| Tbio | Switch-associated protein 70 |
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 3.0e-18 |
| Duchenne muscular dystrophy | 601 | 5.3e-08 |
| Breast cancer | 3578 | 1.2e-07 |
| ependymoma | 4679 | 1.2e-06 |
| Astrocytoma, Pilocytic | 3081 | 1.3e-05 |
| ulcerative colitis | 1819 | 2.0e-05 |
| ovarian cancer | 8520 | 2.6e-05 |
| Pick disease | 1894 | 7.1e-05 |
| tuberculosis | 2010 | 9.3e-05 |
| Down syndrome | 499 | 1.4e-03 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 1.5e-03 |
| primary Sjogren syndrome | 735 | 2.1e-03 |
| invasive ductal carcinoma | 2951 | 2.4e-03 |
| Waldenstrons macroglobulinemia | 765 | 2.7e-03 |
| gastric carcinoma | 807 | 4.1e-03 |
| glioblastoma | 5792 | 4.2e-03 |
| dermatomyositis | 966 | 1.0e-02 |
| lung cancer | 4740 | 1.2e-02 |
| aldosterone-producing adenoma | 665 | 1.8e-02 |
| medulloblastoma, large-cell | 6241 | 2.7e-02 |
| spina bifida | 1074 | 4.0e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.3e-02 |
| astrocytic glioma | 2597 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| X-linked hyper IgM syndrome | 4 | 3.025 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| aldosterone-producing adenoma | -1.178 | 1.8e-02 |
| astrocytic glioma | -1.300 | 4.5e-02 |
| Astrocytoma, Pilocytic | 1.200 | 1.3e-05 |
| autosomal dominant Emery-Dreifuss muscul... | 1.144 | 1.5e-03 |
| Breast cancer | -1.200 | 1.2e-07 |
| dermatomyositis | 1.100 | 1.0e-02 |
| Down syndrome | 1.300 | 1.4e-03 |
| Duchenne muscular dystrophy | 1.042 | 5.3e-08 |
| ependymoma | 1.300 | 1.2e-06 |
| gastric carcinoma | 1.700 | 4.1e-03 |
| glioblastoma | 1.100 | 4.2e-03 |
| intraductal papillary-mucinous adenoma (... | -1.200 | 4.3e-02 |
| invasive ductal carcinoma | -1.400 | 2.4e-03 |
| lung cancer | -1.300 | 1.2e-02 |
| lung carcinoma | -1.300 | 3.0e-18 |
| medulloblastoma, large-cell | -1.100 | 2.7e-02 |
| ovarian cancer | -1.100 | 2.6e-05 |
| Pick disease | 1.200 | 7.1e-05 |
| primary Sjogren syndrome | 1.200 | 2.1e-03 |
| spina bifida | -1.156 | 4.0e-02 |
| tuberculosis | -1.200 | 9.3e-05 |
| ulcerative colitis | 1.400 | 2.0e-05 |
| Waldenstrons macroglobulinemia | 1.293 | 2.7e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYM 1 - 70 PYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWVIFNFLSEDKYPLIIVSEEIE 71 - 140 YLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILD 141 - 210 VLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCF 211 - 280 DKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANES 281 - 350 KQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVR 351 - 420 ELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRV 421 - 490 LKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITN 491 - 560 WGPAAFTEAELEEREKNWKEKKTTE 561 - 585 //
