Tbio TFCP2L1 Transcription factor CP2-like protein 1

Protein Summary

Description

Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs) (PubMed:25215486, PubMed:26906118). With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity). Required for normal duct development in the salivary gland and kidney (By similarity). Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity). Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity). Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity). JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity). Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity). Modulates the placental expression of CYP11A1 (PubMed:10644752).

Uniprot Accession IDs

• Q9NZI6
• Q4ZG43

Gene Name

• TFCP2L1

Ensembl ID

• ENST00000263707
• ENSP00000263707
• ENSG00000115112

Symbol

• CRTR1
• LBP9
• LBP9
• CRTR1
• LBP-9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.85
virus perturbation	0.83
disease perturbation	0.79
biological process	0.72
transcription factor perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Cp2-like Protein 1

DTO Classes

Protein / Transcription Factor / Transcription Factor Cp2-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.71   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.71   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0