Tbio TFAP2A Transcription factor AP-2-alpha

Protein Summary

Description

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• P05549
• Q13777
• Q5TAV5
• Q8N1C6
• AP2-alpha

Gene Name

• TFAP2A

Ensembl ID

• ENST00000319516
• ENSP00000316516
• ENSG00000137203
• ENST00000379608
• ENSP00000368928
• ENST00000482890
• ENSP00000418541

Symbol

• AP2TF
• TFAP2
• AP-2
• BOFS
• AP2TF
• TFAP2
• AP-2alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
PubMedID	0.96
transcription factor perturbation	0.91
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Ap-2-alpha

DTO Classes

Protein / Transcription Factor / Transcription Factor Ap-2-alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 503.25   (req: < 5)

Gene RIFs: 175   (req: <= 3)

Antibodies: 509   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 503.25   (req: >= 5)

Gene RIFs: 175   (req: > 3)

Antibodies: 509   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0