Tclin | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]
Comments
Property Summary
Ligand Count | 327 |
NCBI Gene PubMed Count | 92 |
PubMed Score | 90.66 |
PubTator Score | 1570.70 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Endometriosis | 540 | 0.0 | 0.0 |
Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
Polycystic ovary syndrome | 360 | 0.0 | 0.0 |
Prostatic Neoplasms | 495 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Alcoholic Intoxication, Chronic | 289 |
Bipolar Disorder | 666 |
Depressive disorder | 409 |
Manic | 14 |
Manic mood | 6 |
Mental Depression | 333 |
Disease | Target Count |
---|---|
Benign prostatic hyperplasia | 7 |
Male Patterned Baldness | 2 |
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2890 | 8.7e-25 |
lung carcinoma | 2843 | 2.0e-24 |
Astrocytoma, Pilocytic | 3081 | 3.4e-11 |
glioblastoma | 5792 | 1.6e-08 |
tuberculosis | 2010 | 3.0e-07 |
lung adenocarcinoma | 2716 | 3.9e-07 |
atypical teratoid / rhabdoid tumor | 5112 | 3.9e-06 |
adult high grade glioma | 3801 | 6.0e-05 |
pancreatic cancer | 2398 | 2.5e-04 |
adrenocortical carcinoma | 1428 | 2.8e-04 |
ductal carcinoma in situ | 1745 | 7.8e-04 |
astrocytic glioma | 2597 | 1.6e-03 |
Pick disease | 1894 | 1.9e-03 |
intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.9e-03 |
ependymoma | 4679 | 3.2e-03 |
oligodendroglioma | 2850 | 4.2e-03 |
medulloblastoma, large-cell | 6241 | 4.5e-03 |
invasive ductal carcinoma | 2951 | 7.0e-03 |
intraductal papillary-mucinous adenoma (IPMA) | 2955 | 9.7e-03 |
intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.8e-02 |
lung cancer | 4740 | 1.8e-02 |
ovarian cancer | 8520 | 3.1e-02 |
colon cancer | 1478 | 3.5e-02 |
esophageal adenocarcinoma | 737 | 4.0e-02 |
Parkinson's disease | 392 | 4.6e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Prostate cancer | 175 | 4.092 | 2.0 |
Disease | log2 FC | p |
---|---|---|
adrenocortical carcinoma | 1.763 | 2.8e-04 |
adult high grade glioma | -3.100 | 6.0e-05 |
astrocytic glioma | -3.300 | 1.6e-03 |
Astrocytoma, Pilocytic | -3.800 | 3.4e-11 |
atypical teratoid / rhabdoid tumor | -2.800 | 3.9e-06 |
colon cancer | 1.300 | 3.5e-02 |
ductal carcinoma in situ | 2.300 | 7.8e-04 |
ependymoma | -3.500 | 3.2e-03 |
esophageal adenocarcinoma | -1.400 | 4.0e-02 |
glioblastoma | -2.800 | 1.6e-08 |
intraductal papillary-mucinous adenoma (... | 1.400 | 9.7e-03 |
intraductal papillary-mucinous carcinoma... | 1.200 | 1.8e-02 |
intraductal papillary-mucinous neoplasm ... | 2.500 | 2.9e-03 |
invasive ductal carcinoma | 2.800 | 7.0e-03 |
lung adenocarcinoma | 1.896 | 3.9e-07 |
lung cancer | 1.200 | 1.8e-02 |
lung carcinoma | 1.400 | 2.0e-24 |
medulloblastoma, large-cell | -1.200 | 4.5e-03 |
non-small cell lung cancer | 2.731 | 8.7e-25 |
oligodendroglioma | -3.000 | 4.2e-03 |
ovarian cancer | 1.100 | 3.1e-02 |
pancreatic cancer | 1.100 | 2.5e-04 |
Parkinson's disease | -1.200 | 4.6e-02 |
Pick disease | -1.500 | 1.9e-03 |
tuberculosis | 1.700 | 3.0e-07 |
Species | Source | Disease |
---|---|---|
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
finasteride
pIC50 7.58
CHEMBL183692
pIC50 6.00
CHEMBL333684
pIC50 6.00
CHEMBL78161
pKi 6.00
CHEMBL16248
pIC50 6.00
CHEMBL278049
pIC50 6.00
CHEMBL77650
pIC50 6.00
CHEMBL283564
pIC50 6.01
CHEMBL116370
pIC50 6.02
CHEMBL118283
pIC50 6.03
CHEMBL97266
pKi 6.04
CHEMBL136097
pIC50 6.05
CHEMBL137040
pIC50 6.05
CHEMBL248682
pIC50 6.08
CHEMBL77169
pIC50 6.09
CHEMBL76192
pKi 6.09
CHEMBL76648
pKi 6.13
CHEMBL119722
pIC50 6.14
CHEMBL136863
pKi 6.14
CHEMBL182399
pIC50 6.15
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQELPSLALPLYQ 1 - 70 YASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAV 71 - 140 YADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGDTGYKIPRGGLFEYVTAANYFGEIMEWCGYA 141 - 210 LASWSVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF 211 - 259 //