Tbio TAMM41 Phosphatidate cytidylyltransferase, mitochondrial

Protein Summary

Description

Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity).

Uniprot Accession IDs

• Q96BW9
• B4DIY7
• C9J2U4

Gene Name

• TAMM41

Ensembl ID

• ENST00000273037
• ENSP00000273037
• ENSG00000144559
• ENST00000444133
• ENSP00000388598
• ENST00000455809
• ENSP00000398596

Symbol

• C3orf31
• RAM41
• TAM41
• C3orf31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
histone modification site profile	0.78
transcription factor binding site profile	0.78
transcription factor perturbation	0.74
transcription factor	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.08   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.08   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0