STOM
Erythrocyte band 7 integral membrane protein
Protein Summary
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
- ENST00000286713
- ENSP00000286713
- ENSG00000148175
- ENST00000347359
- ENSP00000339607
- BND7
- EPB72
- BND7
- EPB7
- EPB72
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
interacting protein | 0.96 | ||
disease perturbation | 0.95 | ||
kinase perturbation | 0.93 | ||
small molecule perturbation | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 232.6 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 241 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 232.6 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 241 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0