Tdark TBC1D8 TBC1 domain family member 8

Protein Summary

Description

May act as a GTPase-activating protein for Rab family protein(s).

Uniprot Accession IDs

• O95759
• A6NDL4
• A8K9W1
• B9A6K4
• Q53SQ4
• Q9UQ32

Gene Name

• TBC1D8

Ensembl ID

• ENST00000376840
• ENSP00000366036
• ENSG00000204634

Symbol

• VRP
• AD3
• VRP
• HBLP1
• GRAMD8
• TBC1D8A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
histone modification site profile	0.83
transcription factor binding site profile	0.8
disease perturbation	0.79
gene perturbation	0.75

Protein Classes

PANTHER Classes

Protein / Hydrolase / Tbc1 Domain Family Member 8

Protein / Enzyme Modulator / G-protein Modulator / Tbc1 Domain Family Member 8

Protein / ... / Cysteine Protease / Tbc1 Domain Family Member 8

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Tbc1 Domain Family Member 8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0