Tbio STK40 Serine/threonine-protein kinase 40

Protein Summary

Description

May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.

Uniprot Accession IDs

• Q8N2I9
• D3DPS8
• Q5VTK8
• Q5VTK9
• Q6ZMN1
• Q8N2J8
• Q8N3I6
• Q96HN6
• Q96I44
• Q9BSA3
• Q9H7H6

Gene Name

• STK40

Ensembl ID

• ENST00000359297
• ENSP00000352245
• ENSG00000196182
• ENST00000373129
• ENSP00000362221
• ENST00000373130
• ENSP00000362222
• ENST00000373132
• ENSP00000362224

Symbol

• SGK495
• SHIK
• SHIK
• SgK495

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
molecular function	0.91
disease perturbation	0.83
transcription factor	0.82
microRNA	0.81

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Serine/threonine-protein Kinase 40

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Sgk495 Family / Serine/threonine-protein Kinase 40

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.85   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.85   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0