Tbio SSBP2 Single-stranded DNA-binding protein 2

Protein Summary

Description

This gene encodes a subunit of a protein complex that interacts with single-stranded DNA and is involved in the DNA damage response and maintenance of genome stability. The encoded protein may also play a role in telomere repair. A variant of this gene may be associated with survival in human glioblastoma patients. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• P81877
• B2R5W1
• B7Z1J2
• B7Z2L9
• B7Z665
• D6RH18
• E9PB74
• E9PDA8
• Q8N2Q2
• Q9BWW6
• Q9Y4T7

Gene Name

• SSBP2

Ensembl ID

• ENST00000320672
• ENSP00000322977
• ENSG00000145687
• ENST00000505980
• ENSP00000423969
• ENST00000509053
• ENSP00000422961
• ENST00000514493
• ENSP00000426183
• ENST00000515395
• ENSP00000424657

Symbol

• SSDP2
• HSPC116
• SOSS-B2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
transcription factor binding site profile	0.92
PubMedID	0.91
disease perturbation	0.87
kinase perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0