| Tbio | Serine protease inhibitor Kazal-type 9 |
Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5.
The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015]
The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Pompholyx | 4 | 4.961 | 2.5 |
| Netherton syndrome | 15 | 4.497 | 2.2 |
| Peeling skin syndrome | 17 | 4.283 | 2.1 |
| Epidermolysis bullosa simplex | 9 | 3.369 | 1.7 |
| Actinic keratosis | 21 | 3.228 | 1.6 |
| Dermatitis | 157 | 3.028 | 1.5 |
