| Tbio | Transcription factor A, mitochondrial |
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alzheimer Disease | 83 | 0.0 | 0.0 |
| Bowen's Disease | 3 | 0.0 | 0.0 |
| Ceroid lipofuscinosis, neuronal 1, infantile | 10 | 0.0 | 0.0 |
| Disease Models, Animal | 155 | 0.0 | 0.0 |
| MITOCHONDRIAL DNA DEPLETION SYNDROME 15 (HEPATOCEREBRAL TYPE) | 1 | 0.0 | 0.0 |
| Parkinson Disease, Secondary | 9 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Alzheimer's disease | 658 |
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 2.3e-06 |
| medulloblastoma, large-cell | 6241 | 3.6e-05 |
| lung cancer | 4740 | 1.5e-04 |
| ovarian cancer | 8520 | 3.9e-04 |
| osteosarcoma | 7950 | 4.7e-04 |
| nasopharyngeal carcinoma | 1058 | 4.7e-03 |
| Multiple myeloma | 1332 | 4.7e-03 |
| group 3 medulloblastoma | 4104 | 2.0e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.8e-02 |
| Rheumatoid arthritis | 1191 | 4.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.400 | 2.0e-02 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 3.8e-02 |
| lung cancer | 1.600 | 1.5e-04 |
| malignant mesothelioma | 1.500 | 2.3e-06 |
| medulloblastoma, large-cell | 2.300 | 3.6e-05 |
| Multiple myeloma | 1.474 | 4.7e-03 |
| nasopharyngeal carcinoma | 1.100 | 4.7e-03 |
| osteosarcoma | -1.688 | 4.7e-04 |
| ovarian cancer | 1.300 | 3.9e-04 |
| Rheumatoid arthritis | 1.200 | 4.7e-02 |
