Property Summary

NCBI Gene PubMed Count 129
PubMed Score 254.86
PubTator Score 353.62

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (14)

Disease log2 FC p
Barrett's esophagus 5.200 2.5e-02
esophageal adenocarcinoma 4.600 1.8e-02
intraductal papillary-mucinous adenoma (... 4.200 1.7e-03
intraductal papillary-mucinous carcinoma... 3.800 4.4e-03
intraductal papillary-mucinous neoplasm ... 4.100 2.0e-02
colon cancer 2.000 3.0e-05
active ulcerative colitis 3.816 3.9e-02
pancreatic cancer 4.100 7.4e-06
breast carcinoma 3.200 5.4e-03
fibroadenoma 4.000 1.4e-02
interstitial cystitis 2.400 1.5e-02
lung adenocarcinoma 1.400 3.3e-03
Breast cancer -2.000 3.0e-02
severe asthma 1.100 4.9e-03

Synonym

Accession P04155
Symbols pS2
BCEI
HPS2
HP1.A
pNR-2
D21S21

Gene

PANTHER Protein Class (2)

PDB

1HI7   1PS2  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (100)

PMID Text
26617749 we found TFF1 plays an oncogenic role in mucinous ovarian cancer
26390128 These results show increased levels of TFF1 and TFF3 in Chronic Kidney Disease patients with a pronounced elevation of urinary TFF1 in lower Chronic Kidney Disease stages.
26372254 Findings underscore an important protective role of TFF1 in abrogating H. pylori-mediated inflammation, a crucial hallmark of gastric tumorigenesis. Loss of TFF1 expression could be an important step in H. pylori-mediated gastric carcinogenesis.
26276775 trefoil factor 1 demonstrated breast specificity but was inferior to mammaglobin and GATA protein binding 3
26240479 These findings suggest that the rs184432 and rs225359 polymorphisms in TFF1 have protective effects for GC and contribute to the development of GC in Korean individuals.
26240291 We have established a novel, three-protein biomarker panel that is able to detect patients with early-stage pancreatic cancer in urine specimens:LYVE-1, REG1A, and TFF1 were selected as candidate biomarkers
25990322 This study provides a potent tool of rTFF1 production to be applied in gastric damage protection and wound healing. The protein sources from B. choshinensis were more efficient than rTFF1 produced by E. coli
25980439 Loss of TFF1 could be a critical step in promoting the H. pylori-mediated oncogenic activation of beta-catenin and gastric tumorigenesis.
25652124 Data indicate that microRNA miR218-5p negatively regulates trefoil factor 1 (TFF1) in an extracellular signal-regulated kinases Erk1/2-dependent manner.
25486181 Trefoil Factor 1 levels can influence copper excretion and copper related toxicity.
25199519 data clearly show that the expression of TFF3 in retinoblastoma cell lines is epigenetically regulated, whereas the level of TFF1 and TFF2 seems to be regulated by other or additional mechanisms
25015107 Western blot analysis data demonstrated that miR-504 abrogates TFF1-induced p53 protein expression and activity.
24843314 Determination of TFF1 status might identify patients at different risk for relapse and help in making decision on administering adjuvant therapy for early breast cancer patients during the first 3 years of follow-up.
24798994 Piezo1 is a novel TFF1 binding protein that is important for TFF1-mediated cell migration in gastric cancer cells.
24733740 overexpressed in chronic rhinosinusitis without nasal polyps
24503794 TFF1 missense mutations seem to be a rare event in colorectal carcinogenesis. However, serum TFF1 levels were significantly elevated in patients with colorectal carcinoma. Serum TFF1 may be a potential useful marker for patients with colorectal carcinoma.
24486742 miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells
24236136 the C-terminus of TFF1, involved in the binding of copper, is also able to selectively bind H. pylori RF-LPS.
24162262 Immunohistochemical expression of ERalpha, ERbeta, and TFF1 in type I and II ovarian tumors.
23942618 downregulation of TFF1 expression during gastric neoplastic transformation is associated with activation of the NF-kappaB pathway
23836323 High TFF1 expression is associated with doxorubicininduced apoptosis resistance.
23675462 MSK1 and MSK2 are required for maximal TFF 1 induction.
23627615 Analysis of TFF1 levels dynamics revealed that TFF1 levels kept steady state during the 5-day period. TFF1 levels were similar in patients with SIRS, sepsis and severe sepsis
23329884 Reduced expression of TFF1 and increased expression of TFF3 may play a role in the carcinogenesis of gastric cancer.
23291975 TFF1 expression is silenced by DNA methylation and is associated with tumor invasion and a poor survival in gastric cancer patients.
23266572 The capacity of TFF1 to enhance prostate cancer cell migration/invasion is mediated by transcriptional repression of E-CADHERIN.
22983508 Retinoblastoma cell lines with high TFF1 expression levels exhibited a selective down-regulation of cyclin-dependent kinase (CDK) 6, whereas CDK4 and CDK2 seem to be unaffected by TFF1 expression.
22944057 The expression of TFF1 protein increases in gastric ulcer but decreases in gastric ulcerocancer.
22842654 There is no direct molecular interaction between GKN1 and TFF1 in protein level in gastric cancer.
22642590 Over-expression of TFF1 could promote apoptosis of three cell lines and inhibit proliferation but had no pronounced effect on cell cycle
22382029 PIMT may act as a co-activator in ERalpha-mediated transcription of TFF1 through its recruitment to the promoter via interacting with ERalpha.
22286382 Report TFF1 expression in normal/diseased pancreas.
22093877 We found a statistically significant increased risk of gastric cancer associated with -394 TT genotypes
21946330 TFF1 promoter methylation is identified as a potential early marker of esophageal squamous cell carcinoma (ESCC).
21870107 gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner.
21747314 documented the extent and timing of TFF1 expression in pancreatic ductal adenocarcinoma
21490402 loss of TFF1 leads to activation of IKK complex-regulated NF-kappaB transcription factors and is an important event in shaping the NF-kappaB-mediated inflammatory response during the progression to gastric tumorigenesis
21472131 TFF mRNA/protein expression is indicative of cholangiocarcinoma progression, but not predictive for histological sub-type or survival time.
21451135 TFF1 as a soluble factor designed to act mainly to antagonize the OIS process to accelerate tumorigenesis.
21378170 histone modifications governing TFF1 transcription are mediated by estrogen receptor
21358676 expression of TFF1 stimulated the migration and invasion in the four cell lines. Forced TFF1 expression in MCF10A, MDA-MB-231 and MCF7 cells did not modify anchorage-dependent or -independent cell proliferation
21228366 TFF1, TFF2, and PDX1 were expressed only in lobular endocervical glandular hyperplasia.
21111741 Initiation of antral gastric cancer is associated with progressive epigenetic silencing of TFF1, which can be suppressed by the hormone gastrin.
21067798 Observational study of gene-disease association. (HuGE Navigator)
20981699 Novel mutation in HPS2 causing Hermansky-Pudlak Syndrome Type 2.
20494980 The TFF1 promoter is activated by serum depletion according to promoter reporter assays in HEK 293 cells.
20300195 MBD2 and ERalpha drive opposite effects on pS2 expression, which are associated with specific steady state levels of histone H3 acetylation and methylation marks
20213275 Cys58 and at least three Glu surrounding residues surrounding it, are essential to efficiently bind copper. Moreover, copper binding promotes the TFF1 homodimerization, thus increasing its motogenic activity in in vitro wound healing assays.
20198315 Observational study of gene-disease association. (HuGE Navigator)
20132413 Data show that genes overexpressed in breast carcinoma including TFF1, TFF3, FOXA1 and CA12.
20112343 Overexpression and promoter hypomethylation of TFF1 is associated with prostate cancer.
20063012 TFF1, TFF2, and TFF3 expression were localized systematically in surgical specimens from the urinary tract.
19851296 Observational study of gene-disease association. (HuGE Navigator)
19724895 Observational study of gene-disease association. (HuGE Navigator)
19692168 Observational study of gene-disease association. (HuGE Navigator)
19625176 Observational study of gene-disease association. (HuGE Navigator)
19589871 RNA interference-mediated depletion of TFF1 in mammary carcinoma cells significantly reduced anchorage-independent growth and migration.
19172695 circulating TFFs are not candidate markers of trisomy 21 in first-trimester pregnancies
19172291 This study demonstrates the over-expression in CTSE, in particular, and TFF1 in sessile serrated adenomas compared to both hyperplastic polyps and tubular adenomas.
19170196 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19132993 High sensitivity of pS2 expression in prostate carcinoma could make it a suitable marker for diagnosis of prostate carcinoma, especially in metastatic cases of unknown origin.
18927283 Decreased expression of TFF1 is associated with barrett's esophagus-associated high-grade dysplasia.
18846421 Breast cancer patients with pre-operative elevated bone marrow levels of Mammaglobin Aand/or trefoil factor 1 mRNA seem to constitute a small group of patients with a very poor prognosis.
18722547 in gastric cancer, expression of TFF1 in the absence of TFIZ1 is associated with lymph node metastasis
18676680 Observational study of gene-disease association. (HuGE Navigator)
18662686 These data suggest that highly active chromatin is not only permissive for transcription, but can override the requirement for the transcription factor at an inducible promoter.
18644870 Results describe the effects of estradiol on cyclin D1, PS2, and c-fos gene expression by measuring levels of RNA polymerase II on DNA templates, levels of nascent transcripts associated with RNA polymerase II, and levels of RNAs.
18543253 The co-occupancy of ERalpha and Sp1 on TFF1 promoter remains at similar level with and without estrogen, while that of ERalpha and Sp3 increased in the presence of estrogen
18515572 TFF1 protects Chang conjunctival cells from apoptosis induced by UV irradiation and benzalkonium chloride, by preventing caspase-8 activation.
18502057 TFF was present in term and preterm human milk with rapidly declining concentrations during the first weeks post partum.
18322525 Periodic, strand-specific methylation/demethylation occurs during transcriptional cycling of the pS2/TFF1 gene promoter on activation by oestrogens
17982272 The TFF1-GKN2 heterodimer and TFF2 differ characteristically by their binding to gastric mucins.
17651883 The effect of plant-derived and synthetic estrogens on estrogen receptor alpha medicated cell proliferation and estrogen-regulated pS2 expression in MCF-2 cells are reported.
17610997 reveal a new property of TFF1 and suggest that copper could influence its biological activities by interfering with the dimerization of the peptide and/or the interaction with mucins or putative TFF receptors.
17610997 The study demonstrated a selective binding affinity of TFF1 for copper.
17317669 IGF-1 induces phosphorylation and an increase of the AP1 complex, which is phosphorylated and binds to the pS2/TFF1 promoter, allowing recruitment of the chromatin remodeling factor Brg1 followed by binding of ERalpha via its interaction with c-Jun
17143957 Weaker expression of TFF1 in poorly-differentiated carcinoma may be related to the destruction of glands and cells in cancer tissues and the decrease in secretion of TFF1.
16861234 SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1
16830362 D21S1893-D21S1890 region may harbor candidate genes especially TFF (TFF1, TFF2, and TFF3) and serine protease family, which might be involved in tumor invasion and metastasis contributing to poor survival.
16718800 reduced expression of TFF1 and TFF2 in precancerous conditions and gastric cancer may be associated with the proliferation and malignant transformation of gastric mucosa
16715141 TFF1 and Cdc25A-B cooperate with other dominant oncogenic pathways to induce the adenoma and adenocarcinoma transitions.
16474375 TFF1 showed a statistically significant difference between early-onset gastric cancers and conventional gastric cancers.
16308573 urinary TFF1 is a CaOx crystal growth inhibitor with a potential pathophysiological role in nephrolithiasis
16142316 TFF1, TFF2, TFF3 and MUC5AC may have roles in pathogenesis of pterygium goblet cells
16142311 MUC5AC and MUC2, TFF1 and TFF3, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum
15967118 TFF-1 is lost late in the progression from Barrett's Esophagus to adenocarcinoma, while CES-2 is upregulated
15924415 This is the first demonstration that a member of the trefoil factor family of proteins, TFF1, is bound covalently to a brichos domain-containing protein, TFIZ1; this has profound implications for TFF1 function.
15849833 Decreased expression of TFF1 in carcinoma and its relativity to the differentiation suggests that TFF1 is related to gland and cell destruction of carcinoma.
15821928 trefoil factor family protein 1(TFF1)is expressed in inflamed non-neoplastic gallbladder epithelium and in low stage and low grade gallbladder carcinomas
15578191 The group of trefoil factor peptides (TFF1-3) are part of the protective mechanism operating in the intestinal mucosa and play a fundamental role in epithelial protection, repair, and restitution.
15541729 Sp1 or Sp3 aid in recruitment of HDACs and histone acetyltransferases (HATs) to mediate dynamic acetylation of histones associated with the TFF1 promoter
15177868 TFF1 is associated with the cell membrane of MCF-7 cells and is not linked via a GPI anchor.
15123808 H. pylori interacts avidly with the dimeric form of TFF1, and this interaction enables binding to gastric mucin, suggesting that TFF1 may act as a receptor for the organism in vivo
15115253 increased TFF1 and 2 concentrations found in serum from inflammatory bowel disease patients
14756547 TFF1 may play an as yet undetermined role in the tumorigenesis of colorectal carcinomas.
14563942 Decreased TFF1 expression may lead to increased cell proliferation and then to the invasive character of intrahepatic cholangiocarcinoma.
12613926 Expressed in conjunctiva in goblet cells. Review.
12379766 Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss in gastric carcinoma
12034770 The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis.
9855711 Specific DNA-protein interaction may explain the TFF peptides' cell specific expression pattern and altered levels in pathological conditions.

AA Sequence

MATMENKVICALVLVSMLALGTLAEAQTETCTVAPRERQNCGFPGVTPSQCANKGCCFDDTVRGVPWCFY      1 - 70
PNTIDVPPEEECEF                                                             71 - 84
//

Text Mined References (131)

PMID Year Title
26617749 2015 Trefoil factor 1 elevates the malignant phenotype of mucinous ovarian cancer cell through Wnt/?-catenin signaling.
26390128 2015 Trefoil Factor 1 Excretion Is Increased in Early Stages of Chronic Kidney Disease.
26372254 2015 Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis.
26276775 2015 Evaluating the utility of trefoil factor 1 as a mammary-specific immunostain compared and in conjunction with GATA-3 and mammaglobin in the distinction between carcinoma of breast and lung.
26240479 2015 Association between Promoter Polymorphisms of TFF1, TFF2, and TFF3 and the Risk of Gastric and Diffuse Gastric Cancers in a Korean Population.
26240291 2015 Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma.
25990322 2015 Functional expression of recombinant human trefoil factor 1 by Escherichia coli and Brevibacillus choshinensis.
25980439 2015 Loss of TFF1 promotes Helicobacter pylori-induced ?-catenin activation and gastric tumorigenesis.
25652124 2015 miR218-5p regulates the proliferation of gastric cancer cells by targeting TFF1 in an Erk1/2-dependent manner.
25486181 2015 Trefoil Factor 1 is involved in gastric cell copper homeostasis.
25416956 2014 A proteome-scale map of the human interactome network.
25199519 2014 Epigenetic control of trefoil factor family (TFF) peptide expression in human retinoblastoma cell lines.
25015107 2014 TFF1 activates p53 through down-regulation of miR-504 in gastric cancer.
24843314 2014 Trefoil factor 1 in early breast carcinoma: a potential indicator of clinical outcome during the first 3 years of follow-up.
24798994 2014 Piezo1 is as a novel trefoil factor family 1 binding protein that promotes gastric cancer cell mobility in vitro.
24733740 2014 Chronic rhinosinusitis without nasal polyps is associated with increased expression of trefoil factor family peptides.
24503794 Trefoil factor 1 gene alternations and expression in colorectal carcinomas.
24486742 2014 miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.
24236136 2013 Copper promotes TFF1-mediated Helicobacter pylori colonization.
24162262 2014 Immunohistochemical expression of ER?, ER?, and TFF1 in type I and II ovarian tumors.
23942618 2013 Activation of the NF-kB pathway downregulates TFF-1 in gastric carcinogenesis.
23836323 2013 The trefoil factor 1 (TFF1) protein involved in doxorubicin?induced apoptosis resistance is upregulated by estrogen in breast cancer cells.
23675462 2013 Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction.
23627615 2013 Trefoil factor 1 as a marker of mucosal damage of the gastrointestinal tract in children with sepsis.
23329884 2013 Reduced expression of TFF1 and increased expression of TFF3 in gastric cancer: correlation with clinicopathological parameters and prognosis.
23291975 2013 Loss of trefoil factor 1 is regulated by DNA methylation and is an independent predictive factor for poor survival in advanced gastric cancer.
23266572 2013 Trefoil factor 1 suppression of E-CADHERIN enhances prostate carcinoma cell invasiveness and metastasis.
22983508 2013 High trefoil factor 1 (TFF1) expression in human retinoblastoma cells correlates with low growth kinetics, increased cyclin-dependent kinase (CDK) inhibitor levels and a selective down-regulation of CDK6.
22944057 2012 [Expression and significance of trefoil factor 1 protein and serum pepsinogen in benign and malignant gastric ulcers].
22842654 2012 Role of trefoil factor 1 in gastric cancer and relationship between trefoil factor 1 and gastrokine 1.
22642590 2012 TFF1 inhibits proliferation and induces apoptosis of gastric cancer cells in vitro.
22382029 2012 Requirement of protein l-isoaspartyl O-methyltransferase for transcriptional activation of trefoil factor 1 (TFF1) gene by estrogen receptor alpha.
22286382 2012 Trefoil factor family peptides in normal and diseased human pancreas.
22158540 2011 Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
22093877 2012 Polymorphism of estrogen response element in TFF1 gene promoter is associated with an increased susceptibility to gastric cancer.
21982860 2012 A secreted protein microarray platform for extracellular protein interaction discovery.
21946330 2011 Identification of a DNA methylome signature of esophageal squamous cell carcinoma and potential epigenetic biomarkers.
21870107 2012 Gastrointestinal tract specific gene GDDR inhibits the progression of gastric cancer in a TFF1 dependent manner.
21747314 2011 Trefoil factor 1 stimulates both pancreatic cancer and stellate cells and increases metastasis.
21490402 2011 Loss of TFF1 is associated with activation of NF-?B-mediated inflammation and gastric neoplasia in mice and humans.
21472131 2011 Trefoil factors: tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma.
21451135 2011 Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process.
21378170 2011 The histone modifications governing TFF1 transcription mediated by estrogen receptor.
21358676 2011 Deficiency in trefoil factor 1 (TFF1) increases tumorigenicity of human breast cancer cells and mammary tumor development in TFF1-knockout mice.
21228366 2011 Aberrant expression of TFF1, TFF2, and PDX1 and their diagnostic value in lobular endocervical glandular hyperplasia.
21111741 2011 Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.
21067798 2011 Prothrombin haplotype associated with kidney stone disease in Northeastern Thai patients.
20981699 2010 Novel mutation causing Hermansky-Pudlak Syndrome Type 2.
20494980 2010 Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.
20300195 2010 A role for methyl-CpG binding domain protein 2 in the modulation of the estrogen response of pS2/TFF1 gene.
20213275 2010 Copper binds the carboxy-terminus of trefoil protein 1 (TFF1), favoring its homodimerization and motogenic activity.
20198315 2010 Association of genetic variants with hemorrhagic stroke in Japanese individuals.
20132413 2011 Gene expression signatures differentiate ovarian/peritoneal serous carcinoma from breast carcinoma in effusions.
20112343 2010 Promoter hypomethylation and upregulation of trefoil factors in prostate cancer.
20063012 2010 Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine.
19851296 2010 Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
19724895 2009 Association of gene polymorphisms with chronic kidney disease in Japanese individuals.
19692168 2010 Genetic susceptibility to distinct bladder cancer subphenotypes.
19625176 2009 PTEN identified as important risk factor of chronic obstructive pulmonary disease.
19589871 2009 Trefoil factor-1 (TFF1) enhances oncogenicity of mammary carcinoma cells.
19172695 2008 Circulating serum trefoil factors increase dramatically during pregnancy.
19172291 2009 Over-expression of cathepsin E and trefoil factor 1 in sessile serrated adenomas of the colorectum identified by gene expression analysis.
19170196 2009 Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
19132993 2008 pS2 (TFF1) expression in prostate carcinoma: correlation with steroid receptor status.
18927283 2008 Expression analysis of Barrett's esophagus-associated high-grade dysplasia in laser capture microdissected archival tissue.
18846421 2009 A small subgroup of operable breast cancer patients with poor prognosis identified by quantitative real-time RT-PCR detection of mammaglobin A and trefoil factor 1 mRNA expression in bone marrow.
18722547 2009 The trefoil factor interacting protein TFIZ1 binds the trefoil protein TFF1 preferentially in normal gastric mucosal cells but the co-expression of these proteins is deregulated in gastric cancer.
18676680 2008 Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
18662686 2008 Chromatin context dominates estrogen regulation of pS2 gene expression.
18644870 2008 Cotranscriptional splicing potentiates the mRNA production from a subset of estradiol-stimulated genes.
18543253 2008 Association of Sp3 and estrogen receptor alpha with the transcriptionally active trefoil factor 1 promoter in MCF-7 breast cancer cells.
18515572 2008 Trefoil factor TFF1-induced protection of conjunctival cells from apoptosis at premitochondrial and postmitochondrial levels.
18502057 2008 Trefoil factors in human milk.
18322525 2008 Cyclical DNA methylation of a transcriptionally active promoter.
17982272 2007 Biosynthesis of gastrokine-2 in the human gastric mucosa: restricted spatial expression along the antral gland axis and differential interaction with TFF1, TFF2 and mucins.
17651883 2007 Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells.
17610997 2007 Copper-binding activity of Trefoil factor 1 (TFF1): a new perspective in the study of the multifunctional roles of TFFs.
17317669 2007 Estrogen receptor alpha and the activating protein-1 complex cooperate during insulin-like growth factor-I-induced transcriptional activation of the pS2/TFF1 gene.
17242463 2007 Tissue localization of human trefoil factors 1, 2, and 3.
17143957 2006 Molecular forms of trefoil factor 1 in normal gastric mucosa and its expression in normal and abnormal gastric tissues.
16861234 2006 SET-mediated promoter hypoacetylation is a prerequisite for coactivation of the estrogen-responsive pS2 gene by PRMT1.
16830362 2006 Amplification of chromosome 21q22.3 harboring trefoil factor family genes in liver fluke related cholangiocarcinoma is associated with poor prognosis.
16718800 2006 Expression of trefoil factors 1 and 2 in precancerous condition and gastric cancer.
16715141 2006 Induction of the adenoma-carcinoma progression and Cdc25A-B phosphatases by the trefoil factor TFF1 in human colon epithelial cells.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
16697734 2006 Trefoil factor family-1 mutations enhance gastric cancer cell invasion through distinct signaling pathways.
16474375 2006 Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers.
16341674 2005 Transcriptome analysis of human gastric cancer.
16308573 2005 Identification of human urinary trefoil factor 1 as a novel calcium oxalate crystal growth inhibitor.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
16142316 2005 Trefoil factor family mRNA and protein expression in pterygium.
16142311 2005 Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum.
15967118 2005 Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas.
15924415 2005 Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C.
15849833 2005 Relationship between trefoil factor 1 expression and gastric mucosa injuries and gastric cancer.
15831516 2005 Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells.
15821928 2005 Analysis of trefoil factor family protein 1 (TFF1, pS2) expression in chronic cholecystitis and gallbladder carcinoma.
15578191 2005 Impaired mucosal regeneration in neonatal necrotising enterocolitis.
15541729 2005 Estrogen regulation of trefoil factor 1 expression by estrogen receptor alpha and Sp proteins.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15340161 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites.
15177868 2004 TFF1 is membrane-associated in breast carcinoma cell line MCF-7.
15123808 2004 Helicobacter pylori interacts with the human single-domain trefoil protein TFF1.
15115253 2004 Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease.
14756547 Cytosolic levels of an estrogen-induced breast cancer-associated peptide (TFF1/pS2) in colorectal cancer: clinical significance and relationship with steroid receptors.
14563942 2003 Aberrant expression of trefoil factor family 1 in biliary epithelium in hepatolithiasis and cholangiocarcinoma.
12613926 2002 Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12407144 2002 TFF peptides in the human efferent tear ducts.
12379766 2002 Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma.
10982763 2000 Somatic mutations of the trefoil factor family 1 gene in gastric cancer.
10950923 2000 Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.
10830953 2000 The DNA sequence of human chromosome 21.
10673290 2000 The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach.
9855711 1998 5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).
9355742 1997 Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58.
9096235 1997 High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein.
9070946 1997 The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3.
9043862 1996 Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression.
8521850 1995 NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide. Similarities to porcine spasmolytic peptide and evidence for a monomeric structure.
8405856 1993 Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach.
6324130 1984 Sequence of the pS2 mRNA induced by estrogen in the human breast cancer cell line MCF-7.
3838275 1985 Cloning of a gene expressed in human breast cancer and regulated by estrogen in MCF-7 cells.
3822834 1987 Structure of the human oestrogen-responsive gene pS2.
3261981 1988 Identification of a polypeptide secreted by human breast cancer cells (MCF-7) as the human estrogen-responsive gene (pS2) product.
3146413 1988 [Primary structure of human protein pS2].
3041593 1988 Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa.
2311759 1990 Expression of the pS2 gene in human gastric cancer cells derived from poorly differentiated adenocarcinoma.
2303034 1990 hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
2185238 1990 Complete primary structure of the human estrogen-responsive gene (pS2) product.
1707960 1991 Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry.