Tbio SPO11 Meiotic recombination protein SPO11

Protein Summary

Description

Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2. Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y5K1
• Q5TCI1
• Q8N4V0
• Q9NQM7
• Q9NQM8

Gene Name

• SPO11

Ensembl ID

• ENST00000345868
• ENSP00000316034
• ENSG00000054796
• ENST00000371263
• ENSP00000360310

Symbol

• CT35
• TOPVIA
• SPATA43

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.84
protein domain	0.73
cellular component	0.64
biological process	0.59
gene perturbation	0.58

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Meiotic Recombination Protein Spo11

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Meiotic Recombination Protein Spo11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 438.51   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 438.51   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0