TBC1D15
TBC1 domain family member 15
Protein Summary
Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity). This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
- ENST00000319106
- ENSP00000318262
- ENSG00000121749
- ENST00000485960
- ENSP00000420678
- ENST00000550746
- ENSP00000448182
- RAB7-GAP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.91 | ||
histone modification site profile | 0.8 | ||
interacting protein | 0.76 | ||
kinase perturbation | 0.76 | ||
microRNA | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.47 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 78 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.47 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 78 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0