ST3GAL3
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Protein Summary
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with a form of autosomal recessive nonsymdromic cognitive disability as well as infantile epileptic encephalopathy. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
- ENST00000262915
- ENSP00000262915
- ENSG00000126091
- ENST00000330208
- ENSP00000333494
- ENST00000335430
- ENSP00000335633
- ENST00000347631
- ENSP00000317192
- ENST00000351035
- ENSP00000316999
- ENST00000353126
- ENSP00000330463
- ENST00000361392
- ENSP00000355341
- ENST00000361400
- ENSP00000354748
- ENST00000361812
- ENSP00000355201
- ENST00000372362
- ENSP00000361437
- ENST00000372365
- ENSP00000361440
- ENST00000372366
- ENSP00000361441
- ENST00000372367
- ENSP00000361442
- ENST00000372369
- ENSP00000361444
- ENST00000372372
- ENSP00000361447
- ENST00000372374
- ENSP00000361449
- ENST00000469715
- ENSP00000431700
- ENST00000489897
- ENSP00000437206
- ENST00000490541
- ENSP00000435018
- ENST00000528371
- ENSP00000434876
- ENST00000530581
- ENSP00000437293
- ENST00000531451
- ENSP00000435603
- ENST00000531816
- ENSP00000434378
- ENST00000531993
- ENSP00000432682
- ENST00000533212
- ENSP00000435621
- ENST00000533997
- ENSP00000432071
- ENST00000545417
- ENSP00000439634
- ENST00000642504
- ENSP00000494857
- ENST00000642934
- ENSP00000494146
- ENST00000642949
- ENSP00000495709
- ENST00000644195
- ENSP00000494201
- ENST00000645142
- ENSP00000496550
- ENST00000645165
- ENSP00000493660
- ENST00000645640
- ENSP00000494852
- ENST00000646971
- ENSP00000495887
- SIAT6
- ST3N
- MRT12
- SIAT6
- EIEE15
- ST3GALII
- ST3GalIII
- ST3Gal III
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.98 | ||
histone modification site profile | 0.9 | ||
transcription factor | 0.83 | ||
transcription factor binding site profile | 0.69 | ||
pathway | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.16 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 152 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.16 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 152 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0