Tbio ST8SIA6 Alpha-2,8-sialyltransferase 8F

Protein Summary

Description

Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)-Gal sequence at the non-reducing end of their carbohydrate groups (By similarity). This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• P61647
• B0YJ97
• B9EH72
• Q5VZH4

Gene Name

• ST8SIA6

Ensembl ID

• ENST00000377602
• ENSP00000366827
• ENSG00000148488

Symbol

• SIAT8F
• SIA8F
• SIAT8F
• SIAT8-F
• ST8SiaVI
• ST8SIA-VI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.85
histone modification site profile	0.75
tissue sample	0.69
cellular component	0.67
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.49   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.49   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0