Property Summary

NCBI Gene PubMed Count 23
PubMed Score 5.45
PubTator Score 5.90

Knowledge Summary


No data available



Accession Q96BD6 A2A275 Q59FA1 Q5TIH9 Q9BRY9 Q9H6C5 SSB-1
Symbols SSB1



2JK9   3F2O  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Protein-protein Interaction (9)

Gene RIF (5)

26032413 SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.
24786206 Findings define a novel pathway that contributes to breast cancer recurrence and provide evidence implicating SPSB proteins in cancer.
23333304 HIV-1 Vif downregulates the expression of splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1) in Vif-expression T cells
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19683501 SSB1/2 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.

AA Sequence


Text Mined References (25)

PMID Year Title
26032413 2015 SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-? Signaling Pathway Targeting the Type II Receptor.
25203322 2014 PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.
24786206 2014 SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.
23455924 2013 A Y2H-seq approach defines the human protein methyltransferase interactome.
23064961 2013 GWAS of dental caries patterns in the permanent dentition.
22658931 2012 A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.
22491018 2013 Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
20561531 2010 Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19683501 2009 SOSS complexes participate in the maintenance of genomic stability.
19028597 2009 Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
17189197 2006 Structural basis for protein recognition by B30.2/SPRY domains.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16498413 2006 Structural and functional insights into the B30.2/SPRY domain.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15713673 2005 The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.
15601820 2004 VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12076535 2002 The SOCS box: a tale of destruction and degradation.
9110174 1997 Large-scale concatenation cDNA sequencing.
8619474 1996 A "double adaptor" method for improved shotgun library construction.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.