| Tbio | Transcription factor 20 |
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Comments
| Disease | Target Count |
|---|---|
| Schizophrenia | 503 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7933 | 1.5e-04 |
| psoriasis | 6685 | 2.2e-04 |
| lung cancer | 4473 | 5.3e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1795 | 2.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Barrett's esophagus | 185 | 3.766 | 1.9 |
| Vertebrobasilar insufficiency | 8 | 3.579 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| psoriasis | -1.200 | 2.2e-04 |
| osteosarcoma | -1.009 | 1.5e-04 |
| pancreatic ductal adenocarcinoma liver m... | 1.019 | 2.7e-02 |
| lung cancer | 1.100 | 5.3e-03 |
| PMID | Text | |
|---|---|---|
| 25228304 | mutations in TCF20 are associated with Autism spectrum disorders | |
| 24416372 | SPBP is a transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62. | |
| 24205348 | evolutionary conservation of chromatin binding of SPBP and RAI1 | |
| 21935435 | Study has identified SPBP as a transcriptional coactivator of AR. We also show that Pax6 inhibits SPBP-mediated enhancement of AR activity on the AR target gene probasin promoter, a repression that was partly reversed by increased expression of SPBP. | |
| 20816152 | Observational study of gene-disease association. (HuGE Navigator) | |
| 20564319 | Meta-analysis of gene-disease association. (HuGE Navigator) | |
| 20509872 | Observational study of gene-disease association. (HuGE Navigator) | |
| 20490451 | Observational study and meta-analysis of gene-disease association. (HuGE Navigator) | |
| 20161779 | Observational study of gene-disease association. (HuGE Navigator) | |
| 19720844 | Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) | |
| 19602701 | Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator) | |
| 19082521 | Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | |
| 18984664 | Observational study of gene-disease association. (HuGE Navigator) | |
| 18854154 | Knockdown of transcription factor 20 (AR1) (PDCD2L) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 | |
| 18701471 | Observational study of gene-disease association. (HuGE Navigator) | |
| 18591388 | Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | |
| 17913746 | Interaction between SPBP and TopBP1 was found to be mediated by the ePHD domain of SPBP and the BRCT6 domain of TopBP1. | |
| 15831449 | SPBP behaves as a repressor of activated ERalpha |
MQSFREQSSYHGNQQSYPQEVHGSSRLEEFSPRQAQMFQNFGGTGGSSGSSGSGSGGGRRGAAAAAAAMA 1 - 70 SETSGHQGYQGFRKEAGDFYYMAGNKDPVTTGTPQPPQRRPSGPVQSYGPPQGSSFGNQYGSEGHVGQFQ 71 - 140 AQHSGLGGVSHYQQDYTGPFSPGSAQYQQQASSQQQQQQVQQLRQQLYQSHQPLPQATGQPASSSSHLQP 141 - 210 MQRPSTLPSSAAGYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQSGQSYDGSYNVNAGSQYEGHNVGSN 211 - 280 AQAYGTQSNYSYQPQSMKNFEQAKIPQGTQQGQQQQQPQQQQHPSQHVMQYTNAATKLPLQSQVGQYNQP 281 - 350 EVPVRSPMQFHQNFSPISNPSPAASVVQSPSCSSTPSPLMQTGENLQCGQGSVPMGSRNRILQLMPQLSP 351 - 420 TPSMMPSPNSHAAGFKGFGLEGVPEKRLTDPGLSSLSALSTQVANLPNTVQHMLLSDALTPQKKTSKRPS 421 - 490 SSKKADSCTNSEGSSQPEEQLKSPMAESLDGGCSSSSEDQGERVRQLSGQSTSSDTTYKGGASEKAGSSP 491 - 560 AQGAQNEPPRLNASPAAREEATSPGAKDMPLSSDGNPKVNEKTVGVIVSREAMTGRVEKPGGQDKGSQED 561 - 630 DPAATQRPPSNGGAKETSHASLPQPEPPGGGGSKGNKNGDNNSNHNGEGNGQSGHSAAGPGFTSRTEPSK 631 - 700 SPGSLRYSYKDSFGSAVPRNVSGFPQYPTGQEKGDFTGHGERKGRNEKFPSLLQEVLQGYHHHPDRRYSR 701 - 770 STQEHQGMAGSLEGTTRPNVLVSQTNELASRGLLNKSIGSLLENPHWGPWERKSSSTAPEMKQINLTDYP 771 - 840 IPRKFEIEPQSSAHEPGGSLSERRSVICDISPLRQIVRDPGAHSLGHMSADTRIGRNDRLNPTLSQSVIL 841 - 910 PGGLVSMETKLKSQSGQIKEEDFEQSKSQASFNNKKSGDHCHPPSIKHESYRGNASPGAATHDSLSDYGP 911 - 980 QDSRPTPMRRVPGRVGGREGMRGRSPSQYHDFAEKLKMSPGRSRGPGGDPHHMNPHMTFSERANRSSLHT 981 - 1050 PFSPNSETLASAYHANTRAHAYGDPNAGLNSQLHYKRQMYQQQPEEYKDWSSGSAQGVIAAAQHRQEGPR 1051 - 1120 KSPRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDPSAQEAGRCLMSSDGLPNKGMELKHGSQKLQESCWD 1121 - 1190 LSRQTSPAKSSGPPGMSSQKRYGPPHETDGHGLAEATQSSKPGSVMLRLPGQEDHSSQNPLIMRRRVRSF 1191 - 1260 ISPIPSKRQSQDVKNSSTEDKGRLLHSSKEGADKAFNSYAHLSHSQDIKSIPKRDSSKDLPSPDSRNCPA 1261 - 1330 VTLTSPAKTKILPPRKGRGLKLEAIVQKITSPNIRRSASSNSAEAGGDTVTLDDILSLKSGPPEGGSVAV 1331 - 1400 QDADIEKRKGEVASDLVSPANQELHVEKPLPRSSEEWRGSVDDKVKTETHAETVTAGKEPPGAMTSTTSQ 1401 - 1470 KPGSNQGRPDGSLGGTAPLIFPDSKNVPPVGILAPEANPKAEEKENDTVTISPKQEGFPPKGYFPSGKKK 1471 - 1540 GRPIGSVNKQKKQQQPPPPPPQPPQIPEGSADGEPKPKKQRQRRERRKPGAQPRKRKTKQAVPIVEPQEP 1541 - 1610 EIKLKYATQPLDKTDAKNKSFYPYIHVVNKCELGAVCTIINAEEEEQTKLVRGRKGQRSLTPPPSSTESK 1611 - 1680 ALPASSFMLQGPVVTESSVMGHLVCCLCGKWASYRNMGDLFGPFYPQDYAATLPKNPPPKRATEMQSKVK 1681 - 1750 VRHKSASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRRHRSEDCGGGPRSLSRGLPCKKAATEGSSEKT 1751 - 1820 VLDSKPSVPTTSEGGPELELQIPELPLDSNEFWVHEGCILWANGIYLVCGRLYGLQEALEIAREMKCSHC 1821 - 1890 QEAGATLGCYNKGCSFRYHYPCAIDADCLLHEENFSVRCPKHKPPLPCPLPPLQNKTAKGSLSTEQSERG 1891 - 1960 //
| PMID | Year | Title | |
|---|---|---|---|
| 25772364 | 2015 | SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. | |
| 25755297 | 2015 | System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability. | |
| 25228304 | 2014 | De novo and rare inherited mutations implicate the transcriptional coregulator TCF20/SPBP in autism spectrum disorder. | |
| 25218447 | 2014 | Uncovering global SUMOylation signaling networks in a site-specific manner. | |
| 25114211 | 2014 | Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. | |
| 25056061 | 2014 | Biological insights from 108 schizophrenia-associated genetic loci. | |
| 24416372 | 2014 | SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1. | |
| 24205348 | 2013 | A phylogenetic study of SPBP and RAI1: evolutionary conservation of chromatin binding modules. | |
| 24129315 | 2014 | Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. | |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. | |
| 22658674 | 2012 | Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. | |
| 21935435 | 2011 | Pax6 represses androgen receptor-mediated transactivation by inhibiting recruitment of the coactivator SPBP. | |
| 21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. | |
| 20816152 | 2010 | Obesity and diabetes genetic variants associated with gestational weight gain. | |
| 20564319 | 2010 | Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. | |
| 20509872 | 2010 | Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. | |
| 20490451 | 2010 | Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. | |
| 20161779 | 2010 | Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. | |
| 20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. | |
| 19720844 | 2009 | Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study. | |
| 19690332 | 2009 | Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. | |
| 19602701 | 2009 | Underlying genetic models of inheritance in established type 2 diabetes associations. | |
| 19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. | |
| 19082521 | 2009 | Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. | |
| 18984664 | 2009 | Common type 2 diabetes risk gene variants associate with gestational diabetes. | |
| 18701471 | 2008 | Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. | |
| 18669648 | 2008 | A quantitative atlas of mitotic phosphorylation. | |
| 18591388 | 2008 | Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. | |
| 17913746 | 2007 | The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription. | |
| 17081983 | 2006 | Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | |
| 15831449 | 2005 | SPBP is a phosphoserine-specific repressor of estrogen receptor alpha. | |
| 15592455 | 2005 | Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. | |
| 15302935 | 2004 | Large-scale characterization of HeLa cell nuclear phosphoproteins. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 10995766 | 2000 | The nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activators. | |
| 10849425 | 2000 | Interaction between the transcription factor SPBP and the positive cofactor RNF4. An interplay between protein binding zinc fingers. | |
| 10591208 | 1999 | The DNA sequence of human chromosome 22. | |
| 9730594 | 1998 | Assignment of AR1, transcription factor 20 (TCF20), to human chromosome 22q13.3 with somatic cell hybrids and in situ hybridization. | |
| 9179496 | 1997 | Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. | |
| 8889548 | 1996 | Normalization and subtraction: two approaches to facilitate gene discovery. | |
| 8663478 | 1996 | Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. | |
| 7760812 | 1995 | Molecular characterization of a novel transcription factor that controls stromelysin expression. |
