| Tbio | Stabilin-1 |
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]
This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis, Juvenile | 126 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Bipolar Disorder | 666 |
| Juvenile arthritis | 126 |
| Manic | 14 |
| Manic mood | 6 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.0e-06 |
| adrenocortical carcinoma | 1428 | 4.3e-06 |
| tuberculosis | 2010 | 6.5e-05 |
| pituitary cancer | 1972 | 1.1e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.1e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.6e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 8.6e-04 |
| ductal carcinoma in situ | 1745 | 1.9e-03 |
| subependymal giant cell astrocytoma | 2287 | 2.5e-03 |
| glioblastoma | 5792 | 2.8e-03 |
| ependymoma | 4679 | 4.0e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 7.4e-03 |
| astrocytic glioma | 2597 | 8.1e-03 |
| invasive ductal carcinoma | 2951 | 8.7e-03 |
| group 3 medulloblastoma | 4104 | 1.1e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 2.7e-02 |
| interstitial cystitis | 2312 | 3.5e-02 |
| osteosarcoma | 7950 | 4.0e-02 |
| spina bifida | 1074 | 4.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bacillary angiomatosis | 6 | 3.362 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.980 | 4.3e-06 |
| astrocytic glioma | 1.300 | 8.1e-03 |
| ductal carcinoma in situ | -1.300 | 1.9e-03 |
| ependymoma | 1.600 | 4.0e-03 |
| glioblastoma | 1.800 | 2.8e-03 |
| group 3 medulloblastoma | -1.100 | 1.1e-02 |
| interstitial cystitis | 1.200 | 3.5e-02 |
| intraductal papillary-mucinous adenoma (... | -1.200 | 2.1e-04 |
| intraductal papillary-mucinous carcinoma... | -1.200 | 5.6e-04 |
| intraductal papillary-mucinous neoplasm ... | -1.400 | 8.6e-04 |
| invasive ductal carcinoma | 1.129 | 8.7e-03 |
| mucosa-associated lymphoid tissue lympho... | 1.129 | 2.7e-02 |
| osteosarcoma | -1.118 | 4.0e-02 |
| ovarian cancer | 2.200 | 1.0e-06 |
| pancreatic ductal adenocarcinoma liver m... | -1.225 | 7.4e-03 |
| pituitary cancer | -1.100 | 1.1e-04 |
| spina bifida | 1.353 | 4.2e-02 |
| subependymal giant cell astrocytoma | 3.076 | 2.5e-03 |
| tuberculosis | 1.100 | 6.5e-05 |
MAGPRGLLPLCLLAFCLAGFSFVRGQVLFKGCDVKTTFVTHVPCTSCAAIKKQTCPSGWLRELPDQITQD 1 - 70 CRYEVQLGGSMVSMSGCRRKCRKQVVQKACCPGYWGSRCHECPGGAETPCNGHGTCLDGMDRNGTCVCQE 71 - 140 NFRGSACQECQDPNRFGPDCQSVCSCVHGVCNHGPRGDGSCLCFAGYTGPHCDQELPVCQELRCPQNTQC 141 - 210 SAEAPSCRCLPGYTQQGSECRAPNPCWPSPCSLLAQCSVSPKGQAQCHCPENYHGDGMVCLPKDPCTDNL 211 - 280 GGCPSNSTLCVYQKPGQAFCTCRPGLVSINSNASAGCFAFCSPFSCDRSATCQVTADGKTSCVCRESEVG 281 - 350 DGRACYGHLLHEVQKATQTGRVFLQLRVAVAMMDQGCREILTTAGPFTVLVPSVSSFSSRTMNASLAQQL 351 - 420 CRQHIIAGQHILEDTRTQQTRRWWTLAGQEITVTFNQFTKYSYKYKDQPQQTFNIYKANNIAANGVFHVV 421 - 490 TGLRWQAPSGTPGDPKRTIGQILASTEAFSRFETILENCGLPSILDGPGPFTVFAPSNEAVDSLRDGRLI 491 - 560 YLFTAGLSKLQELVRYHIYNHGQLTVEKLISKGRILTMANQVLAVNISEEGRILLGPEGVPLQRVDVMAA 561 - 630 NGVIHMLDGILLPPTILPILPKHCSEEQHKIVAGSCVDCQALNTSTCPPNSVKLDIFPKECVYIHDPTGL 631 - 700 NVLKKGCASYCNQTIMEQGCCKGFFGPDCTQCPGGFSNPCYGKGNCSDGIQGNGACLCFPDYKGIACHIC 701 - 770 SNPNKHGEQCQEDCGCVHGLCDNRPGSGGVCQQGTCAPGFSGRFCNESMGDCGPTGLAQHCHLHARCVSQ 771 - 840 EGVARCRCLDGFEGDGFSCTPSNPCSHPDRGGCSENAECVPGSLGTHHCTCHKGWSGDGRVCVAIDECEL 841 - 910 DMRGGCHTDALCSYVGPGQSRCTCKLGFAGDGYQCSPIDPCRAGNGGCHGLATCRAVGGGQRVCTCPPGF 911 - 980 GGDGFSCYGDIFRELEANAHFSIFYQWLKSAGITLPADRRVTALVPSEAAVRQLSPEDRAFWLQPRTLPN 981 - 1050 LVRAHFLQGALFEEELARLGGQEVATLNPTTRWEIRNISGRVWVQNASVDVADLLATNGVLHILSQVLLP 1051 - 1120 PRGDVPGGQGLLQQLDLVPAFSLFRELLQHHGLVPQIEAATAYTIFVPTNRSLEAQGNSSHLDADTVRHH 1121 - 1190 VVLGEALSMETLRKGGHRNSLLGPAHWIVFYNHSGQPEVNHVPLEGPMLEAPGRSLIGLSGVLTVGSSRC 1191 - 1260 LHSHAEALREKCVNCTRRFRCTQGFQLQDTPRKSCVYRSGFSFSRGCSYTCAKKIQVPDCCPGFFGTLCE 1261 - 1330 PCPGGLGGVCSGHGQCQDRFLGSGECHCHEGFHGTACEVCELGRYGPNCTGVCDCAHGLCQEGLQGDGSC 1331 - 1400 VCNVGWQGLRCDQKITSPQCPRKCDPNANCVQDSAGASTCACAAGYSGNGIFCSEVDPCAHGHGGCSPHA 1401 - 1470 NCTKVAPGQRTCTCQDGYMGDGELCQEINSCLIHHGGCHIHAECIPTGPQQVSCSCREGYSGDGIRTCEL 1471 - 1540 LDPCSKNNGGCSPYATCKSTGDGQRTCTCDTAHTVGDGLTCRARVGLELLRDKHASFFSLRLLEYKELKG 1541 - 1610 DGPFTIFVPHADLMSNLSQDELARIRAHRQLVFRYHVVGCRRLRSEDLLEQGYATALSGHPLRFSEREGS 1611 - 1680 IYLNDFARVVSSDHEAVNGILHFIDRVLLPPEALHWEPDDAPIPRRNVTAAAQGFGYKIFSGLLKVAGLL 1681 - 1750 PLLREASHRPFTMLWPTDAAFRALPPDRQAWLYHEDHRDKLAAILRGHMIRNVEALASDLPNLGPLRTMH 1751 - 1820 GTPISFSCSRTRAGELMVGEDDARIVQRHLPFEGGLAYGIDQLLEPPGLGARCDHFETRPLRLNTCSICG 1821 - 1890 LEPPCPEGSQEQGSPEACWRFYPKFWTSPPLHSLGLRSVWVHPSLWGRPQGLGRGCHRNCVTTTWKPSCC 1891 - 1960 PGHYGSECQACPGGPSSPCSDRGVCMDGMSGSGQCLCRSGFAGTACELCAPGAFGPHCQACRCTVHGRCD 1961 - 2030 EGLGGSGSCFCDEGWTGPRCEVQLELQPVCTPPCAPEAVCRAGNSCECSLGYEGDGRVCTVADLCQDGHG 2031 - 2100 GCSEHANCSQVGTMVTCTCLPDYEGDGWSCRARNPCTDGHRGGCSEHANCLSTGLNTRRCECHAGYVGDG 2101 - 2170 LQCLEESEPPVDRCLGQPPPCHSDAMCTDLHFQEKRAGVFHLQATSGPYGLNFSEAEAACEAQGAVLASF 2171 - 2240 PQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGIVSLGARKNLSERWDAYCFRVQDVACRCR 2241 - 2310 NGFVGDGISTCNGKLLDVLAATANFSTFYGMLLGYANATQRGLDFLDFLDDELTYKTLFVPVNEGFVDNM 2311 - 2380 TLSGPDLELHASNATLLSANASQGKLLPAHSGLSLIISDAGPDNSSWAPVAPGTVVVSRIIVWDIMAFNG 2381 - 2450 IIHALASPLLAPPQPQAVLAPEAPPVAAGVGAVLAAGALLGLVAGALYLRARGKPMGFGFSAFQAEDDAD 2451 - 2520 DDFSPWQEGTNPTLVSVPNPVFGSDTFCEPFDDSLLEEDFPDTQRILTVK 2521 - 2570 //
