Tbio TACC2 Transforming acidic coiled-coil-containing protein 2

Protein Summary

Description

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95359
• Q4VXL0
• Q4VXL3
• Q4VXL6
• Q4VXL7
• Q5U5T7
• Q86WG6
• Q86WG7
• Q8TCK9
• Q9BVQ1
• Q9NZ41
• Q9NZR5

Gene Name

• TACC2

Ensembl ID

• ENST00000260733
• ENSP00000260733
• ENSG00000138162
• ENST00000334433
• ENSP00000334280
• ENST00000358010
• ENSP00000350701
• ENST00000360561
• ENSP00000353763
• ENST00000369000
• ENSP00000357996
• ENST00000369005
• ENSP00000358001
• ENST00000513429
• ENSP00000425062

Symbol

• AZU-1
• ECTACC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
co-expressed gene	0.93
transcription factor	0.79
kinase perturbation	0.76
PubMedID	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.73   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.73   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0