(+)/RO(+)) T cells were observed as the principal underlying factors leading to higher generation of T reg cells during disease progression.
23904263 Studies suggest that tumor necrosis factor beta (TNF-beta) 252 A/G polymorphism is associated with the risk of gastric cancer, especially in Asians.
23904169 Our results suggest that Egr-3 is a transcription factor associated with TGF-beta1 expression and in vivo regulatory activity
23892434 TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.
23887657 This study observed only a modest increase, if any, in TGFbeta1 levels of female Pro-allele carriers of the L10P polymorphism.
23884197 Atrial fibroblasts show greater fibrotic and oxidative responses to TGF-beta1 than ventricular fibroblasts and suggest role for Nox4.
23880103 Serum TGFB1 was elevated in patients with classic prolapse as compared with the control group and the non-classic mitral valve prolapse group.
23877620 These findings indicate crosstalk between p38 and smad3 through TGF-beta1 in choriocarcinoma cells.
23873179 Polymorphisms in the TGFB1 gene is associated with uterine cervical cancer.
23872147 Our results suggest that elevated expression and tyrosine phosphorylation of p130Cas contributes to the resistance to TGF-beta-induced growth inhibition.
23867993 APRIL depletion induces cell cycle arrest and apoptosis partly through blocking noncanonical TGF-beta1/ERK.
23864144 Taken together, our meta-analysis did not provided an evidence of confirming association between TGF-beta1 (codon 10, codon 25, -509C/T) gene polymorphism and systemic sclerosis.
23861796 current epidemiological studies of TGF-beta1 T869C polymorphism are too inconsistent to draw a conclusion on the association with IS susceptibility.
23846138 role of p.R218C in TGFbeta1 on the mechanism of the disease, and the complications of it in bones and endocrine glands, remains unclear
23839959 Pulmonary endothelial cell injury in a scleroderma mouse strain triggers pulmonary hypertension and supports the underlying role of functional interplay between TGFbeta and VEGF.
23831640 These results suggest an important role for TGF-beta1 in osteosarcoma cell growth, with the induction of IGFBP-3 by TGF-beta1 serving in a negative-feedback loop to control cell growth by preventing activation of the IGF1R.
23830915 TGFbeta activation plays an important role in mechanotransduction.
23828577 TGF-beta1 regulates the cell cycle via survivin.
23827227 Serum TGFB1 levels in Alzheimer disease patients were significantly lower than in controls.
23824952 Missense p.Arg156Cys mutation in the TGFB1 gene is associated with camurati-Engelmann disease with obesity.
23824844 Similarly inhibits TGF-beta1-stimulated CCN2/CTGF expression.
23815594 The TGF-beta1 (codons 10 and 25) CC GG genotype, which was present in a relatively small proportion of the idiopathic pulmonary fibrosis (IPF) patients compared to the controls, was associated with decreased disease severity.
23804438 a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7.
23804301 we show that increased expression of SMalphaA protein during TGFb1-induced myofibroblast differentiation was associated with the formation of YB-1 oligomers exhibiting SMaA mRNA-binding activity.
23801826 Data suggest that serum TGFb1 level is not reliable biomarker for valvular fibrosis and calcification as adverse effects of dopamine agonist treatment in patients with prolactinomas, but serum TGFb1 may be useful biomarker for tumor invasiveness.
23801404 The density of macrophages in colorectal cancer is inversely correlated to TGF-beta1 expression and patients' survival.
23792529 identified the possible effect of interleukin 6 (IL-6), transforming growth factor beta 1 (TGFB1), and Fas SNPs on renal graft function
23792503 Patients who receive living-related liver transplantation due to inherited metabolic diseases are prone to higher oxidative stress, complement 5a activity, and serum transforming growth factor-ss1.
23792459 Our results integrated TGF-beta1 signals to SKP2 via Akt1 and c-Myc during epithelial-mesenchymal transition in melanoma.
23790953 Cc genotype of TGF-beta1 gene was found as a risk factor (odds ratio: 3.3) for low bone density in thalassemia major patients.
23786849 Thus, our findings highlight the cyclin D1/p21 signaling axis as a critical regulator of TGFb-mediated tumor growth initiation and local tumor cell invasion, both in vitro and in vivo.
23783250 results show that Brachyury expression is enhanced during TGF-beta1-induced epithelial-mesenchymal transition in human cancer cell lines and that a positive feedback loop is established between Brachyury and TGF-beta1 in mesenchymal-like tumor cells
23781096 This study showed that, by targeting SMURF2, NS3-4A appears to block the negative regulation of TGF-beta signaling, increasing the responsiveness of cells to TGF-beta.
23779087 a nuclear envelope-localized mechanism of inactivating TGF-beta signaling in which MAN1 competes with transcription factors for binding to Smad2 and Smad3 and facilitates their dephosphorylation by PPM1A.
23770290 our study here revealed that thyroid hormone T3 could inhibit TGFb1 induced renal tubular epithelial to mesenchymal transition by increasing miR34a expression.
23770288 the cellular location of the phosphorylation event and the importance of the linker region in regulation and expression of genes induced by TGF-b are covered.
23765061 Expression of TGFB1 in nasal epithelial cells was higher in nasal polyps compared to control mucosa.
23764028 Studies indicate that TGF-beta1 regulates inducible nitric oxide (NO) synthase (iNOS) both positively and negatively.
23762330 This is the first report elucidating a feedback regulation between miR-127 and the TGFbeta/c-Jun cascade in hepatocellular carcinoma migration via MMP13.
23762097 IL-10 and TGF-beta, as well as cell surface molecules PD-L1 and ICOS seem to be significantly involved in the redirection of dendritic cells towards tolerance induction in cancer. (Review)
23758278 The balance of positive and negative effects of TGF-beta1 signaling regulates the development of hematopoietic and endothelial progenitors in human pluripotent stem cells.
23748363 Urinary TGF-beta1 can be used as a biomarker for the early recognition of ongoing renal damage in patients with posterior urethral valves.
23747893 summarize recent knowledge of BMP-7 function and discuss attempts to use this cytokine as a drug to reverse TGF-beta-induced fibrogenesis
23741351 TGF-beta enhances IL-21-induced differentiation of human IL-21-producing CD4+ T cells via Smad3.
23731614 Expression of transforming growth factor-beta (4.3 +/- 1.4 vs 2.6 +/- 2.3, p = 0.01) and calponin (3.7 +/- 0.7 vs 0.6 +/- 1.1, p = 0.05) was lower from infants with vs without a PDA.
23729546 Data from 14-year-old girl and her father suggest that a missense mutation (R218C) in exon 4 of TGFB1 (transforming growth factor beta 1) can result in leg pain and other symptoms of Camurati-Engelman disease. [CASE REPORT]
23727026 we found that TGF-beta induced expression of CTGF was not mediated by TGF-b activated Smad signaling but mediated by TGF-beta activated Erk, JNK and p38 MAPK signaling
23717436 TGF-beta1 blockade and IL-12p70 production augments antitumor immunity in tumor and dendritic cell fusions.
23705641 High Transforming growth factor beta 1 is associated with bronchioloalveolar invasion in non-small cell lung cancer.
23704908 TGF-beta signaling pathway plays a dichotomous role in hepatocellular carcinogenesis.
23703862 This study identified a risk variant c.-509C > T and a risk haplotype G-T-T-G in the TGFB1 gene that contribute toward the susceptibility to otosclerosis.
23690936 Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFbeta signaling.
23690072 These data do not confirm a crucial role of TGF beta1 and TGF beta2 release in the development of posthemorrhagic hydrocephalus
23688102 study shows that there is strong association between TGF-beta1 29C/T gene polymorphisms and quantitative parameters of interdental papilla in patients with CP.
23685151 These findings for the first time define H2O2 as a signaling molecule that modulate Smad3 linker phosphorylation.
23684116 Increased TGF-beta1 bioavailability may contribute to the pathogenesis of polycystic ovarian syndrome and its increased risk for ovarian hyperstimulation.
23682558 Data suggest that targeting transforming growth factor-beta (TGF-beta) with either monoclonal antibodies or small molecule inhibitors is a potentially promising strategy for treating patients with myelofibrosis(MF) and that merits further investigation.
23682108 IL-13 potentiates airway remodelling through a mechanism involving collagen type I expression, TGF-beta1 and MMP-2
23668958 Endothelial cells may play a role in the induction and maintenance of EMT in tumor cells by constitutively releasing TGFbeta1 and TGFbeta2
23665678 Data indicate that TGF-beta1 and miR-450b-5p correlated in rhabdomyosarcoma (RMS) tissue.
23660507 Higher serum levels in patients with anaphylaxis
23657402 TGF-beta regulated the expression of miR-21 and fibrosis-related genes, and decreased Smad7 expression in scleroderma fibrosis.
23657067 The proliferation of human adipose-derived stem cells correlated with the concentration of PDGF-AB, BB and TGF-beta1.
23653379 Meta-analysis indicates that TGF-beta1 -509C/T (or +869T/C) polymorphisms are not associated with risk of hepatocellular carcinoma. [Meta-analysis]
23651239 Data show expression of TGF-beta1, TGF-beta2, BMP-4, and BMP-7 was increased in tumor-associated macrophages (TAMs) cocultured with pancreatic cancer cells, and vasohibin-1, VEGF-A, and vVEGF-C expression in pancreatic cancer cells was upregulated by TAMs.
23645040 This meta-analysis suggests a possible association between TGF-beta1 +869C/T promoter polymorphism and rheumatoid arthritis, especially in Asian population.
23640911 AEG-1 plays an important role in TGF-beta1-induced epithelial-mesenchymal transition through activation of p38 MAPK in proximal tubular epithelial cells.
23638863 No significant differences were observed between Graves disease and control subjects for IL-10, TGF-beta, and INF-gamma gene polymorphisms.
23631855 Tensile strain increases expression of CCN2 and COL2A1 by activating TGF-beta-Smad2/3 pathway in chondrocytic cells.
23623844 Data indicate that the level of TGF-beta did not differ between Common variable immunodeficiency (CVID) patients and controls while the amount of IL-10 was remarkably decreased in CVID patients.
23619257 Reduced expression of TGF-beta1 stimulates HBV replication and immune response.
23618868 Data indicate that all investigated cell lines secreted TGF-beta1 within the range previously reported for primary clear cell renal cell carcinoma (ccRCC) cell cultures.
23614931 Autoimmunity may have been triggered as a result of a decreased immunosuppressive effect induced by depressed TGF-beta1 levels in patients with systemic lupus erythematosus and Hashimoto's thyroiditis.
23612580 TGF-beta1 mediates selective atrial fibrosis in atrial fibrillation that occurs via TGF-beta Receptor 1/2 and the classical Smad pathway.
23604118 inactivation of TGF-beta signaling and loss of PTEN cooperate to drive intestinal cancer formation and progression by suppressing cell cycle inhibitors
23597094 TGFbeta1 gene polymorphisms interact with being overweight to influence the risk of large joint osteoarthritis
23589287 HAS2-dependent production of HA facilitates TGF-beta1-dependent fibroblast differentiation through promoting CD44 interaction with EGFR held within membrane-bound lipid rafts.
23583823 TGFbeta1 exposure alone significantly increased expression of alphaSMA, CTGF, COL1A1 and COL3A1
23583521 Caveolin-1 conveys a homeostatic antifibrotic function by regulating TGF-beta1 and its downstream signaling; regulating critical cellular processes involved in tissue repair; antagonizing cell proliferation.(Review)
23581259 results can suggest the lack of association between TNF-alpha 308 G/A and TGF-beta1 800 G/A gene polymorphisms with COPD development and airway resistance in Turkish population
23576639 Notch4-dependent antagonism of canonical TGF-beta1 signaling defines unique temporal fluctuations of SMAD3 activity in proximal tubular epithelial cells exposed to shear stress.
23567513 CCN2 in the intervertebral disc is regulated by TGF-beta and hypoxia via HIF-1alpha, the critical determinants that characterize the disc microenvironment in health and disease. (Review)
23555036 tumor-associated soluble and membrane-bound TGF-beta are involved in the regulation of intratumoral T cell differentiation and function in B-cell of non-Hodgkin lymphoma
23554457 Activation of canonical TGF-beta signalling is a major contributor to fibrosis and matrix remodelling in myxomatous mitral valve disease, and is amplified by increases in oxidative stress.
23552743 These findings uncovered a novel role of nestin in regulating TGF-beta1-induced epithelial-mesenchymal transition.
23548835 Gremlin gene silencing inhibited TGF-beta1-induced epithelial mesenchymal transition in kidney.
23548068 Variation in two TGFbeta1 tagged-SNPs (rs4803455, rs4803457) was associated with preeclampsia in black women.
23546898 The level of TGF beta1 was increasing during the admission and had the maximum level at the 7th day after diffuse axonal injury
23536722 important roles of endothelial cells within the prostate cancer microenvironment to promote the prostate cancer metastasis and provide new potential targets of IL-6-->AR-->TGFbeta-->MMP-9 signals to battle the prostate cancer metastasis
23532628 Our results indicate the association of IL-10 -3575 and TGF-b Leu10Pro gene variations with clinical characteristics.
23515495 Serum TGF-beta 1 and urinary MCP-1 can be used as the markers for detection of progression of diabetic nephropathy.
23515048 miR-30e/UCP2 axis has an important role in mediating TGF-beta1-induced epithelial-mesenchymal transition and kidney fibrosis.
23503840 The results of this study suggest that abnormal bone turnover marker levels, typical radiological findings and mutations in the TGFbeta1 gene are three important factors in the diagnosis of sporadic CamuratiEngelmann disease cases.
23500081 TGF-beta and TNF-alpha act in concert to activate apoptosis in gastric cancer cell through crosstalk between Smad and JNK signaling pathways.
23489193 ). There were no significant differences in CVF (p=0.12), in CTGF (p=0.60), and in TGF-beta expression (p=0.66) in the atrial myocardium between the two study groups.
23486522 Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and TGF-beta1 signaling in a paracrine manner.
23483604 TGF-beta may play a role in maintaining the homeostasis of intervertebral disc tissue.
23481710 TGF-beta1 is involved in reprogramming of Schwann cell phenotype, leading to transdifferentiation of neural cells in leprosy.
23479725 a novel signaling route whereby TGF-beta silences the expression of miR-584, resulting in enhanced PHACTR1 expression, and further leading to actin rearrangement and breast cancer cell migration.
23479171 We conclude that promoter region (-509C>T) and exon 1 (869T>C) polymorphisms are not associated with OPLL in the Korean population.
23468994 Inhibition of Smad signaling by expression of Smad7 and dominant negative Smad3 completely abolished TGF-beta-elicited expression of TIMP-3 in human fibroblasts
23467611 Using 3 different cancer cell lines whose tumorigenic properties are driven by TGF-beta signaling, we show that loss of Arkadia function, either by overexpression of dominant negative Arkadia or by siRNA-induced knockdown, inhibited lung colonization
23466425 The polymorphisms of tgf-beta1 promoter gene is associated with astham. TGF-beta1 modeulates the severity of asthma, and is associated with atopy of asthmatic subjects.
23465222 Calreticulin, integrin-alpha5, and TGF-beta1 expression was increased in atrial tissue in patients with AF and was related to AF type, suggesting that calreticulin is involved in the pathogenesis of AF in VHD patients.
23464518 This review will focus on the role of TGFB in T cell differentiation and discuss the prospect of TGFB as the therapeutic target of lung transplantation acceptance. [review]
23463512 thiol isomerases and thiol-disulfide exchange contribute to TGF-beta1 activation and identify a number of molecules that may participate in the process.
23459932 The identification and characterization of the Tgif mutant supports the role of TGFbeta signalling in the development of chronic OM.
23455751 TGFBI mutation p.Val631Asp was identified in all subjects.Analysis of this gene offer early diagnosis.
23447672 interaction between LPP and alpha-actinin, an actin cross-linking protein, is necessary for TGFbeta-induced migration and invasion of ErbB2-expressing breast cancer cells.
23446766 Study highlights the importance of TGFB1 gene for the development and progression of adolescent idiopathic scoliosis.
23437179 These findings provide a line of evidence that the effects of TGF-b and TNF-a were partially mediated by microRNAs, and shed light on the complexity of molecular events elicited by TGF-b and TNF-a.
23437118 HCV-induced transcription factors AP-1, Sp1, NF-kappaB and STAT-3 are involved in TGF-beta1 gene expression.
23435990 The TGF-beta1 C-509T CC genotype is associated with better overall survival in unresectable locally advanced non-small-cell lung cancer patients.
23434344 Atrial fibrillation patients without atrial mechanical contraction show higher TGF-beta1 expression than those with atrial mechanical contraction.
23428182 Advanced glycation end-products disrupt the barrier property of the blood brain barrier resulting in up-regulation of TGF-beta.
23426367 Transforming growth factor beta-regulated microRNA-29a promotes angiogenesis through targeting the phosphatase and tensin homolog in endothelium.
23424236 An unbalanced Nodal/transforming growth factor-beta and miR-376c expression may lead to the development of preeclampsia.
23421960 study demonstrates that the Tgfbr1/Pten 2cKO mouse model of human HNSCC is a useful model for assessing antitumor activity of new cancer therapeutic agents, and that IL-13-PE has therapeutic potential to treat human head and neck cancer
23420368 An meta-analysis suggests that the TGF-beta1 gene -C509T polymorphism would not be a risk factor for IgA nephropathy in Asians but might play a role in Europeans.
23419524 SMAD2 and SMAD3 acetylatation by P300-CBP is mediated by TGFB1 in human lung cancer cells.
23416968 OPN regulates the alternative activation of monocytes via TGF-beta1 and monocyte chemoattractant protein (MCP)-1, which may represent an additional mechanism for tumor immune escape.
23416372 Genetic variation in TGFB1 gene and risk of idiopathic recurrent pregnancy loss.
23403314 Data indicate that primary myelofibrosis-derived megakaryocytes expressed increased levels of bioactive Transforming Growth Factor beta1 (TGFbeta1).
23401019 High TGFB1 expression is associated with rectal cancer recurrence.
23399816 Data show that the TGF-beta1 codon 10 C allele, and C allele-containing genotypes may be susceptible, and T allele/TT genotype may be protective factors for type 2 diabetes (T2D) and diabetic nephropathy (DN.
23393376 Lower levels of circulating TGF-beta1 are associated with a poor disease prognosis in breast cancer
23390194 Data indicate that miR-21 potentiates TGF-beta signaling in hematopoietic cells via downregulation of SMAD7.
23382382 basal or TGFbeta-induced AhR down-modulation could be relevant in the acquisition of a motile EMT phenotype in both normal and transformed epithelial cells
23378223 Integrin inhibition is a promising strategy not only to inhibit angiogenesis, but also to block TGF-beta-controlled features of malignancy.
23363776 this study was to investigate the role of vitamin A in Foxp3 and TGF-beta gene expression in atherosclerotic patients.
23362262 TGFbeta-stimulated Smad 3 acts as a key node to instill a feedback loop between deptor down-regulation and TORC1/2 activation in driving mesangial cell hypertrophy
23361571 TGF-beta1 secreted by hepatocellular carcinoma induces the expression of the Foxp3 gene and suppresses antitumor immunity.
23359369 TGFbeta induces signaling involving PI3kinase-dependent Mnk-1-mediated phosphorylation of eIF4E at Ser-209 to facilitate mesangial cell hypertrophy. A role for dissociation of 4EBP-1-eIF4E complex for Mnk-1-mediated phosphorylation of eIF4E.
23358854 results demonstrate the functional diversity of cancer-associated fibroblasts and show that malignant keratinocytes from genetically unstable oral squamous cell carcinomas reinforce their malignant behavior by inducing fibroblast activation and senescence through ROS and TGF-beta-dependent mechanisms
23357697 TGF-beta1 induced injured MCL to express more LOXs than injured ACL (up to 1.85-fold in LOX, 2.21-fold in LOXL-1, 1.71-fold in LOXL-2, 2.52-fold in LOXL-3 and 3.32-fold in LOXL-4).
23352795 study shows that TGF-beta1 29 C/T polymorphism, but not -509 C/T and 788 C/T polymorphisms, may contribute to the development of chronic periodontitis in a sample of Iranian population
23352789 Activators/inhibitors of BMP and TGF-beta signaling play a critical upstream regulatory role in the mDA differentiation process in human pluripotent stem cells.
23344525 Suggest that the TGF-beta1 gene T869C polymorphism may affect susceptibility to idiopathic pulmonary fibrosis in Koreans.
23334061 Genetic variations in TGFbeta1 is associated with radiation-induced thoracic toxicities in non-small-cell lung cancer.
23333936 data support that TGFB1 genetic variation may be an important genetic determinant of mammographic density measure that predicts breast cancer risk, particularly in nulliparous women.
23325483 A Kashmiri population representing a homogeneous cohort of common ethnicity revalidates the significance of TGFbeta1 sequence variants, defining their relevance in the pathogenesis of the disease.
23322881 Significantly elevated levels of TGF-beta have been identified in the anterior chamber of glaucomatous eyes and has also been shown to directly cause increased intraocular pressure.
23319603 Data indicate a dominant role for TRB3 and MAPK-ERK/TGFbeta pathways as Notch regulators in breast cancer, establishing TRB3 as a potential therapeutic target.
23306609 the suppression of TGF-b1 induced TGF-b3 upregulation, and the suppression of TGF-b2 induced another unexpected downregulation of both TGF-b1 and TGF-b3.
23298711 Results indicate that the crosstalk between IL-6 and TGF-beta1 is associated with malignant features, including epithelial-mesenchymal transition (EMT), and Smad4 works in a dominant manner to promote these features.
23297769 Data suggest that GSK3 (glycogen synthase kinase 3) signaling regulates TGFb1- (transforming growth factor beta 1-) induced myofibroblast differentiation by up-regulating CREB1 (cAMP responsive element binding protein 1) phosphorylation/activation.
23295196 not needed for production of MMP-9 in nonsyndromic thoracic aortic aneurysm walls
23291965 the plasma concentration of TGF-beta1 in MFS patients might be a useful biomarker of the progression of aortic aneurysms.
23285029 The percentage of CD14(high)CD16(+) monocytes after trauma correlated strongly with plasma C-reactive protein (CRP) transforming growth factor-beta (TGF-beta), and macrophage colony-stimulating factor (M-CSF) levels.
23284751 Single Nucleotide Polymorphisms in transforming growth factor beta gene is associated with brain metastasis in non-small-cell lung cancer
23280075 In protocol biopsies from patients on low-dose cyclosporine regimen, expression of TGB-beta1 was not significantly increased along time since transplantation, and did not correlate with cyclosporine exposure.
23277357 Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor beta (TGFbeta)-induced breast cancer cell migration, invasion, and metastasis
23275154 This study emphasized the substantial role of the TGF-beta signaling pathway in colorectal cancer, especially in interaction with smoking.
23260996 TGF-beta1 might be useful as a tumor marker for astrocytomas.
23258796 The results of this study indicate robust stimulation of TGF-beta associated with macrophage infiltration within the human kidney with vascular occlusive disease.
23249950 Small interfering RNA-targeting atypical protein kinase C reduces TGFB-induced epithelial-to-mesenchymal transition.
23245944 Taken together, we show that, in contrast to asthma, COPD is characterised by elevated concentrations of both BDNF and TGF-beta1 in serum.
23243310 Transforming growth factor-beta directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas
23242839 Human irradiated vocal folds demonstrate molecular changes leading to fibrosis that underlie loss of vocal fold pliability occurring in patients following laryngeal irradiation. Transforming growth factor (TGF)-beta increased in the lamina propria.
23239467 64% of the Wnt signaling components regulated by demineralized bone powder were regulated similarly by the sum of effects by BMP-2 and by TGF-beta1.
23238947 TGFB1 induced human lung fibroblast proliferation is inhibited by mir-29 family members.
23232296 TGF-beta signaling reduces the suppressor activity of CD8(+)T suppressor cells.
23226264 GDF5 regulates TGF-beta-dependent angiogenesis in breast carcinoma cells.
23222298 Our findings indicate that DLX4 induces TOP2A expression but reduces sensitivity of tumor cells to TOP2 poisons by stimulating Ku-dependent repair of DSBs.
23220173 NSA2, which increases in diabetic nephropathy, may be involved in the actions of TGFbeta1 and contribute to the development of diabetic nephropathy
23209731 serum IL-10, TNFalpha and TGFbeta differentially associate with dengue disease severity
23208491 The interaction of tumor cells with resident fibroblasts results in hyperactivated TGFB1 signaling.
23207623 The results suggest a possible link between downregulation of LKB1 and overexpression of SMAD4 in SGTs.
23204521 results indicate that mitochondrial ROS are essential for normal TGF-beta-mediated gene expression and that targeting mitochondrial ROS might be beneficial in diseases associated with excessive fibrosis
23201680 findings reveal that the destruction of the TGF-beta-dependent barrier by COUP-TFII is crucial for the progression of PTEN-mutant prostate cancer into a life-threatening disease
23199655 no statistically significant associations between either fibrosis or overall toxicity and TGFB rs1800469 genotype were observed in patients received adjuvant breast radiotherapy (Meta-Analysis)
23192429 Expression of latent TGF-beta within the allograft kidney tubules may trigger the allograft rejection.
23185371 transcription factor GLI1 mediates TGFbeta1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism
23183523 miR-133a mediates TGF-beta-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis.
23179798 Cervical cancer cells secrete TGF-beta that inhibits lymphocyte proliferation and induces apoptosis in CD4+, but not in CD8+ lymphocytes.
23176363 Results of this study provide evidence of TGFB1 involvement in endometrial carcinogenesis and indicate potential use as a molecular indicator of disease progression.
23175152 Long-term low-dose asymmetric dimethylarginine induces TGF-beta expression in endothelial cells at both the gene and protein levels.
23167402 This meta-analysis suggested that TGF-beta1 C-509T polymorphism might contribute to a decreased risk on colorectal cancer susceptibility, especially for Caucasians.
23154409 The effects of conditional Tif1 gamma knockdown on lactation depend on both TGFbeta and SMAD4.
23129177 Transforming growth factor-beta 1 enhances the invasiveness of breast cancer cells by inducing a Smad2-dependent epithelial-to-mesenchymal transition.
23127773 no association between TGF-beta1 SNPs and radiation-induced lung toxicity in lung cancer European Caucasian patients
23126427 Review of roles TGF-beta, particularly TGF-beta1, and BMP-7 play in CKDs (chronic kidney diseases). Targeting the TGF-beta/Smad pathway or restoring BMP-7 signalling may represent novel therapies for CKDs.
23119075 Data indicate that TGF-beta1 was co-purified by specific i