Tchem TAC3 Tachykinin-3

Protein Summary

Description

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function. This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q9UHF0
• Q6IAG2
• Q71BC6
• Q71BC9

Gene Name

• TAC3

Ensembl ID

• ENST00000300108
• ENSP00000300108
• ENSG00000166863
• ENST00000357616
• ENSP00000350236
• ENST00000379411
• ENSP00000368721
• ENST00000393867
• ENSP00000377445
• ENST00000415231
• ENSP00000402995
• ENST00000423597
• ENSP00000416292
• ENST00000438756
• ENSP00000408131
• ENST00000441881
• ENSP00000408208
• ENST00000458521
• ENSP00000404056
• ENST00000615887
• ENSP00000483110

Symbol

• NKNB
• NKB
• HH10
• NKNB
• PRO1155
• ZNEUROK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.72
gene perturbation	0.6
biological term	0.56
disease perturbation	0.56
pathway	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.44   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 248   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.44   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0