STOML1
Stomatin-like protein 1
Protein Summary
May play a role in cholesterol transfer to late endosomes (PubMed:19696025). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202).
- ENST00000316900
- ENSP00000319323
- ENSG00000067221
- ENST00000316911
- ENSP00000319384
- ENST00000359750
- ENSP00000352788
- ENST00000541638
- ENSP00000442478
- ENST00000564777
- ENSP00000456343
- SLP1
- UNC24
- SLP-1
- STORP
- hUNC-24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.98 | ||
transcription factor binding site profile | 0.88 | ||
transcription factor perturbation | 0.74 | ||
tissue sample | 0.72 | ||
transcription factor | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.14 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 122 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.14 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 122 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0