Tbio STEAP2 Metalloreductase STEAP2

Protein Summary

Description

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NFT2
• A4D1F1
• G5E9C6
• Q6UXN6
• Q6YPB1
• Q8IUE7

Gene Name

• STEAP2

Ensembl ID

• ENST00000287908
• ENSP00000287908
• ENSG00000157214
• ENST00000394621
• ENSP00000378119
• ENST00000394622
• ENSP00000378120
• ENST00000394626
• ENSP00000378123
• ENST00000394629
• ENSP00000378125
• ENST00000394632
• ENSP00000378128

Symbol

• PCANAP1
• STAMP1
• STMP
• IPCA1
• PUMPCn
• STAMP1
• PCANAP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.8
kinase perturbation	0.76
PubMedID	0.71
microRNA	0.69
histone modification site profile	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.37   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.37   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0