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  5. TBC1 domain family member 8

Tdark TBC1 domain family member 8

May act as a GTPase-activating protein for Rab family protein(s).

 Comments

Property Summary

NCBI Gene PubMed Count 10
PubMed Score 0.48
PubTator Score 27.15

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9
Disease Target Count Z-score Confidence
Osteoporosis 363 0.0 2.7

Expression

  Differential Expression (4)

Disease log2 FC p
atypical teratoid / rhabdoid tumor -1.200 3.0e-04
group 3 medulloblastoma 1.200 9.2e-04
malignant mesothelioma 3.600 1.7e-09
mucosa-associated lymphoid tissue lympho... 1.133 2.9e-02

Synonym

Accession O95759 A6NDL4 A8K9W1 B9A6K4 Q53SQ4 Q9UQ32
Symbols AD3
VRP
HBLP1
GRAMD8
TBC1D8A

Gene

TBC1D8

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (6)

 GO Function (2)

 GO Component (3)

 GO Process (5)

 Compartment GO Term (7)

 GWAS Trait (5)

 HCA RNA Cell Line (56)

See all...

Pathway (1)

Gene RIF (2)

AA Sequence 

MWLKPEEVLLKNALKLWVTQKSSCYFILQRRRGHGEGGGRLTGRLVGALDAVLDSNARVAPFRILLQVPG      1 - 70
SQVYSPIACGATLEEINQHWDWLEQNLLHTLSVFDNKDDIASFVKGKVKALIAEETSSRLAEQEEEPEKF     71 - 140
REALVKFEARFNFPEAEKLVTYYSCCCWKGRVPRQGWLYLSINHLCFYSFFLGKELKLVVPWVDIQKLER    141 - 210
TSNVFLTDTIRITTQNKERDFSMFLNLDEVFKVMEQLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEA    211 - 280
RAQNEFFRAFFRLPRKEKLHAVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGCCKIILPLREVVSIE    281 - 350
KMEDTSLLPHPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDDMASLVFHSTSM    351 - 420
CSDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQQSGSQSPDSRMSREQIKISLWNDHFVEYGRTV    421 - 490
CMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPE    491 - 560
HPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVCERMLPDYFNHRVI    561 - 630
GAQVDQSVFEELIKGHLPELAEHMNDLSALASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLG    631 - 700
LAVLEANAEDLCSSKDDGQALMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIRDSYEK    701 - 770
FGDQSVEQIEHLRYKHRIRVLQGHEDTTKQNVLRVVIPEVSILPEDLEELYDLFKREHMMSCYWEQPRPM    771 - 840
ASRHDPSRPYAEQYRIDARQFAHLFQLVSPWTCGAHTEILAERTFRLLDDNMDQLIEFKAFVSCLDIMYN    841 - 910
GEMNEKIKLLYRLHIPPALTENDRDSQSPLRNPLLSTSRPLVFGKPNGDAVDYQKQLKQMIKDLAKEKDK    911 - 980
TEKELPKMSQREFIQFCKTLYSMFHEDPEENDLYQAIATVTTLLLQIGEVGQRGSSSGSCSQECGEELRA    981 - 1050
SAPSPEDSVFADTGKTPQDSQAFPEAAERDWTVSLEHILASLLTEQSLVNFFEKPLDMKSKLENAKINQY   1051 - 1120
NLKTFEMSHQSQSELKLSNL                                                     1121 - 1140
//

Text Mined References (12)

PMID Year Title