| Tbio | Sulfide:quinone oxidoreductase, mitochondrial |
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).
The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]
The protein encoded by this gene may function in mitochondria to catalyze the conversion of sulfide to persulfides, thereby decreasing toxic concencrations of sulfide. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 2.3e-09 |
| Astrocytoma, Pilocytic | 3081 | 1.5e-08 |
| pituitary cancer | 1972 | 2.0e-06 |
| medulloblastoma, large-cell | 6241 | 3.5e-05 |
| ovarian cancer | 8520 | 4.2e-05 |
| group 4 medulloblastoma | 1855 | 6.5e-05 |
| glioblastoma | 5792 | 1.6e-04 |
| psoriasis | 6694 | 1.9e-04 |
| lung cancer | 4740 | 3.1e-04 |
| Multiple myeloma | 1332 | 8.4e-04 |
| osteosarcoma | 7950 | 1.5e-03 |
| adrenocortical carcinoma | 1428 | 4.9e-03 |
| pediatric high grade glioma | 1064 | 9.0e-03 |
| colon cancer | 1478 | 1.1e-02 |
| subependymal giant cell astrocytoma | 2287 | 3.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired metabolic disease | 336 | 0.0 | 1.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Ethylmalonic encephalopathy | 12 | 4.437 | 2.2 |
| Varicose veins | 20 | 3.375 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | -1.383 | 4.9e-03 |
| Astrocytoma, Pilocytic | 1.700 | 1.5e-08 |
| colon cancer | -3.100 | 1.1e-02 |
| glioblastoma | 2.300 | 1.6e-04 |
| group 4 medulloblastoma | -1.100 | 6.5e-05 |
| lung cancer | -2.500 | 3.1e-04 |
| malignant mesothelioma | -4.800 | 2.3e-09 |
| medulloblastoma, large-cell | -1.600 | 3.5e-05 |
| Multiple myeloma | 1.365 | 8.4e-04 |
| osteosarcoma | -1.904 | 1.5e-03 |
| ovarian cancer | -2.400 | 4.2e-05 |
| pediatric high grade glioma | 1.100 | 9.0e-03 |
| pituitary cancer | -2.300 | 2.0e-06 |
| psoriasis | 1.200 | 1.9e-04 |
| subependymal giant cell astrocytoma | 1.955 | 3.1e-02 |
MVPLVAVVSGPRAQLFACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKRKVGAEN 1 - 70 VAIVEPSERHFYQPIWTLVGAGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRY 71 - 140 LIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKTWKALQDFKEGNAIFTFPNTPVKCAGAPQKIMY 141 - 210 LSEAYFRKTGKRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRADKQEAVFENLDK 211 - 280 PGETQVISYEMLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVA 281 - 350 AQSGILDRTISVIMKNQTPTKKYDGYTSCPLVTGYNRVILAEFDYKAEPLETFPFDQSKERLSMYLMKAD 351 - 420 LMPFLYWNMMLRGYWGGPAFLRKLFHLGMS 421 - 450 //
