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  5. 3-oxo-5-alpha-steroid 4-dehydrogenase 1

Tclin 3-oxo-5-alpha-steroid 4-dehydrogenase 1

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]

 Comments

Property Summary

Ligand Count 327
NCBI Gene PubMed Count 92
PubMed Score 90.66
PubTator Score 1570.70

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Prostate cancer 175 4.092 2.0

Expression

  Differential Expression (25)

Disease log2 FC p
adrenocortical carcinoma 1.763 2.8e-04
adult high grade glioma -3.100 6.0e-05
astrocytic glioma -3.300 1.6e-03
Astrocytoma, Pilocytic -3.800 3.4e-11
atypical teratoid / rhabdoid tumor -2.800 3.9e-06
colon cancer 1.300 3.5e-02
ductal carcinoma in situ 2.300 7.8e-04
ependymoma -3.500 3.2e-03
esophageal adenocarcinoma -1.400 4.0e-02
glioblastoma -2.800 1.6e-08
intraductal papillary-mucinous adenoma (... 1.400 9.7e-03
intraductal papillary-mucinous carcinoma... 1.200 1.8e-02
intraductal papillary-mucinous neoplasm ... 2.500 2.9e-03
invasive ductal carcinoma 2.800 7.0e-03
lung adenocarcinoma 1.896 3.9e-07
lung cancer 1.200 1.8e-02
lung carcinoma 1.400 2.0e-24
medulloblastoma, large-cell -1.200 4.5e-03
non-small cell lung cancer 2.731 8.7e-25
oligodendroglioma -3.000 4.2e-03
ovarian cancer 1.100 3.1e-02
pancreatic cancer 1.100 2.5e-04
Parkinson's disease -1.200 4.6e-02
Pick disease -1.500 1.9e-03
tuberculosis 1.700 3.0e-07

Synonym

Accession P18405 B2R7Q1 Q9UHY4 Q9UP36 Q9UP37
Symbols S5AR 1

Gene

SRD5A1

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (11)

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 GO Function (5)

 GO Component (7)

 GO Process (33)

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 Compartment GO Term (23)

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 MGI Phenotype (2)

 GWAS Trait (1)

 HCA RNA Cell Line (56)

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Pathway (11)

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Protein-protein Interaction (1)

ACTBL2  

Drug (2)

Structure of dutasteride

dutasteride
pIC50 8.49

Structure of finasteride

finasteride
pIC50 7.58

Ligand (324)

Structure of CHEMBL183692

CHEMBL183692
pIC50 6.00

Structure of CHEMBL333684

CHEMBL333684
pIC50 6.00

Structure of CHEMBL78161

CHEMBL78161
pKi 6.00

Structure of CHEMBL16248

CHEMBL16248
pIC50 6.00

Structure of CHEMBL278049

CHEMBL278049
pIC50 6.00

Structure of CHEMBL77650

CHEMBL77650
pIC50 6.00

Structure of CHEMBL283564

CHEMBL283564
pIC50 6.01

Structure of CHEMBL116370

CHEMBL116370
pIC50 6.02

Structure of CHEMBL118283

CHEMBL118283
pIC50 6.03

Structure of CHEMBL97266

CHEMBL97266
pKi 6.04

Structure of CHEMBL136097

CHEMBL136097
pIC50 6.05

Structure of CHEMBL137040

CHEMBL137040
pIC50 6.05

Structure of CHEMBL248682

CHEMBL248682
pIC50 6.08

Structure of CHEMBL77169

CHEMBL77169
pIC50 6.09

Structure of CHEMBL76192

CHEMBL76192
pKi 6.09

Structure of CHEMBL76648

CHEMBL76648
pKi 6.13

Structure of CHEMBL119722

CHEMBL119722
pIC50 6.14

Structure of CHEMBL136863

CHEMBL136863
pKi 6.14

Structure of CHEMBL182399

CHEMBL182399
pIC50 6.15

Structure of CHEMBL24464

CHEMBL24464
pIC50 6.15

Gene RIF (75)

AA Sequence 

MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQ      1 - 70
YASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAV     71 - 140
YADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYA    141 - 210
LASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF                         211 - 259
//

Text Mined References (94)

PMID Year Title