Tchem SPPL2A Signal peptide peptidase-like 2A

Protein Summary

Description

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q8TCT8
• B2RDS0
• Q8TAW1
• Q96SZ8
• SPP-like 2A

Gene Name

• SPPL2A

Ensembl ID

• ENST00000261854
• ENSP00000261854
• ENSG00000138600

Symbol

• IMP3
• PSL2
• IMP3
• PSL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
transcription factor binding site profile	0.82
histone modification site profile	0.79
small molecule perturbation	0.75
cellular component	0.73

Protein Classes

PANTHER Classes

Protein / ... / Aspartic Protease / Signal Peptide Peptidase-like 2a

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Signal Peptide Peptidase-like 2a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.61   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.61   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0