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Tbio
TARM1
T-cell-interacting, activating receptor on myeloid cells protein 1

Protein Summary
Description
May act as receptor (By similarity). Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface (PubMed:26311901). Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432826
  • ENSP00000439454
  • ENSG00000248385
  • ENST00000611088
  • ENSP00000479824
  • ENSG00000276145
  • ENST00000611419
  • ENSP00000478234
  • ENSG00000275806
  • ENST00000612678
  • ENSP00000482624
  • ENSG00000275123
  • ENST00000614463
  • ENSP00000480049
  • ENSG00000276355
  • ENST00000615726
  • ENSP00000479185
  • ENSG00000275384
  • ENST00000619320
  • ENSP00000479062
  • ENSG00000276604
  • ENST00000620140
  • ENSP00000477830
  • ENST00000620398
  • ENSP00000479374
  • ENSG00000273875
  • ENST00000620707
  • ENSP00000480377
  • ENSG00000277178
  • ENST00000622245
  • ENSP00000478822
  • ENSG00000274889

Symbol
  • OLT-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.55
chemical
0.41
tissue
0.38
disease
0.36
cellular component
0.33


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0