Tbio TEAD3 Transcriptional enhancer factor TEF-5

Protein Summary

Description

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99594
• O95910
• Q5BJG7
• Q8N6Y4

Gene Name

• TEAD3

Ensembl ID

• ENST00000639578
• ENSP00000492431
• ENSG00000007866

Symbol

• TEAD5
• TEF5
• TEF5
• TEAD5
• TEF-5
• DTEF-1
• ETFR-1
• TEAD-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.74
biological process	0.64
transcription factor binding site profile	0.63
histone modification site profile	0.62
transcription factor	0.62

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcriptional Enhancer Factor Tef-5

DTO Classes

Protein / Transcription Factor / Transcriptional Enhancer Factor Tef-5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.9   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.9   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0