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Tbio
TBC1D3
TBC1 domain family member 3

Protein Summary
Description
Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620215
  • ENSP00000478683
  • ENSG00000274611

Symbol
  • PRC17
  • TBC1D3A
  • PRC17
  • TBC1D3
  • TBC1D3A
  • TBC1D3D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.61
tissue
0.55
cell line
0.47
transcription factor
0.4
biological term
0.38


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.53   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.53   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0