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Tbio
TESPA1
Protein TESPA1

Protein Summary
Description
Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316577
  • ENSP00000312679
  • ENSG00000135426
  • ENST00000449076
  • ENSP00000400892
  • ENST00000524622
  • ENSP00000435622
  • ENST00000531122
  • ENSP00000433098
  • ENST00000532804
  • ENSP00000432030

Symbol
  • KIAA0748
  • HSPC257
  • ITPRID3
  • KIAA0748
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.7
tissue
0.55
cell type or tissue
0.52
biological process
0.51
phenotype
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.53   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.53   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0