Property Summary

NCBI Gene PubMed Count 12
PubMed Score 300.65
PubTator Score 25.77

Knowledge Summary


No data available

Gene RIF (8)

24390475 Shadoo is degraded in Scrapie-infected rodents and cultured cells mediated by proteasome degradation after modification by ubiquitination.
21257747 a conserved physiological activity between PrP(C) and Sho to protect cells from stress-induced toxicity and suggests that Sho and PrP(C) might act on similar signaling pathways.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
18805828 Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease
18805828 Observational study of gene-disease association. (HuGE Navigator)
18778261 A novel solid phase technology for high- throughput synthesis of the SPRN gene is reported.

AA Sequence

GALGALGLLRP                                                               141 - 151

Text Mined References (14)

PMID Year Title
24390475 2014 Disruption of glycosylation enhances ubiquitin-mediated proteasomal degradation of Shadoo in Scrapie-infected rodents and cultured cells.
21257747 2011 Conserved stress-protective activity between prion protein and Shadoo.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
18805828 2008 Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.
18778261 2008 A novel solid phase technology for high-throughput gene synthesis.
17199895 2007 Comparative genomic analysis of prion genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342797 2004 Evolution of vertebrate genes related to prion and Shadoo proteins--clues from comparative genomic analysis.
14527721 2003 Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9776767 1998 A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.