| Tbio | Synaptotagmin-like protein 4 |
Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| astrocytoma | 1146 | 1.2e-16 |
| ovarian cancer | 8520 | 1.3e-09 |
| osteosarcoma | 7950 | 4.5e-06 |
| Astrocytoma, Pilocytic | 3081 | 3.5e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 9.2e-04 |
| nasopharyngeal carcinoma | 1058 | 2.1e-03 |
| pancreatic carcinoma | 562 | 2.4e-03 |
| pancreatic cancer | 2398 | 2.4e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.0e-03 |
| glioblastoma | 5792 | 7.0e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.1e-02 |
| medulloblastoma, large-cell | 6241 | 1.5e-02 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.6e-02 |
| spina bifida | 1074 | 1.7e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.8e-02 |
| group 3 medulloblastoma | 4104 | 2.7e-02 |
| Pick disease | 1894 | 2.9e-02 |
| pediatric high grade glioma | 1064 | 3.9e-02 |
| oligodendroglioma | 2850 | 4.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Griscelli syndrome | 24 | 3.968 | 2.0 |
| Branchiootic syndrome | 12 | 3.566 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 2.400 | 1.2e-16 |
| Astrocytoma, Pilocytic | 2.000 | 3.5e-05 |
| atypical teratoid / rhabdoid tumor | -1.100 | 1.6e-02 |
| glioblastoma | 1.400 | 7.0e-03 |
| group 3 medulloblastoma | 1.100 | 2.7e-02 |
| intraductal papillary-mucinous adenoma (... | 1.600 | 9.2e-04 |
| intraductal papillary-mucinous carcinoma... | 1.700 | 5.0e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.200 | 1.8e-02 |
| medulloblastoma, large-cell | -1.100 | 1.5e-02 |
| nasopharyngeal carcinoma | -1.200 | 2.1e-03 |
| oligodendroglioma | 1.700 | 4.6e-02 |
| osteosarcoma | -3.187 | 4.5e-06 |
| ovarian cancer | -2.200 | 1.3e-09 |
| pancreatic cancer | 1.200 | 2.4e-03 |
| pancreatic carcinoma | 1.200 | 2.4e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.781 | 1.1e-02 |
| pediatric high grade glioma | 1.100 | 3.9e-02 |
| Pick disease | 1.600 | 2.9e-02 |
| spina bifida | -2.347 | 1.7e-02 |
MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSDRTCARCQESL 1 - 70 GRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFYDQKVNRFAYRTGSEIIRMSL 71 - 140 RHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSD 141 - 210 STSRRDSLDKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRP 211 - 280 EDVVHESGSLGDRSKSVPGLNVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGD 281 - 350 FGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTI 351 - 420 NPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPT 421 - 490 GLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRN 491 - 560 KASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVV 561 - 630 DWMDSTGEEVSLWQKMRQYPGSWAEGTLQLRSSMAKQKLGL 631 - 671 //
