Tchem SPR Sepiapterin reductase

Protein Summary

Description

Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin. This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P35270
• A8K741
• D6W5H2
• Q53GI9
• Q9UBB1
• SPR

Gene Name

• SPR

Ensembl ID

• ENST00000234454
• ENSP00000234454
• ENSG00000116096

Symbol

• SDR38C1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.76
kinase perturbation	0.76
interacting protein	0.71
transcription factor binding site profile	0.71
cell type or tissue	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 314   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 963

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0