Tchem STK19 Serine/threonine-protein kinase 19

Protein Summary

Description

Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues. This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P49842
• A6NF95
• A6NFW8
• B0QZR5
• Q13159
• Q31617
• Q5JP77
• Q5ST72
• Q5ST75

Gene Name

• STK19

Ensembl ID

• ENST00000375331
• ENSP00000364480
• ENSG00000204344
• ENST00000375333
• ENSP00000364482
• ENST00000383327
• ENSP00000372817
• ENSG00000206342
• ENST00000424104
• ENSP00000393272
• ENSG00000236250
• ENST00000425138
• ENSP00000395028
• ENSG00000234947
• ENST00000426802
• ENSP00000389352
• ENSG00000226257
• ENST00000431383
• ENSP00000403479
• ENSG00000226033
• ENST00000433397
• ENSP00000395864
• ENST00000438256
• ENSP00000391798
• ENST00000444147
• ENSP00000399915
• ENST00000452688
• ENSP00000413766

Symbol

• G11
• RP1
• G11
• RP1
• D6S60
• D6S60E
• HLA-RP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
drug perturbation	0.87
phenotype	0.79
kinase perturbation	0.71
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.08   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.08   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0